A5007387613- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Analysis
- Synthesis and biological activity
- Synthesis of heterocyclic compounds
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Synthesis and Biological Evaluation
- Catalytic C–H Functionalization Methods
- Synthesis and Reactivity of Heterocycles
- Advanced battery technologies research
- Fluorine in Organic Chemistry
- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Advanced Battery Technologies Research
- Synthesis and Characterization of Heterocyclic Compounds
- Crystallography and molecular interactions
- Radical Photochemical Reactions
- Oxidative Organic Chemistry Reactions
- Synthesis of Organic Compounds
- Chemical Reaction Mechanisms
- Fuel Cells and Related Materials
- Synthesis and Reactions of Organic Compounds
- Advanced Battery Materials and Technologies
N.D. Zelinsky Institute of Organic Chemistry
2018-2024
Electrochemical synthesis suggested a mild, green and atom-efficient route to interesting useful molecules, thus avoiding harsh chemical oxidizing reducing agents used in traditional synthetic methods. Organic electrochemistry offers an excellent alternative conventional methods of organic creates modern tool for carrying out synthesis, including cascade multicomponent ones. In this research, novel electrocatalytic transformation was found: the electrochemical assembly arylaldehydes,...
The multicomponent reaction of aldehydes, cyano-containing C-H acids, esters 3-oxocarboxylic acid and ammonium acetate led to unexpected results. boiling starting materials in methanol for one two hours resulted the formation polysubstituted 1,4,5,6-tetrahydropyridines with or three stereogenic centers. During 2020 lockdown, we obtained key intermediates this six-step domino reaction. A number fast slow reactions occurred during prolonged stirring mass at rt. Sequence: 1. Knoevenagel...
The Knoevenagel-Michael-Mannich-cyclization cascade of aldehydes, cyano-containing C-H acids, ethyl 4,4,4trifluoro-3-oxobutanoate and ammonium acetate provided convenient stereoselective formation 5,5dicyano-4,6-diaryl-2-hydroxy-2-(trifluoromethyl)pi-peridine-3-carboxylates with four stereogenic centers dialkyl 4,6-diaryl-5-cyano-2-hydroxy-2-(trifluoromethyl)piperidine-3,5-dicarboxylates five centers.The individual diastereomers was shown.The configuration confirmed by NMR spectra X-ray...