A5003032584- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Phosphodiesterase function and regulation
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Lichen and fungal ecology
- Obsessive-Compulsive Spectrum Disorders
- Gut microbiota and health
- Cholinesterase and Neurodegenerative Diseases
- Attention Deficit Hyperactivity Disorder
- Computational Drug Discovery Methods
- Autism Spectrum Disorder Research
- Nanoparticles: synthesis and applications
- Synthesis and biological activity
- PI3K/AKT/mTOR signaling in cancer
- Wnt/β-catenin signaling in development and cancer
- Child Nutrition and Feeding Issues
- Nigella sativa pharmacological applications
- Currency Recognition and Detection
- Molecular Sensors and Ion Detection
Erciyes University
2011-2025
Gazi Hastanesi
2020
Marmara University
2014-2018
Middle East Technical University
2011
Izmir Bozyaka Eğitim ve Araştırma Hastanesi
2009-2010
Izmir University
1998-2009
Günümüzde sosyal medya, bankacılık uygulamaları ve gelişmekte olan diğer teknolojiler cihazların büyük miktarda veri üretmesine neden olmaktadır. Bu verilerin kontrol, yönetim, bakım süreçleri güvenli bir şekilde paylaşılması gün geçtikçe daha da önem kazanmaktadır. Finans sektörünün liderliğinde depolama yönetim arayışlarına her geçen yeni bakış açısı veya teknoloji eklenmektedir. Bunun son en popüler örneklerinden biri Blok zinciri (Blockchain) teknolojisidir. Kripto para birimi Bitcoin’le...
In this work, the red pigment of Streptomyces sp. A23 strain isolated from Algerian bee pollen was used for green synthesis silver nanoparticles (AgNPs) as well evaluating their antimicrobial, anticancer, and neuroprotective activities. AgNPs were synthesized a result reduction 1 mM 5 nitrate solutions at various pH values (5, 7 9), subsequently characterized. (5 mM, 9) exhibited maximum UV-vis absorbance 433 nm. DLS revealed that average diameter 112 A zeta potential peak found -33 mV...
Ischemic stroke causes significant neuronal and glial cell damage. Recent studies suggest that stem cell-derived secretomes may offer therapeutic benefits for neural injuries. This study evaluates the protective effects of hair follicle (HFSC)-derived secretome on astrocytes subjected to oxygen-glucose deprivation (OGD), an in vitro model ischemic stroke. In this regard, primary astrocyte cultures were exposed OGD conditions 24 hours, followed by treatment with HFSC-derived 48 hours create...
Diabetes mellitus (DM) is one of the globally worst killer diseases. In this study, in vitro and vivo antidiabetic activity antioxidant capacity were determined phytochemical analyses carried out on flower extract sub-extracts
Abstract Background Several studies provide clear evidence that exposure to various infections during pregnancy are linked with an increased risk for schizophrenia. In preclinical studies, administration of polyinosinic‐polycytidylic acid (Poly I:C) in pregnant rodents can induce maternal immune activation leading impairments brain function the offspring. Objectives The aim this study was investigate effect vortioxetine, a multimodal selective serotonin reuptake inhibitor (SSRI),...
This study includes the synthesis of new Naproxen derivatives and in vitro – vivo molecular mechanistic studies.
This study aimed to investigate the neuroprotective role of probiotics and 1,25-dyhydroxyvitamin D
Nanoparticles, smaller than 100 nm are synthesized by chemical and physical methods. Biological synthesis of nanoparticles is very popular in science recently. The aim the study green zinc oxide (ZnO NPs) using lichen extract ( Ramalina fraxinea ) investigating cytotoxic effects ZnO NPs on human neuroblastoma cells (SHSY-5Y). Despite widespread use NPs, a limited number studies have investigated neurobiological NP. Therefore, we tested neurotoxic effect administration its neuroprotective...
First time in this study, neuroprotective or neurotoxic effects of Pseudevernia furfuracea and Usnea florida lichen extracts based silver decorated zinc oxide nanocomposites (Ag-ZnO NCs) were evaluated. The characteristic light absorption point P. U. Ag-ZnO NCs observed at 339 nm 361 nm; effective diameter was detected 342 495 nm. According to SEM analysis, the extract approximately 35 85 nm, respectively. When we examined toxicity SH-SY5Y against human neuroblastoma cells, it that have on a...
AIM: We aimed to determine the inter- and intra-observer variabilities between breast radiologists a general radiologist in categorizing mammographic lesions using Breast Imaging Reporting Data System (BI-RADS), evaluate effects of histopathologic results on variability. METHODS: Mammograms from 142 women who underwent biopsy were evaluated. 3 (2 with >10 years experience 1 year experience) retrospectively reviewed mammograms twice within an 8-week interval. Inter- assessed Cohen's kappa...
INTRODUCTION: Schizophrenia is one of the most severe psychiatric disorders with about 1% prevalence. It has been proved that glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonists such as MK-801 and phencyclidine cause schizophrenia-like behaviours in rodents. Agmatine an endogenous amine synthesized from decarboxylation arginine thought to be a neurotransmitter/neuromodulator. binds imidazoline alfa adrenergic receptors blocks cation channelled receptors, nicotinic acetylcholine,...
The design and detailing of reinforced concrete frames is a complex process that requires intensive real-time information exchange between various tasks. monolithic behavior concrete, differences in the geometric representation structural members during analysis stages, code requirements throughout add new dimensions to problem. Additionally, especially large projects, structures are designed detailed by several engineers simultaneously. These complexities can be resolved overall quality...
Glycogen synthase kinase-3 (GSK-3), a member of the serine/threonine kinase family was first identified as an inhibitor metabolic enzyme glycogen and is now accepted widely influential responsible for many intracellular regulatory mechanisms with over 50 known substrates characterized. There are two mammalian GSK-3 isoforms encoded by separate genes: GSK-3a GSK- 3β high structural homology. Both GSK-3β expressed in tissues highest levels brain their functions generally considered to be...
This study aimed to examine the effects of vortioxetine, a novel antidepressant, on epileptiform activity in pentylenetetrazole (PTZ)-induced kindling model rats. For this purpose, 20 male Wistar Albino rats were used, and was induced by injection PTZ (35 mg/kg, i.p., three times week). In vortioxetine groups, (5 mg/kg 10 mg/kg) administered before process. During process, Fisher Kittner seizure scales used score severity. After kindling, object recognition (NOR) tests performed evaluate...