A5114339820- Mitochondrial Function and Pathology
- Glaucoma and retinal disorders
- Ubiquitin and proteasome pathways
- Genomics and Phylogenetic Studies
- Shoulder Injury and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Nerve Injury and Rehabilitation
- Allergic Rhinitis and Sensitization
- Microbial Metabolism and Applications
- Coenzyme Q10 studies and effects
- Medical Imaging and Analysis
- Sarcoidosis and Beryllium Toxicity Research
- Peripheral Nerve Disorders
- Autophagy in Disease and Therapy
- Cerebrovascular and genetic disorders
- Plant Pathogens and Fungal Diseases
- Plant Disease Resistance and Genetics
- Moyamoya disease diagnosis and treatment
- Advancements in Transdermal Drug Delivery
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- Microbial Natural Products and Biosynthesis
- Orthopedic Surgery and Rehabilitation
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
Baylor College of Medicine
2025
Jeonbuk National University
2024
Mount Sinai Medical Center
2024
University of Miami
2020-2021
University of California, San Diego
2019-2020
United States Department of Veterans Affairs
2020
Albert Einstein College of Medicine
2017-2018
Jeju National University
2016
Abstract Impairment of mitochondrial structure and function is strongly linked to glaucoma pathogenesis. Despite the widely appreciated disease relevance dysfunction loss, molecular mechanisms underlying fragmentation metabolic stress in are poorly understood. We demonstrate here that glaucomatous retinal ganglion cells (RGCs) show loss A-kinase anchoring protein 1 (AKAP1), activation calcineurin (CaN) reduction dynamin-related (Drp1) phosphorylation at serine 637 (Ser637). These findings...
A pseudotumor of the tensor fascia lata (TFL) describes a rare condition characterized by hypertrophy or pseudohypertrophy TFL that can mimic soft tissue mass. Without right clinical suspicion, it be misdiagnosed as benign malignant tumor, leading to oncologic workups. Unnecessary workups cause patient distress, waste resources, and delay management its associated symptoms. Here, we describe 65-year-old male who developed in setting severe lumbar spinal stenosis. The etiology for this was...
Oxidative stress is one of major causal factors in glaucomatous neurodegeneration. Ubiquinol promotes retinal ganglion cell (RGC) survival against insults such as oxidative stress. Here we investigated the effect ubiquinol on RGC and/or visual function mouse models glaucoma and DBA/2J age-matched DBA/2J-Gpnmb+ (D2-Gpnmb+), which do not develop intraocular pressure elevation, or C57BL/6J mice were fed with (1%) control diet daily for 5 2 months. We assessed by Brn3a immunohistochemistry...
Introduction: Carpal tunnel syndrome is an entrapment neuropathy that affects 3% of adults in the United States. The current techniques used for diagnosis have limited specificity/sensitivity, and treatment efficacy. Case Report: A 34-year-old female presented to emergency department with two months worsening painful paresthesias her right thenar eminence. Ultrasound was performed showing a median nerve area 20.4 square millimeters within carpal tunnel. Median block causing complete resolution...
Molecular targeting for the altered signaling pathways has been proven to be effective treatment of many types human cancer, including colorectal cancer (CRC). The dual phosphatidylinositol-3-kinase (PI3K) and mammalian target rapamycin (mTOR) inhibitor BEZ235 shown exhibit potent antitumor activity against solid tumors. Autophagy is a cellular lysosomal catabolic process maintain metabolic homeostasis, which known induced in response therapeutic agents cells. This negatively regulated by...
Background. Myxofibrosarcoma (MFS) is notorious for its infiltrative growth pattern, making wide excisions difficult to achieve. Our objective was assess the impact of surgical margins and other factors that affected rates local recurrence (LR), distant metastasis (DM), overall survival (OS) individuals undergoing resection MFS. Methods. We retrospectively reviewed medical records 209 patients with appendicular soft tissue sarcomas between January 2012 June 2018. Of these, 29 (14%) were...
Strain CJN36-1N T , a Gram-stain-positive, non-flagellated, strictly aerobic and short rod-shaped bacterium, was isolated from flowerpot soil sampled in the Jeonju region of Republic Korea. Based on 16S rRNA gene sequences resulting phylogenetic tree, strain belonged to genus Microbacterium . contained chromosome 3.6 Mbp with G+C content 68.5 mol%. The grew at 10–37 °C (optimally 28 °C), pH 5.0–8.0 8.0), presence 0–7 % NaCl (w/v; optimally 0 NaCl). Digital DNA–DNA hybridization, average...
Objective: To describe the ocular manifestations of sarcoidosis in a South Florida population and identify risk factors for presence disease. Design: Retrospective consecutive case series. Methods: Medical charts individuals with seen University Miami pulmonary department were reviewed Odds ratios used to sarcoidosis. Results: Fourteen 108 had involvement. The mean age 14 was 56± 15 years. Seventy-one percent female, 50% black, 21% Hispanic. Twelve uveitis which panuveitis most common...
Abstract Impairment of mitochondrial structure and function is strongly linked to glaucoma pathogenesis. Despite the widely appreciated disease relevance dysfunction loss, molecular mechanisms underlying fragmentation metabolic stress in are poorly understood. We demonstrate here that glaucomatous retinal ganglion cells (RGCs) show loss A-kinase anchoring protein 1 (AKAP1), activation calcineurin (CaN) reduction dynamin-related (Drp1) phosphorylation at serine 637 (Ser637). These findings...