Medical therapies to avoid the progression of Alzheimer's disease (AD) are limited date. Certain diets have been associated with a lower incidence neurodegenerative diseases. In particular, regular intake foods rich in polyphenols, such as epicatechin (EC), could help prevent or mitigate AD progression. This work aims explore neuroprotective effects EC using different transgenic strains

The nematode Caenorhabditis elegans has been used to examine the influence of epicatechin (EC), an abundant flavonoid in human diet, some stress biomarkers (ROS production, lipid peroxidation and protein carbonylation). Furthermore, ability EC modulate expression key genes insulin/IGF-1 signaling pathway (IIS), involved longevity oxidative or heat shock response, also explored. final aim was contribute elucidation mechanisms biological effects flavonoids. results showed that EC-treated...

Currently, there is growing interest in extracts derived from winery by-products because of their beneficial health properties, which are associated with the presence bioactive compounds. In this paper, we have carried out chemical characterization and vitro colonic fermentation four grape pomace (GP) rich polyphenols dietary fibre.Firstly, phenolic fibre composition GP was determined. The highest individual concentrations corresponded to gallic ellagic acids, followed by catechins...

The aim of this work was to evaluate the biological activity four grape pomace (GP) extracts that are rich in polyphenols using C. elegans as an vivo model. Different concentrations GP were assessed for their effects on resistance against thermally induced oxidative stress, accumulation reactive oxygen species (ROS), and lifespan. cultivation with relatively low increased thermal stress prolonged lifespan, while high levels displayed detrimental effects. In studied extracts, maximum...

Quercetin is one the most abundant flavonoids in human diet. Although it well known that quercetin exhibits a range of biological activities, mechanisms behind these activities remain unresolved. The aim this work to progress knowledge molecular involved effects using Caenorhabditis elegans as model organism. With aim, nematode has been used explore ability flavonoid modulate insulin/insulin-like growth factor 1(IGF-1) signaling pathway (IIS) and expression some genes related stress...

Caffeic and dihydrocaffeic acid are relevant microbial catabolites, being described as products from the degradation of different phenolic compounds i.e., hydroxycinnamoyl derivatives, anthocyanins or flavonols. Furthermore, caffeic is found both in free esterified forms many fruits high concentrations coffee. These acids may be responsible for a part bioactivity associated with intake compounds. With aim progressing knowledge health effects mechanisms action dietary phenolics, model...

Anthocyanins have been associated with several health benefits, although the responsible mechanisms are not well established yet. In present study, an anthocyanin-rich extract from bilberry (Vaccinium myrtillus L.) was tested in order to evaluate its capacity modulate reactive oxygen species (ROS) production and resistance thermally induced oxidative stress, using nematode Caenorhabditis elegans as vivo model. The assays were carried out wild-type N2 strain mutant strains daf-16(mu86) I...

Increasing evidence supports the role of gut microbiota in many aspects human health, including immune, metabolic and neurobehavioral traits. Several studies have focused on how different components diet, such as polyphenols, can modulate composition function leading to health benefits. The effects resistance against thermally induced oxidative stress C. elegans grown presence flavonoids (quercetin or epicatechin) fed probiotic strains, namely Lactobacillus plantarum CLC17, Bifidobacterium...

The objective of this study was to evaluate the effects consuming 50 g raisins on cognitive performance, quality life, and functional activities in healthy older adults. This is a parallel randomized controlled clinical trial, which 80 subjects over 70 years age participated. For 6 months, intervention group (IG; n = 40) consumed per day added their usual diet, whereas control (CG; received no supplement. All variables were measured at baseline months. Cognitive performance assessed with...

Purpose: This study aimed to compare the effectiveness of EMG-biofeedback (EMG-BF), extracorporeal magnetic innervation (ExMI), and pelvic floor muscle training (PFMT) treatments on women with stress urinary incontinence (SUI). Materials Methods: The included 67 SUI. Pelvic muscles (PFMs) were evaluated electromyography quality life (QoL) Incontinence Quality Life (I-QoL) questionnaire; afterwards, subjects divided into three groups; EMG-BF group (n=23), ExMI (n=20), PFMT (n=24). given in...

A 33‐year‐old highly parous woman developed severe abdominal pain and signs of circulatory collapse 10 months after tubal sterilisation in the absence symptoms pregnancy. ruptured ectopic pregnancy sited interstitially right tube extending into myometrium parametrium was found at laparotomy. Histopathologic examination revealed an consisting choriocarcinoma ‐ a rare but life‐threatening combination sterilised woman.

Polyphenols exhibit a range of biological activities that have been associated to their ability detoxify radicals and repair oxidative damage [1]. The aim the present work was evaluate ROS production levels DNA in Caenorhabditis elegans submitted thermally-induced stress when it grown presence different flavonoids, i.e., epicatechin (EC), quercetin (Q) methylated metabolites: 3'-O-methylEC (3'MetEC) 4'-O-methylQ (tamarixetin, TMX). Levels intracellular were significantly reduced...

Alzheimer’s disease (AD), a major neurodegenerative disorder, is characterized by the progressive accumulation of amyloid-β (Aβ) plaques, leading to cognitive decline. Despite existing treatments, their limited efficacy highlights urgent need for novel therapeutic strategies. The present study investigates neuroprotective effects grape seed polyphenol extract (GSPE) on transgenic Caenorhabditis elegans models specifically expressing human Aβ proteins. obtained results show that GSPE not only...

Abstract The nematode Caenorhabditis elegans has been used to examine the influence of epicatechin (EC), an abundant flavonoid in human diet, some stress biomarkers (ROS production, lipid peroxidation and protein carbonylation). Furthermore, ability EC modulate expression key genes insulin/IGF-1 signaling pathway (IIS), involved longevity oxidative or heat shock response, also explored. final aim was contribute elucidation mechanisms biological effects flavonoids. results showed that...