A5017296938- Particle physics theoretical and experimental studies
- Dark Matter and Cosmic Phenomena
- Neutrino Physics Research
- Black Holes and Theoretical Physics
- Quantum Chromodynamics and Particle Interactions
- Cosmology and Gravitation Theories
- Astrophysics and Cosmic Phenomena
- Computational Physics and Python Applications
- Cancer Genomics and Diagnostics
- Particle Detector Development and Performance
- Bacteriophages and microbial interactions
- MRI in cancer diagnosis
- High-Energy Particle Collisions Research
- Lung Cancer Treatments and Mutations
- Neonatal Respiratory Health Research
- Radiation Therapy and Dosimetry
- Industrial Vision Systems and Defect Detection
- Relativity and Gravitational Theory
- Nanopore and Nanochannel Transport Studies
- Salivary Gland Disorders and Functions
- Airway Management and Intubation Techniques
- Advanced Drug Delivery Systems
- Medical Imaging Techniques and Applications
- RNA modifications and cancer
- Traumatic Ocular and Foreign Body Injuries
Heilongjiang University of Chinese Medicine
2024
East China University of Science and Technology
2011-2022
China Medical University
2021-2022
China Medical University Hospital
2021-2022
Institute of Modern Physics
2010-2021
Hiroshima University
2021
University of California, Los Angeles
2018-2020
Sun Yat-sen University
2020
Sun Yat-sen University Cancer Center
2020
Brown Foundation
2015
Highlights•We corrected the mutant CFTR gene in cystic fibrosis iPSCs•Correction restored protein expression and function iPSC-derived epithelial cells•We observed an exquisitely sensitive, homology-dependent, allele-preferred targetingSummaryRecently developed reprogramming genome editing technologies make possible derivation of patient-specific pluripotent stem cell sources—potentially useful for development new therapeutic approaches. Starting with skin fibroblasts from patients diagnosed...
In this paper we analyze the process ${B}_{s}\ensuremath{\rightarrow}{l}^{+}{l}^{\ensuremath{-}}$ in a type-II two-Higgs-doublet model (2HDM) and minimal supersymmetric standard (MSSM). All leading terms of Wilson coefficients relevant to are given large $\mathrm{tan}\ensuremath{\beta}$ limit. It is shown that decay width for depends on all parameters except ${m}_{{A}^{0}}$ 2HDM. The branching ratio ${B}_{s}\ensuremath{\rightarrow}{\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$...
Biomarkers are needed for noninvasive early detection of gastric cancer (GC). We investigated salivary extracellular RNA (exRNA) biomarkers as potential clinical evaluation tools GC.Unstimulated whole saliva samples were prospectively collected from 294 individuals (163 GC and 131 non-GC patients) who underwent endoscopic at the Samsung Medical Center in Korea. Salivary transcriptomes 63 31 patients profiled, mRNA biomarker candidates verified with reverse transcription quantitative...
It is shown that in supersymmetric models the large contributions to $\stackrel{\ensuremath{\rightarrow}}{B}{X}_{s}{\ensuremath{\mu}}^{+}{\ensuremath{\mu}}^{\ensuremath{-}}$ come from Feynman diagrams which consist of exchanging neutral Higgs boson loops and are proportional ${m}_{b}{m}_{\ensuremath{\mu}}{\mathrm{tan}}^{3}\ensuremath{\beta}{/m}_{h}^{2}$ when tan \ensuremath{\beta} mass lightest ${m}_{h}$ not too (say, less than 150 GeV). Numerical results show branching ratios can be...
Mutations identified in the epidermal growth factor receptor (EGFR) predict sensitivity to EGFR-targeted therapy for non-small cell lung carcinoma (NSCLC). We previously reported that Electric Field-Induced Release and Measurement (EFIRM)-based liquid biopsy could detect EGFR ctDNA with >94% concordance tissue-based genotyping. A side-by-side comparison of EFIRM droplet digital PCR (ddPCR) detection two front-line actionable EFGR mutations was performed paired plasma saliva samples from...
We study a model of scalars which includes both the SM Higgs and scalar singlet as composites heavy vector-like fermions. The fermions are bounded by super-strong four-fermion interactions. decays to vector bosons through loop show that surprisingly large production cross section di-photon events at 750 GeV resonance odd decay properties can all be explained. This serves good for GeV.
The invariant mass spectrum, forward-backward asymmetry, and lepton polarizations of the exclusive processes $B\to K(K^*)\ell^+ \ell^-, \ell=\mu, \tau$ are analyzed under supersymmetric context. Special attention is paid to effects neutral Higgs bosons (NHBs). Our analysis shows that branching ratio process $\bkm$ can be quite largely modified by asymmetry would not vanish. For $\bksm$, transverse polarization sensitive NHBs, while longitudinal not. both $\bkt$ $\bkst$, NHBs significant....
The stabilization and processing of salivary transcriptome proteome biomarkers is a critical challenge due to the ubiquitous nature nucleases proteases as well inherent instability these biomarkers. Furthermore, extension analysis point-of-care remote sites requires availability self-administered ambient temperature collection storage tools. To address challenges, self-contained whole saliva extraction system, RNAPro•SAL, has been developed that provides rapid along with concurrent...
We study dark matter (DM) in the model with one keV scale right-handed neutrino ${\ensuremath{\nu}}_{R1}$ and two GeV neutrinos ${\ensuremath{\nu}}_{R2,3}$, $\ensuremath{\nu}\mathrm{SM}$. find that of can have a much longer lifetime than other when are degenerate. show mass mixing light be explained this case. Significant entropy release generated reheating produced by decay ${\ensuremath{\nu}}_{R}$. The density DM diluted 2 orders magnitude, active is allowed to larger, reaching bound from...
Electric field–induced release and measurement (EFIRM) is a novel, plate-based, liquid biopsy platform capable of detecting circulating tumor DNA containing EGFR mutations directly from saliva plasma in both early- late-stage patients with non–small-cell lung cancer. We investigated the properties target molecule for EFIRM determined that preferentially detects single-stranded molecules. then assay linearity, linear range, precision, limit detection six different variants (the four most...
Background: We assessed whether serial ctDNA monitoring of plasma and saliva predicts response resistance to osimertinib in EGFR-mutant lung adenocarcinoma. Three technologies-blood-based droplet-digital PCR (ddPCR), next-generation sequencing (NGS), saliva-based EFIRM liquid biopsy (eLB)-were employed investigate their complementary roles. Methods: Plasma samples were collected from patients enrolled a prospective clinical trial local ablative therapy upon progression (NCT02759835). was...
The aim of the present study was to fabricate a
The constraints of electric dipole moments (EDMs) the electron and neutron on parameter space in supergravity (SUGRA) models with nonuniversal gaugino masses are analyzed. It is shown that, a light sparticle spectrum, sufficient cancellation calculation EDMs can happen for all phases order 1 small $\mathrm{tan}\ensuremath{\beta}$ case but ${\ensuremath{\varphi}}_{\ensuremath{\mu}}$ $(|{\ensuremath{\varphi}}_{\ensuremath{\mu}}|\ensuremath{\lesssim}\ensuremath{\pi}/6)$ large case. This...
Direct CP asymmetries and the violating normal polarization of lepton in inclusive decay B \to X_s l^+ l^- are investigated minimal supergravity model with phases. The contributions coming from exchanging neutral Higgs bosons included. It is shown that direct violation branching ratio, A_{CP}^1, {\cal{O}}(10^{-3}) for l=e, \mu, \tau. l=\mu can reach 0.5 percent when tan\beta large (say, 36). For l=\tau case \tan\beta, backward-forward asymmetry, A_{CP}^2, one percent, \tau be as a few both...
We study the possible origin of Friedberg-Lee symmetry. First, we propose generalized symmetry in potential by including scalar fields field transformations, which can be broken down to spontaneously. show that allows a typical form Yukawa couplings, and realistic neutrino masses mixings generated via seesaw mechanism. If right-handed neutrinos transform nontrivially under symmetry, have testable TeV scale Second, present two models with $SO(3)\ifmmode\times\else\texttimes\fi{}U(1)$ global...
We give a perturbation theory of neutrino oscillation in the Earth. The is valid for neutrinos with energy $E\ensuremath{\gtrsim}0.5\text{ }\text{ }\mathrm{GeV}$. It formulated using trajectory dependent average potential. Nonadiabatic contributions are included as first order effects theory. analyze standard matter effect and nonstandard effect. In three flavor analysis we show that gives precise description conversion Earth substantially simplified this formulation.
We study the production of heavy sterile neutrino $N$, $e^+ e^- \to N \nu({\bar \nu})$, at Circular Electron Positron Collider(CEPC) and its $ljj$ signal in decay to three charged fermions. background events for this process which are mainly coming from W pair production. a single sensitivity CEPC mixing with active neutrinos. two degenerate neutrinos low energy see-saw model by taking into account constraints on mixings neutrino-less double $\beta$ experiment masses show that under proposal...
The Friedberg-Lee (FL) symmetry is generated by a transformation of fermionic field $q$ to $q + ξz$. This puts very restrictive constraints on allowed terms in Lagrangian. Applying this $N$ fields, we find that the number independent fields reduced $N-1$ if have gauge interaction or local one. Using property, seesaw model originally with three generations left- and right-handed neutrinos, left-handed neutrinos unaffected but transformed under FL translation, an effective theory minimal which...
We study Earth matter effect in oscillations of supernovae neutrinos. show that detecting gives an independent measurement spectra neutrinos, i.e., the flavor difference energy resolution and angular a final electron or positron on signal effect. varying widths bins analysis can change strength statistical fluctuation. A reasonable choice both suppress fluctuation make good relative to Neutrino detectors with are therefore preferred so there is more freedom vary optimize analyzing events
We study the possibility that light dark matter can be produced with right relic density by decay of other sector particles. this in a model right-handed neutrinos, singlet scalar and fermion. The heavier gives rise to lighter fermion which serves as candidate. show scalar. find mass GeV scale or MeV interaction is very weak. have GeV-TeV weak interactions Standard Model (SM) So, scenario, has an SM much weaker than interaction, but still SM.
It is shown that in the approximation of |q/p|=1 CP violation B0d,s→l+l− decays vanishes SM. In a 2HDM with violating phases and MSSM asymmetries depend on parameters models can be as large 40% for B0d 3% B0s. An observation asymmetry would unambiguously signal existence new physics.