A5022681129- Folate and B Vitamins Research
- RNA Research and Splicing
- Allergic Rhinitis and Sensitization
- Pancreatitis Pathology and Treatment
- Asthma and respiratory diseases
- Birth, Development, and Health
- Dermatology and Skin Diseases
- Pancreatic and Hepatic Oncology Research
- Bioinformatics and Genomic Networks
- Biomedical Text Mining and Ontologies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Health, Environment, Cognitive Aging
- Genomics and Chromatin Dynamics
- Gene expression and cancer classification
Icahn School of Medicine at Mount Sinai
2019-2024
Identifying the transcription factors (TFs) responsible for observed changes in gene expression is an important step understanding regulatory networks. ChIP-X Enrichment Analysis 3 (ChEA3) a factor enrichment analysis tool that ranks TFs associated with user-submitted sets. The ChEA3 background database contains collection of set libraries generated from multiple sources including TF-gene co-expression RNA-seq studies, TF-target associations ChIP-seq experiments, and co-occurrence computed...
Abstract Background Birth defects are functional and structural abnormalities that impact about 1 in 33 births the United States. They have been attributed to genetic other factors such as drugs, cosmetics, food, environmental pollutants during pregnancy, but for most birth there no known causes. Methods To further characterize associations between small molecule compounds their potential induce specific abnormalities, we gathered knowledge from multiple sources construct a reproductive...
Abstract Introduction Tape‐strips, a minimally invasive method validated for the evaluation of several skin diseases, may help identify asthma‐specific biomarkers in children with allergic asthma. Methods Skin tape‐strips were obtained and analyzed RNA‐Seq from moderate asthma (MAA) ( n = 11, mean age 7.00; SD 1.67), severe (SAA) 9, 9.11; 2.37), healthy controls (HCs) 12, 7.36; 2.03). Differentially expressed genes (DEGs) identified by fold change ≥2 false discovery rate <0.05....
Abstract Birth defects are functional and structural abnormalities that impact 1 in 33 births the United States. have been attributed to genetic as well other factors, but for most birth there no known causes. Small molecule drugs, cosmetics, foods, environmental pollutants may cause when mother is exposed them during pregnancy. These molecules interfere with process of normal fetal development. To characterize associations between small compounds their potential induce specific...
Abstract Purpose Pancreatitis is one of the most important risk factors for pancreatic ductal adenocarcinoma (PDAC). PDAC a silent, aggressive malignancy that has less than 5% survival rate at 5 years. Detection early stage and resection significantly improves survival. A differentially expressed microRNA panel was sought could predict progression to from pancreatitis. Methods Differentially (DEM) in serum were common between pancreatitis extracted two microarray GSE datasets containing...