During progression to heart failure (HF), myocardial extracellular matrix (ECM) alterations and tissue inflammation are central. Lumican is an ECM‐localized proteoglycan associated with inflammatory conditions known bind collagens. We hypothesized that lumican plays a role in the dynamic cardiac ECM during development of HF. Thus, we examined left ventricular mouse model pressure overload HF patients, investigated expression, regulation effects increased fibroblasts. After 4 weeks aortic...

In pressure overload, left ventricular (LV) dilatation is a key step in transition to heart failure (HF). We recently found that collagen VIII (colVIII), non-fibrillar and extracellular matrix constituent, was reduced hearts of mice with HF correlated degree dilatation. A reduction colVIII might be involved LV dilatation, we here examined the role overload-induced remodelling using knock-out (col8KO) mice. Col8KO exhibited increased mortality 3–9 days after aortic banding (AB) from day one...

ObjectivesThe use of unopposed oral anticoagulants while undergoing cardiothoracic surgery is associated with severe bleeding and increased morbidity. The aim this experimental study was to examine if the apixaban concentration in reconstituted blood could be reduced an vitro setup by CytoSorb whole adsorber, how affected global coagulation assays.Design SettingAn performed a laboratory.ParticipantsAn blood.InterventionsReconstituted spiked circulated circuit 300 mL device...

Abstract Aim: Myocardial remodelling during pressure overload might contribute to development of heart failure. Reverse normally occurs following aortic valve replacement for stenosis; however, the details and regulatory mechanisms reverse remain unknown. Thus, an experimental model would allow studies this process. Although models banding are widely used, only few reports debanding exist. The aim study was establish a banding–debanding in mouse with repetitive careful haemodynamic...

We define matching between ventricle and afterload to imply that the is adapted its yield maximum external work output. For ventricle, this optimal adaption will depend on end-diastolic dimension, heart rate, contractility. Because contractility impaired during ventricular failure, we propose load not as good failure normal conditions. According our definition, implies output less than maximum. Ventricle-load then present, i.e., a mismatch exists load. This hypothesis was tested in canine...

AimsAortic stenosis induces pressure overload and myocardial remodelling with concentric hypertrophy alterations in extracellular matrix (ECM). Aortic valve replacement leads to reverse remodelling, a process of which knowledge is scarce. The aims the present study were examine gene expression subsequently identify molecular important for early phase remodelling.

Blunt chest trauma might lead to cardiac injury ranging from simple arrhythmias lethal conditions such as rupture. We experienced a case of initially overlooked traumatic coronary artery dissection which resulted in acute myocardial infarction (AMI). A high degree suspicion is needed diagnose this condition. Based on our case, we will give an overview relevant literature topic. ECG, echocardiography, angiography and enzymes are valuable tools diagnosing rare The time span occlusion...

Left ventricular (LV) pressure overload leads to myocardial remodelling and reduced cardiac function. Both cardioprotective deleterious effects have been attributed SMAD2/3 (SMAD, small mothers against decapentaplegic) signalling, but the role of these important molecules in remains unclear. The aim this study was examine SMAD2 inhibition on function mice subjected aortic banding (AB), using a molecule inhibitor (SM16) signalling. C57BL/6 were 1 week AB, which led three-fold increased...

On the basis of role small, leucine-rich proteoglycans (SLRPs) in fibrogenesis and inflammation, we hypothesized that they could be involved cardiac remodeling reverse as occurs during aortic stenosis after valve replacement. Thus, a well-characterized banding-debanding mouse model, examined SLRPs decorin lumican enzymes responsible for synthesis their glycosaminoglycan (GAG) chains. Four weeks banding ascending aorta, mice were subjected to debanding operation (DB) subsequently followed 3...

Objectives. Assess the short- and long-term survival for patients who underwent isolated coronary artery bypass grafting (CABG) evaluate impact of gender age. Furthermore to assess in CABG group compared general population. Design. This study included 4044 consecutive at Oslo University Hospital, Ullevål, Oslo, Norway time period from 01 January 2003 31 December 2015. Patient data was collected retrospectively quality register department. Information on status obtained Norwegian National...

Hemolytic interference may impact various laboratory tests, including coagulation analyses. Apixaban is the most commonly used direct oral anticoagulant in Norway, and there lacking knowledge on how apixaban concentration measurements might be influenced by hemolysis. Moreover, hemolysis-induced alterations levels could potentially risk of bleeding specific clinical scenarios. We wanted to study whether hemolysis would increase investigate hemolytic measurements.

Aims The aim of this study was the analysis risk associated with direct oral anticoagulants (DOACs) in patients undergoing non-elective operations on proximal aorta due to aortic disease. Methods and results Data from department’s register cardiac surgery analysed retrospectively emphasis operative mortality. 135 for disease (October 2016 2018) were identified, which 19 died during first 90 days. DOAC use top-ranked factor univariate a HR 9.6 (3.1 29), p=0.00007. Using Cox proportional...

<b><i>Objectives:</i></b> Due to the pathological effects of endothelin-1 (ET-1) on cardiomyocytes and extracellular matrix, ET-1 levels may impact prognosis aortic stenosis (AS) patients operated with valve replacement (AVR). We examined in AS throughout whole AVR process, thus exposing potential therapeutic windows opportunity. <b><i>Methods:</i></b> Plasma were measured before 2 days, 6 12 months after 22 AS. Myocardial was biopsies from 7...

To examine the circulating levels of Growth differentiation factor 15 (GDF-15) and Interleukin 18 (IL-18) in relation to ischemia early reperfusion, cardioplegia type during isolated aortic valve replacement (AVR).Thirty consecutive patients operated for stenosis with AVR at Oslo University Hospital, Ullevål, were included study. The randomized into two groups, receiving either cold blood or crystalloid cardioplegia. Samples from both radial artery coronary sinus analyzed before cardiac...

Objectives. Patients with aortic stenosis (AS) develop left ventricular remodeling characterized by changes in extracellular matrix (ECM) and cardiomyocyte-hypertrophy. Aortic valve replacement (AVR) reverses this process (reverse remodeling). We examined plasma levels of interleukin-18 (IL-18) its binding protein (IL-18BP) before after AVR for AS since these mediators have been shown experimentally to exert effects on myocardial remodeling. Design. Plasma IL-18 IL-18BP were analyzed 22...

It is of great importance to identify molecular processes and pathways that are involved in disease etiology. Although there has been an extensive use various high-throughput methods for this task, pathogenic still not completely understood. Often the set genes or proteins identified as altered genome-wide screens show a poor overlap with canonical pathways. These findings difficult interpret, yet crucial order improve understanding underlying progression. We present novel method identifying...

Central MessageWe report the case of a 26-year-old male who presented with cardiogenic shock due to leaflet fracture and embolization from an On-X mitral valve prosthesis that had been implanted just 1 year earlier.See Commentary on page 144. We earlier. See Leaflet escape is dangerous but exceedingly rare complication modern mechanical heart valves. Whereas some older models (in particular, version Björk–Shiley tilting disc prosthetic valve) reported 3.9% cumulative incidence escape,1Blot...