A5065132759- Poisoning and overdose treatments
- Opioid Use Disorder Treatment
- Forensic Toxicology and Drug Analysis
- Drug-Induced Hepatotoxicity and Protection
- Pain Management and Opioid Use
- Prenatal Substance Exposure Effects
- Treatment of Major Depression
- Psychedelics and Drug Studies
- Anesthesia and Sedative Agents
- Suicide and Self-Harm Studies
- Cannabis and Cannabinoid Research
- Substance Abuse Treatment and Outcomes
- Alcoholism and Thiamine Deficiency
- Pharmacology and Obesity Treatment
- Immunotoxicology and immune responses
- Neurotransmitter Receptor Influence on Behavior
- Chemical synthesis and alkaloids
- Silymarin and Mushroom Poisoning
- Pharmaceutical studies and practices
- Pesticide Exposure and Toxicity
- Animal testing and alternatives
- Mental Health Treatment and Access
- Cardiac Arrest and Resuscitation
- Carcinogens and Genotoxicity Assessment
- Pharmaceutical Practices and Patient Outcomes
University of Rochester Medical Center
2014-2023
Strong Memorial Hospital
2013-2023
Clinical Research Consortium
2023
Society of Critical Care Medicine
2023
MedStar Washington Hospital Center
2023
Ballad Health
2023
Johnson City Medical Center
2023
Elmhurst Hospital Center
2021
Icahn School of Medicine at Mount Sinai
2021
University of Rochester
2013-2019
Illicit opioids, consisting largely of fentanyl, novel synthetic and adulterants, are the primary cause drug overdose fatality in United States. Xylazine, an alpha-2 adrenergic agonist veterinary tranquilizer, is being increasingly detected among decedents following illicit opioid overdose. Clinical outcomes non-fatal involving xylazine unexplored. Therefore, emergency department patients with overdose, we evaluated clinical outcome differences for without exposures.
Prescription opioid abuse is a major public health concern and an ongoing epidemic in the United States. Loperamide widely available inexpensive over-the-counter antidiarrheal with peripheral mu-opioid receptor activity. Online resources discuss use of loperamide for amelioration withdrawal symptoms or recreational abuse. We describe clinical course 5 patients abusing loperamide, 3 whom had life-threatening cardiac arrhythmias.In this observational case series, arrhythmias history were...
Abstract Background Near-term risk factors for suicidal behavior, referred to as ‘warning signs’ (WS), distinguish periods of acute heightened from lower within an individual. No prior published study has examined, using a controlled design, broad set hypothesized WS suicide attempt. This addressed this gap through examination behavioral/experiential, cognitive, and affective among patients recently hospitalized following Methods Participants were recruited during hospitalization five...
The rapid spread and mortality associated with COVID-19 emphasized a need for surveillance system development to identify adverse events (AEs) emerging therapeutics. Bradycardia is remdesivir infusion-associated AE listed in the US Food Drug Administration-approved prescribing information.To evaluate magnitude duration of bradycardic following administration.A multicenter cohort study patients recorded heart rate less than 60 beats per minute within 24 hours after administration dose was...
Background. Lipid emulsion is gaining popularity as an antidote for lipophilic drug overdose, and generally considered safe at doses recommended antidotal therapy. We report a case of asymptomatic pancreatitis following extended infusion lipid emulsion. Case report. A 14-year-old female presented to the emergency department actively seizing after ingesting 9 g bupropion unknown amounts hydroxyzine citalopram. She was intubated airway protection, gastrointestinal decontamination performed...
Context. We report the extraction of acetaminophen by continuous venovenous hemodiafiltration (CVVHD) during treatment an acute ingestion 200 g with a peak recorded serum level 1,614 mg/L (10,652 μmol/L). Case details. The patient presented early onset coma, metabolic acidosis, and hypotension in absence significant hepatic injury. In addition to N-acetylcysteine (NAC) therapy, CVVHD was performed manage acid–base disturbance. Flow rate, effluent volume, drug concentrations were obtained at...
Diphenhydramine (DPH) acts on peripheral and central histamine H1 receptors, causing reduction of allergic symptoms sedation, respectively.1 It is also a potent competitive antagonist muscarinic acetylcholine receptors can cause sinus tachycardia, xerostomia, mydriasis, blurred vision, ileus, urinary retention, CNS depression, agitation, hyperactivity, or psychosis. Given multiple potential mechanisms action its use for variety conditions, cases medication misuse abuse have been reported,2–5...
Ayahuasca is a hallucinogenic tea that most commonly comprised of the vine Banisteriopsis caapi alone or in combination with other plants such as Psychotria viridis . This concoction results an orally active form dimethyltryptamine (DMT), amine. Despite use South America medicinal agent and component religious ceremonies, interest its recreational spiritual effects has led to increased United States. We describe unique case following ingestion ayahuasca patient history schizophrenia...