A5055003684- Bacillus and Francisella bacterial research
- Dietetics, Nutrition, and Education
- Bacteriophages and microbial interactions
- Obesity and Health Practices
- Bacterial Genetics and Biotechnology
- Innovations in Medical Education
- Nutrition and Health in Aging
- Vibrio bacteria research studies
- COVID-19 Impact on Reproduction
- Viral Infections and Outbreaks Research
- Yersinia bacterium, plague, ectoparasites research
- Viral gastroenteritis research and epidemiology
- Health Sciences Research and Education
- Gut microbiota and health
- Protein Structure and Dynamics
- Educational Assessment and Pedagogy
- COVID-19 and Mental Health
Commonwealth Medical College
2022-2024
Wichita State University
2014-2022
Protective antigen (PA) mediates entry of edema factor (EF) and lethal (LF) into the cytoplasmic space cells through formation a membrane-spanning pore. To do this, PA must initially bind to host cellular receptor. Recent mass spectrometry analysis using histidine hydrogen-deuterium exchange (His-HDX) has shown that binding von Willebrand A (vWA) domain receptor capillary morphogenesis protein-2 (CMG2) lowers rates imidazole C2 hydrogen several histidines, suggesting decreases structural...
The major immunogenic component of the current anthrax vaccine, vaccine adsorbed (AVA) is protective antigen (PA). We have shown recently that thermodynamic stability PA can be significantly improved by binding to Von-Willebrand factor A (VWA) domain capillary morphogenesis protein 2 (CMG2), and improvements in may improve storage long-term for use as a vaccine. In order understand origin this increase stability, we isolated receptor PA, 4 (D4), studied effect addition CMG2 on stability. are...
<title>Abstract</title> <bold>Background: </bold>The American Society of Clinical Nutrition recommends 37 to 44 hours undergraduate medical nutrition education. The Total Health Curriculum at Geisinger Commonwealth School Medicine (GCSOM) contains 14 objective-based nutritional instruction. This study aimed examine the perceptions key stakeholders regarding role in medicine and identify barriers, opportunities for improvement, roles/responsibilities innovative implementation <bold>Methods:...
Objectives: Nutrition education content in Geisinger Commonwealth School of Medicine's Total Health Curriculum falls short national recommendations with 14 hours instruction predominating the preclinical phase and centered on basic sciences. The nutrition fails to emphasize chronic disease prevention lacks continuity between formal clinical instruction. We performed a qualitative assessment determine perceived gaps, beliefs, competencies from stakeholders solicit their suggestions for...
The American Society of Clinical Nutrition recommends 37 to 44 h undergraduate medical nutrition education. Total Health Curriculum at Geisinger Commonwealth School Medicine (GCSOM) contains 14 objective-based nutritional instruction. This study aimed examine the perceptions key stakeholders regarding role in medicine and identify barriers, opportunities for improvement, roles/responsibilities innovative implementation
The anthrax toxin PA is the major immunogen in current vaccine (anthrax adsorbed). Improving for avoidance of a cold chain necessitates improvements thermodynamic stability PA. We address how stabilizing using sCMG2 affects immunogenicity BALB/c mice. Although increased by binding to sCMG2, decreased. This study emphasizes that, while ligand retains or improves conformational without affecting native sequence, epitope recognition processing may be affected, abrogating an effective immune response.
PURPOSE Conceptual frameworks have demonstrated better learning outcomes in undergraduate medical education (UME). We propose developing a conceptual framework based upon core concepts (CCs) biomedical sciences to link the progression of student program objectives recently revised UME curriculum. METHODS Our project involves three steps. Step 1 identifies clinically relevant CCs pertinent basic science disciplines. 2 tags multiple choice questions (MCQs) allowing us follow students’ across...