A5057809101- Synthesis and Biological Evaluation
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Pyrroles
- Click Chemistry and Applications
- Ferrocene Chemistry and Applications
Rhodes University
2020-2021
A tailored series of coumarin-based ferrocenyl 1,3-oxazine hybrid compounds was synthesized and investigated for potential antiparasitic activity, drawing inspiration from the established biological efficacy constituent chemical motifs. The structural identity confirmed by common spectroscopic techniques: NMR, HRMS IR. Biological evaluation studies reveal that exhibit higher in vitro potency against chemosensitive malarial strain (3D7 P. falciparum) over trypanosomiasis causal agent (T. b....
With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort relatively unexplored arylpyrrole-based were synthesized in moderate to good yields. The resultant compounds evaluated vitro for their potential activity against cultured