Capsaicin (8-methyl-N-vanillyl-6-nonemide) is the major pungent principle found in hot peppers of plant genus Capsicum. The present work was undertaken to investigate antioxidative property capsaicin on markers oxidative stress; membrane lipid peroxidation (formation malondialdehyde) and carbonyl groups human erythrocytes. effect has been compared with l-ascorbic acid. Subjecting erythrocytes stress by incubating them t-BHP caused a significant increase MDA level protein group content above...

Abstract : The correlation between antioxidant capacity and oxidative damage during aging has been reported in several tissues different species; however, data on changes of stress markers plasma erythrocytes healthy populations are few sometimes contradictory. Since the is related to dietary intake antioxidants, it important study populations. In present we report age‐dependent alteration erythrocyte malondialdehyde (MDA), intracellular‐reduced glutathione (GSH), membrane sulphydryl (SH)...

Metformin, a biguanide, is widely used antidiabetic drug, which inhibits gluconeogenesis and to treat hyperglycemia in type 2 diabetes. Through activation of AMPK (AMP-activated protein kinase) pathway, metformin also mimics caloric restriction health benefits. Aging causes substantial molecular morphological changes brain, the brain cells being more susceptible toward oxidative stress mediated damages due presence high lipid content higher oxygen consumption. Wistar rats (naturally aged...

Eukaryotic cells display a plasma membrane redox system (PMRS) that transfers electrons from intracellular substrates to extracellular electron acceptors. The physiologic importance of PMRS is still not fully understood. authors have carried out studies determine the activity in human erythrocytes as function age and correlate with total antioxidant capacity an effort understand role aging. study was on 80 normal healthy subjects both genders between ages 18 85 years. erythrocyte estimated...

SUMMARY 1. Oxidative stress is recognized as a major contributing factor for the development of late complications diabetes. 2. Tea contains polyphenolic compounds (catechins), which have many important biological properties, including strong anti‐oxidant activity. 3. The present study was undertaken to evaluate effect tea catechins (epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin (ECG) and (EC)) on markers oxidative (malondialdehyde (MDA), reduced glutathione (GSH)...

Antioxidant effect of tea catechins has been shown in many epidemiological studies. In the present study we report protective mechanism (EGCG, ECG, EGC, EC) on various oxidative stress parameters, which are elevated during aging humans. We hereby vitro erythrocyte malondialdehyde (MDA), reduced glutathione (GSH), and membrane sulphydryl (-SH) group Results show an age-dependent increase MDA level a decrease GSH membrane-SH concentration. that significant protection to against induced by...

Polyphenols are among a wide variety of active photochemicals present in the human diet. Basic researches and epidemiological studies have shown inverse association between risk cancer, CVDs, diabetes, several age related chronic diseases intake diet rich polyphenols. Recent opened possibility dietary polyphenols to be considered as phytomedicine. Most on bioactivity been conducted animal models vitro systems, direct humans few results inconclusive. The bioavailability biotransformation...

Resveratrol is a natural polyphenolic compound found largely in the skin of red grapes. Growing evidence suggests that resveratrol may play an important role prevention many human diseases. Many biological actions this polyphenol have been attributed to its antioxidant properties. The present study was undertaken evaluate effect on intracellular reduced glutathione (GSH) and membrane sulphydryl groups erythrocytes subjected oxidative stress vitro by incubating with t-BHP (10 microm). aimed...

Oxidative stress plays a vital role in diabetic complications. To suppress the oxidative mediated damage pathophysiology, special focus has been given on composite extract (CE) and making small dose of naturally occurring antidiabetic plants leaf fruits. The aim present study was to evaluate beneficial CE against alloxan- (ALX-) induced diabetes Wistar strain rats. A dose-dependent for (25, 50, 100 mg/kg body weight) carried out find effective compound ALX-induced ALX exposure elevated blood...

Metformin, a biguanide drug commonly used to treat type 2 diabetes, has been noted function as caloric restriction mimetic. Its antidiabetic effect notwithstanding, metformin is currently being considered an antiaging candidate, although the molecular mechanisms have not yet unequivocally established. This study aims examine whether short-term treatment can provide protective effects against oxidative stress in young and old-age rats. Young (age 4 months) old 24 male Wistar rats were treated...