A5013325937- French Urban and Social Studies
- Transboundary Water Resource Management
- Water Governance and Infrastructure
- International Environmental Law and Policies
- ICT Impact and Policies
- Epigenetics and DNA Methylation
- Hydrology and Watershed Management Studies
- Cultural Insights and Digital Impacts
- Flood Risk Assessment and Management
- Glioma Diagnosis and Treatment
- Water resources management and optimization
- Digital Transformation in Industry
- Merger and Competition Analysis
- Coastal and Marine Management
- European Union Policy and Governance
- Cross-Border Cooperation and Integration
- Tuberous Sclerosis Complex Research
- School Health and Nursing Education
- Dermatological and Skeletal Disorders
- International Labor and Employment Law
- African studies and sociopolitical issues
- Open Source Software Innovations
- Economic and Technological Innovation
- Philosophical and Theoretical Analysis
- Healthcare Systems and Practices
King's College London
2025
King's College Hospital
2025
Foundation for Liver Research
2025
Centre hospitalier régional d'Orléans
2023
Gestion de l'Eau, Acteurs, Usages
2010-2021
AgroParisTech
2009-2021
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2017-2021
Institut de Recherche pour le Développement
2017-2021
Institut Agro Montpellier
2017-2021
Université de Montpellier
2021
V-domain Ig-containing suppressor of T cell activation (VISTA) is a unique immune checkpoint protein, which was reported to display both receptor and ligand activities. However, the mechanisms regulation VISTA activity functions by factors tumour microenvironment (TME) remain unclear understanding these processes required in order develop successful personalised cancer immunotherapeutic strategies approaches. Here we report for very first time that interacts with another protein galectin-9...
Purpose The purpose of this paper is to address the difficulties faced by manufacturing enterprises providing a project portfolio management approach supporting selection and prioritization various Industry 4.0 projects where business process analysis used ensure strategic alignment value portfolio. Design/methodology/approach design research methodology, mixed applied was develop test proposed approach. Findings Despite growing interest scientific industrial communities in I4.0, it seems...
Abstract Introduction: T cell engagers (TCEs) are a promising class of targeted therapies with recent clinical successes in solid tumors. A unique advantage HLA-presented targets is that they can be derived from any part the human genome providing an opportunity to build next generation TCEs against novel targets. We here present our discovery and development half-life extended TCE tumor-target towards candidate selection. Our proprietary drug format based on solubilized TCR, engineered as...
Abstract Introduction: T cell engagers (TCEs) are a class of targeted therapies with demonstrated clinical potential in solid tumors. A main challenge currently facing TCEs is the availability clean cancer targets wide therapeutic window. Intracellular presented to cells by HLA complexes strongly linked disease mechanisms and therefore very attractive, but drugging HLA-presented has been challenged our ability map specificity repertoires. We here present T-Cα platform, which represents...
This paper provides a synthetic presentation of French water governance and its evolution since the 1960s. Through this experience, it discusses Organisation for Economic Co-operation Development (OECD) cycle showing disputes as main drivers change. France has been pioneer in introducing river basin management some 50 years ago. It is also noted services by local authorities, leaving significant role to private public companies. But not frozen 1960s continues change radically within...
Abstract Introduction ALK and ROS1 rearrangements are molecular targets of several tyrosine kinase inhibitors. RNA‐sequencing approaches regarded as the new standard for fusion gene detection, representing an alternative to immunohistochemistry (IHC) fluorescence in situ hybridization (FISH) techniques. Patients Methods We aimed compare two recent amplicon‐based techniques: FusionPlex ® Alk Ret Ros1 v2 Kit (Archer ) with FHS‐003Z‐12—Human Lung Cancer Panel (Qiagen assessed accuracy data...
Renaissance studies continue to grow in post-colonial Africa. This study explores the Ndau culture a bid assess its vitality and relevance contemporary society’s water technology Zimbabwe. The thesis of posits that people have indigenous knowledge systems (IKS) can be tapped implementation resource management. Some beliefs practices on resources used as environmental management tools order do justice climate change. These, if blended with western technologies, effective intervention...
Abstract Background Epigenetic inactivation of O6‐methylguanine‐methyltransferase ( MGMT ) gene by methylation its promoter is predictive Temozolomid (TMZ) response in glioblastoma (GBM). located on chromosome 10q26 and the loss 10q observed 70% GBMs. In this study, we assessed hypothesis that dual , hypermethylation long arm 10 (10q), may confer greater sensitivity to TMZ. Methods A total 149 tumor samples from patients diagnosed with GBM based WHO 2016 classification were included...
Abordant les modalités de gestion l’eau en France dans la seconde moitié du XXème siècle et l’illustrant à partir SAGE rivière Drôme, cet article analyse transition d’une forme gouvernement centralisé vers une gouvernance locale. Il précise situation caractérise recomposition l’action publique résultant au vu littérature. identifie différents niveaux d’action leurs interactions le cas Drôme. questionne ensuite qui découle sous l’angle l’intégration l’environnement développement économique.
En se focalisant sur les politiques de gestion l’eau, cet article aborde la question des usages sociaux frontière, leur complexité et ambiguïté ainsi que l’incidence ces derniers gouvernance du territoire transfrontalier. L’exemple plaine cerdane, à frontière entre France l’Espagne, permet distinguer plusieurs types d’usage frontière: un usage social pour légitimer le maintien pratiques politique institutionnel jouant niveaux d’action publique. Malgré volontarisme certains acteurs, l’eau...