Metformin, a biguanide, is widely used antidiabetic drug, which inhibits gluconeogenesis and to treat hyperglycemia in type 2 diabetes. Through activation of AMPK (AMP-activated protein kinase) pathway, metformin also mimics caloric restriction health benefits. Aging causes substantial molecular morphological changes brain, the brain cells being more susceptible toward oxidative stress mediated damages due presence high lipid content higher oxygen consumption. Wistar rats (naturally aged...

Metformin, a biguanide drug commonly used to treat type 2 diabetes, has been noted function as caloric restriction mimetic. Its antidiabetic effect notwithstanding, metformin is currently being considered an antiaging candidate, although the molecular mechanisms have not yet unequivocally established. This study aims examine whether short-term treatment can provide protective effects against oxidative stress in young and old-age rats. Young (age 4 months) old 24 male Wistar rats were treated...

The antiulcer effect of aqueous extracts the leaves neem tree was investigated in rats exposed to 2-h cold-restraint stress or given ethanol orally for 1 h. Extracts were administered doses 10, 40, 160 mg leaf/kg body weight, either as single- five-dose pretreatment regimens. Neem dose-dependently reduced gastric ulcer severity subjected and also decreased provoked mucosal damage. extract appeared prevent mast cell degranulation increase amount adherent mucus stressed animals. These effects...

An imbalanced cellular redox system promotes the production of reactive oxygen species (ROS) that may lead to oxidative stress-mediated cell death. Erythrocytes are best-studied model antioxidant defense mechanism. The present study was undertaken investigate effect immunosuppressant drug rapamycin, an inducer autophagy, on balance erythrocytes and blood plasma oxidatively challenged rats. Male Wistar rats were with HgCl2 (5 mg/kg body mass (b.m.)). A significant (p < 0.05) induction in ROS...

Brain aging is an intricate and natural phenomenon exclusively characterized by oxidative stress, accumulation of oxidatively damaged macromolecules, alterations in structure function neurons that further increase the risk factor for most neurodegenerative diseases. In addition, age-dependent defective autophagy has also been implicated to favor pathogenesis prevalence neurological Therefore, development strategies delay concomitant disorders remain elusive. Thus, present study was...

During the period 1990-2002 in Himachal Pradesh, India, 103 new patients with cutaneous sporotrichosis were detected. Lymphocutaneous and fixed varieties most common seen 49% 43% respectively. Chronic non-specific inflammation without granuloma formation was 46% skin biopsy specimens, 29% showed acute or chronic tuberculoid 25%. In 32% of cases Sporothrix schenckii growth on Sabouraud glucose agar. A saturated solution potassium iodide used as first-line treatment 93% healing lesions...

N-acetyl-l-cysteine (NAC) is a precursor of cysteine, which known to increase the level glutathione (GSH) in brain. Several neurodegenerative changes linked oxidative stress take place aging This study aimed assess neuroprotective effect NAC supplementation on age-dependent neurodegeneration rat Young (4 months) and old (24 Wistar rats (n = 6 rats/group) were supplemented with (100 mg/kg b.w. orally) for 14 days. Enzymatic nonenzymatic antioxidants such as superoxide dismutase catalase, GSH...

Whey protein concentrate (WPC) is a rich source of sulfur-containing amino acids and consumed as functional food, incorporating wide range nutritional attributes. The purpose this study to evaluate the neuroprotective effect WPC on rat brain during aging. Young (4 months) old (24 male Wistar rats were supplemented with (300 mg/kg body weight) for 28 days. Biomarkers oxidative stress antioxidant capacity in terms ferric reducing potential (FRAP), lipid hydroperoxide (LHP), total thiol (T-SH),...

Acetaminophen or N-acetyl-p-amino-phenol (APAP) is a drug which available over-the-counter for fever and pain. Its overdosing causes oxidative stress subsequent acute liver damage. In the present study, we scrutinized protective effect of metformin co-treatment in APAP induced blood sub-acute toxicity. This pre-clinical study male Wistar Rats (BW: 300 ± 20 g) were orally co-treated with (1 g/kg/day) (300 mg/kg/day) 28-days. Pro- anti-oxidant markers viz reactive oxygen species, protein...

An imbalanced redox status is a hallmark of the aging process. Caloric restriction mimetics (CRMs) are compounds that produce caloric benefits at molecular, cellular, and physiological level, translating into health-promoting effects. Fisetin least explored CRM, its role in modulating oxidative stress during not clearly known. This study investigated antioxidative protective potential fisetin rat model d-galactose (D-gal)-induced accelerated senescence, naturally aged erythrocytes. Young...

Fisetin as a caloric restriction mimetic (CRM) exerts numerous beneficial effects on different aging model systems. The effect of fisetin erythrocyte membrane functions against induced is not very clear.The potential role in the modulation erythrocytes membrane-bound transporters during natural and rats was assessed.Male Wistar were used for D-galactose (D-gal) model. After supplementation with fisetin, activities biomarkers oxidative stress evaluated.Fisetin modulated such calcium-ATPase,...

Erythrocyte membrane is a suitable model to study various metabolic and physiological functions as it undergoes variety of biochemical changes during aging. An age-dependent modulatory effect rapamycin on erythrocyte completely unknown. Therefore, the present was undertaken investigate impaired activities transporters/exchangers, altered levels redox biomarkers, viz. protein carbonyl (PC), lipid hydroperoxides (LHs), total thiol (-SH), sialic acid (SA) intracellular calcium ion [Ca2+]i,...

Erythrocytes are particularly vulnerable toward age-dependent oxidative stress-mediated damage. Caloric restriction mimetics (CRMs) may provide a novel strategy for the maintenance of redox balance as well effective treatment age-associated diseases. Herein, we have investigated beneficial effect cotreatment with CRM-candidate drugs, rapamycin (an immunosuppressant drug and inhibitor mammalian target rapamycin) metformin antidiabetic biguanide activator adenosine monophosphate kinase),...

Background: Vitamin D was considered important for bone and calcium. Historically thought to be calcium metabolism but recent studies have redefined its role. There is some evidence now that low levels of are associated with the risk preeclampsia more needed prove same. This study done determine whether vitamin deficiency an independent factor preeclampsia/eclampsia.Methods: In this prospective case control were estimated in 92 women divided into two groups. Group 1(n = 42) included pregnant...

Circadian disruption due to artificial light affects cellular redox homeostasis and may lead neurodegenerative diseases. The aim of the present study was investigate effect continuous exposure (CLE) dark (CDE) along with melatonin supplementation on neuronal status, mitochondrial complexes, membrane bound transporters, inflammation, autophagy neurodegeneration in chronodisrupted model rat. In white LED bulb 500 lux intensity used. Melatonin (10 mg/kg b.w., orally) supplemented control CLE...