A5002935377- Microfluidic and Capillary Electrophoresis Applications
- Biosensors and Analytical Detection
- Innovative Microfluidic and Catalytic Techniques Innovation
- Force Microscopy Techniques and Applications
- Advanced MEMS and NEMS Technologies
- Mechanical and Optical Resonators
- Microfluidic and Bio-sensing Technologies
- Advanced biosensing and bioanalysis techniques
- Electrowetting and Microfluidic Technologies
- Molecular Biology Techniques and Applications
- Analytical Chemistry and Sensors
- thermodynamics and calorimetric analyses
- Near-Field Optical Microscopy
- Electrochemical Analysis and Applications
- Photonic and Optical Devices
- SARS-CoV-2 detection and testing
- Transition Metal Oxide Nanomaterials
- Acoustic Wave Resonator Technologies
- Nanofabrication and Lithography Techniques
- Magnetic properties of thin films
- 3D Printing in Biomedical Research
- Integrated Circuits and Semiconductor Failure Analysis
- Nanowire Synthesis and Applications
- Advanced Biosensing Techniques and Applications
- Physiological and biochemical adaptations
Northwestern Polytechnical University
2016-2025
Brno University of Technology
2015-2024
Institute of Bioengineering and Nanotechnology
2004-2024
Central European Institute of Technology
2012-2022
Hong Kong University of Science and Technology
2020
University of Hong Kong
2020
KIST Europe
2011-2016
Center for Nanoscale Science and Technology
2016
Klinikum Saarbrücken
2015-2016
Korea Institute of Science and Technology
2012-2015
We report on the fabrication of nanometer-scale mass sensors with subattogram sensitivity. Surface micromachined polycrystalline silicon and nitride nanomechanical oscillators were used to detect presence well-defined loading. Controlled deposition thiolate self-assembled monolayers lithographically defined gold dots for calibrated a dinitrophenyl poly(ethylene glycol) undecanthiol-based molecule (DNP-PEG4-C11thiol) as model ligand this study. Due fact that is attached at distance l0 from...
The ability to detect small amounts of materials, especially pathogenic bacteria, is important for medical diagnostics and monitoring the food supply. Engineered micro- nanomechanical systems can serve as multifunctional, highly sensitive, immunospecific biological detectors. We present a resonant frequency-based mass sensor, comprised low-stress silicon nitride cantilever beams detection Escherichia coli (E. coli)-cell-antibody binding events with sensitivity down single cell. involved...
We have demonstrated high-sensitivity detection of bacteria using an array bulk micromachined resonant cantilevers. The biological sensor is a micromechanical oscillator that consists silicon-nitride cantilevers with immobilized antibody layer on the surface resonator. Measured frequency shift as function additional cell loading was observed and correlated to mass specifically bound Escherichia coli O157:H7 cells. Deposition subsequent E. cells achieved under ambient conditions.
We have designed, fabricated and tested a real-time PCR chip capable of conducting one thermal cycle in 8.5 s. This corresponds to 40 cycles 5 min The system was made silicon micromachined into the shape cantilever terminated with disc. thin film heater temperature sensor were placed on disc perimeter. Due system's constant 0.27 s, we achieved heating rate 175°C s−1 cooling −125°C s−1. A sample encapsulated mineral oil dispensed onto glass cover slip time then determined by heat transfer...
We present a low-cost miniaturized fluorescence detection system for lab-on-a-chip applications with sensitivity in the low nanomolar range; built-in lock-in amplifier enables measurements under ambient light.
World's smallest, fully autonomous, handheld real-time PCR was shown in this contribution. The device can quickly process up to four samples at a time with detection capability of single DNA copy. integrated system includes all required electronics for fluorescence measurement, data viewing (LCD display) and processing, is ideal use small clinics point-of-care applications.
For whom the bell tolls: Surface-functionalized superparamagnetic particles emulsified in mineral oil turn a free-standing droplet into flexible virtual laboratory with (sub)microliter volumes. By using magnetic forces, rare acute monocytic leukaemia cells are extracted from blood, preconcentrated, purified, lysed, and subjected to real-time PCR minutes. The works like clockwork by rotating over different temperature zones. Supporting information for this article is available on WWW under...
Herein we demonstrate giant piezoresistance in silicon nanowires (NWs) by the modulation of an electric field-induced with external electrical bias. Positive bias for a p-type device (negative n-type) partially depleted NWs forming pinch-off region, which resembled funnel through current squeezed. This region determined total flowing NWs. In this report, combined biasing application mechanical stress, impacts charge carriers' concentration, to achieve electrically controlled nanowires....
The in vitro study of liver functions and cell specific responses to external stimuli deals with the problem preserve vivo primary hepatocytes. In this study, we used biochip OrganoPlate(TM) (MIMETAS) that combines different advantages for cultivation hepatocytes vitro: (1) perfusion flow is achieved without a pump allowing easy handling placement incubator; (2) phaseguides allow plating matrix-embedded cells lanes adjacent physical barrier; (3) matrix-embedding ensures indirect contact...
This article introduces in archival form the Nanolithography Toolbox, a platform-independent software package for scripted lithography pattern layout generation.The Center Nanoscale Science and Technology (CNST) at National Institute of Standards (NIST) developed Toolbox to help users CNST NanoFab design devices with complex curves aggressive critical dimensions.Using parameterized shapes as building blocks, allows rapidly nanoscale arbitrary complexity through scripting programming.The...