A5007386113- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Muscle metabolism and nutrition
- Biochemical effects in animals
- Neurological Disorders and Treatments
- Cholinesterase and Neurodegenerative Diseases
- Birth, Development, and Health
- Neonatal and fetal brain pathology
- NF-κB Signaling Pathways
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Dementia and Cognitive Impairment Research
- Circadian rhythm and melatonin
- Functional Brain Connectivity Studies
- Traumatic Brain Injury Research
- Retinoids in leukemia and cellular processes
- Diet and metabolism studies
- Immune Response and Inflammation
- Neuroinflammation and Neurodegeneration Mechanisms
University of Manitoba
2014-2024
St. Boniface Hospital
2014-2024
Alzheimer’s disease (AD) is a major public health concern worldwide. Advanced age and female sex are two of the most prominent risk factors for AD. AD characterized by progressive neuronal loss, especially in cortex hippocampus, mitochondrial dysfunction has been proposed to be an early event onset progression disease. Our results showed perturbations function 3xTg mouse brain, with being more susceptible changes than hippocampus. In females, decreased coupled uncoupled respiration were...
The brain has a high demand for energy, of which creatine (Cr) is an important regulator. Studies document neurocognitive benefits oral Cr in mammals, yet little known regarding their physiological basis. This study investigated the effects supplementation (3%, w/w) on hippocampal function male C57BL/6 mice, including spatial learning and memory Morris water maze oxygen consumption rates from isolated mitochondria real time. Levels transcription factors related proteins (CREB, Egr1, IκB to...
The creatine (Cr) energy system has been implicated in Alzheimer’s disease (AD), including reductions brain phosphoCr and Cr kinase, yet no studies have examined the neurobehavioral effects of supplementation AD, 3xTg mouse model. This studied investigated on spatial cognition, plasticity- disease-related protein levels, mitochondrial function hippocampus. Here, mice were fed a control or Cr-supplemented (3% (w/w)) diet for 8–9 weeks tested Morris water maze. Mitochondrial oxygen consumption...
Objectives Although choline is essential for brain development and neural function, the effect of on retina function not well understood. This study examined effects tissues retina, membrane phospholipid (PL) composition during fetal development.Methods Pregnant C57BL/6 mice were fed one 4 modified diets: i) control (Cont, 2.5g/kg), ii) deficient (Def, 0g/kg), iii) supplemented with chloride (Cho, 10g/kg) iv) egg phosphatidylcholine (PC, 10g/kg). At postnatal day (PD) 21, pups weaned onto...
Oscillatory activity is inherent in many types of normal cellular function. Importantly, oscillations contribute to network and decision making, which are driving forces for cognition. Theta have been correlated with learning memory encoding gamma associated attention working memory. NMDA receptors also implicated oscillatory function disease-related pathology. The interplay between intellectually curious a fascinating dimension inquiry. In this review we introduce some the essential...
Abstract Background Mitochondrial bioenergetics are essential for cellular function, specifically the intricacies of electron transport chain (ETC), with Complex IV playing a crucial role in unraveling mechanisms governing energy production. Mathematical models offer valuable approach to simulate these complex processes, providing insights into normal mitochondrial function and aberrations associated various diseases, including neurodegenerative disorders. Our research focuses on introducing...