A5086966132- Intracranial Aneurysms: Treatment and Complications
- Advanced Electron Microscopy Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Lysosomal Storage Disorders Research
- Cerebrovascular and Carotid Artery Diseases
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Moyamoya disease diagnosis and treatment
- Neurological diseases and metabolism
- Epigenetics and DNA Methylation
- Parathyroid Disorders and Treatments
- Aortic Disease and Treatment Approaches
- Pluripotent Stem Cells Research
- Radiomics and Machine Learning in Medical Imaging
- Neuroblastoma Research and Treatments
- Vascular Malformations Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Neurogenetic and Muscular Disorders Research
- Genetic and Kidney Cyst Diseases
- Cardiovascular and Diving-Related Complications
Rutgers, The State University of New Jersey
2020-2024
Robert Wood Johnson University Hospital
2024
Neurological Surgery
2024
Johnson University
2024
National Institute on Aging
2022-2023
National Institutes of Health
2022-2023
Abstract Parkinson’s disease has a large heritable component and genome-wide association studies have identified over 90 variants with disease-associated common variants, providing deeper insights into the biology. However, there not been large-scale rare variant analyses for disease. To address this gap, we investigated genetic of at minor allele frequencies <1%, using whole genome exome sequencing data from 7184 cases, 6701 proxy cases 51 650 healthy controls Accelerating Medicines...
Abstract α-Klotho (α-Kl) is a modulator of aging, neuroprotection, and cognition. Transcription the Klotho gene produces two splice variants—a membrane protein (mKl), which can be cleaved released into extracellular milieu, truncated secreted form (sKl). Despite mounting evidence supporting role for α-Kl in brain function, specific roles isoforms neuronal development remain elusive. Here, we examined levels rat observed region-specific expression adult that differs between isoforms. In...
Abstract Parkinson’s disease (PD) has a large heritable component and genome-wide association studies to date have identified over 90 variants associated with PD, providing deeper insights into the biology. However, there not been large-scale rare variant analyses for PD. To address this gap, we investigated genetic of PD at minor allele frequencies <1%, using whole genome exome sequencing data from 7,184 cases, 6,701 proxy-cases, 51,650 healthy controls Accelerating Medicines Partnership...
INTRODUCTION: Carotid stenosis causes 10-20% of cases with ischemic stroke. Research in this clinical domain continues to progress improving possible treatment modalities, imaging mechanistic understandings, and risk factors. METHODS: The WebOfScience database was investigated for 6,639 publication items between 2012-2022 pertaining neurosurgical management carotid stenosis. Networks were constructed analyzing keywords, key terms, countries publication. Subsequently, within each network...