A5071248937- Coronary Artery Anomalies
- Cardiac Valve Diseases and Treatments
- Congenital Heart Disease Studies
- Vascular Anomalies and Treatments
- Infective Endocarditis Diagnosis and Management
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Pulmonary Hypertension Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Arrest and Resuscitation
- Cardiovascular Issues in Pregnancy
- Tracheal and airway disorders
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Disease and Adiposity
- Cancer Immunotherapy and Biomarkers
- Adipose Tissue and Metabolism
- Medical Imaging and Pathology Studies
- Inhalation and Respiratory Drug Delivery
- Kawasaki Disease and Coronary Complications
- Mechanical Circulatory Support Devices
- Cardiovascular Conditions and Treatments
- Obesity, Physical Activity, Diet
- Cardiac Arrhythmias and Treatments
Roche (Switzerland)
2024
Hospitais da Universidade de Coimbra
2014-2022
Hospital Central da Polícia Militar
1999
Effective T-cell responses not only require the engagement of receptors (TCRs; "signal 1"), but also availability costimulatory signals ("signal 2"). bispecific antibodies (TCBs) deliver a robust signal 1 by engaging TCR signaling component CD3ε, while simultaneously binding to tumor antigens. The CD20-TCB glofitamab redirects T cells CD20-expressing malignant B cells. Although exhibits strong single-agent efficacy, adding may enhance depth and durability T-cell-mediated cell killing. We...
Background: Obesity-related comorbidities are present in young obese children, providing a platform for early adult cardiovascular disorders.Objectives: To compare and correlate markers of adiposity to metabolic disturbances, vascular cardiac morphology European pediatric cohort.Methods: We carried out an observational transversal analysis cohort consisting 121 children both sexes, between the ages 6 17 years.The control group consisted 40 with normal body mass index within same age...
Pediatric obesity is increasingly prevalent in the Portuguese population. Adipocyte dysfunction results expression of pro-inflammatory mediators that are responsible for low-grade inflammatory process characterizes obesity.The aim this study was to investigate relationship between markers adiposity, inflammation and adipokines a obese pediatric population.One hundred twenty children both sexes, aged 6-17 years, were included study. The control group consisted 41 healthy normal-weight...
Pediatric obesity is increasingly prevalent in the Portuguese population. Adipocyte dysfunction results expression of pro-inflammatory mediators that are responsible for low-grade inflammatory process characterizes obesity. The aim this study was to investigate relationship between markers adiposity, inflammation and adipokines a obese pediatric One hundred twenty children both sexes, aged 6–17 years, were included study. control group consisted 41 healthy normal-weight children. variables...
The authors describe the case of a newborn who, at 24 hours age, presented with respiratory distress, differential upper/lower limb oxygen saturations, cyanosis and filiform femoral pulses. He was started on prostaglandin E1 perfusion transferred to our centre. had signs lung
Abstract Coronary artery fistulae are uncommon but may be haemodynamically significant, being an incidental finding in 0.1–0.2% of coronary angiograms. Even rarer is the association between and non-atherosclerotic aneurysms. They most frequently originate right artery, cardiac chambers common draining chambers. Most children asymptomatic, whereas those older than 20 years present with signs congestive heart failure, infective endocarditis, myocardial ischaemia, or aneurysm rupture....
s p c t a e P Major aortopulmonary collateral arteries (MAPCAs) are anomalous vessels that develop from the aorta or its main branches and supply pulmonary parenchyma with oxygenated blood. They usually associated congenital heart disease rare in isolation. We report case of newborn girl, full term, no relevant history, whom III/VI murmur was detected on left sternal border first day life. At seven days remote cardiology consultation raised suspicion right inferior vein stenosis despite...
A diagnosis of congenital heart disease is usually established at an early age, so infective endocarditis a rare form presentation. The authors describe the case male adolescent with week-long history intermittent fever and unquantified weight loss. Physical examination detected pansystolic diastolic murmurs, associated precordial thrill. Laboratory tests showed evidence active infection. Etiological investigation revealed perimembranous ventricular septal defect, aortic regurgitation,...
A diagnosis of congenital heart disease is usually established at an early age, so infective endocarditis a rare form presentation. The authors describe the case male adolescent with week-long history intermittent fever and unquantified weight loss. Physical examination detected pansystolic diastolic murmurs, associated precordial thrill. Laboratory tests showed evidence active infection. Etiological investigation revealed perimembranous ventricular septal defect, aortic regurgitation,...
Os ferimentos penetrantes do torax representam 10 a20% de todas as admissoes hospitalares criancas vitimasde trauma e feridas por armas brancas sao responsaveispor cerca dois tercos dos traumatismoscardiacos abertos.Descreve-se o caso clinico um adolescente 17anos, vitima agressao arma branca. Manteve-sesempre hemodinamicamente estavel, sem alteracoessignificativas no exame fisico, com excecao tres feridasincisas couro cabeludo regioes inframamilar eperi-umbilical esquerdas. A avaliacao...
Abstract Percutaneous pulmonary valve implantation is a less invasive procedure to treat right outflow tract dysfunction related surgical procedures such as repair of Tetralogy Fallot. Despite the lower risks, complications have been reported, namely embolisation pre-stent. We report case 16-year-old boy, whose was complicated by pre-stents and strategy used reimplant them, prior successful valve.