A5103032911- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gallbladder and Bile Duct Disorders
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related cognitive impairment studies
- Multiple Myeloma Research and Treatments
- Critical Race Theory in Education
- Higher Education Research Studies
- Chronic Myeloid Leukemia Treatments
- HIV/AIDS Research and Interventions
- Nonmelanoma Skin Cancer Studies
- RNA Interference and Gene Delivery
- Minimally Invasive Surgical Techniques
- Biliary and Gastrointestinal Fistulas
- Virus-based gene therapy research
- Glioma Diagnosis and Treatment
- Surgical Simulation and Training
- Advanced Biosensing Techniques and Applications
- DNA Repair Mechanisms
- Service-Learning and Community Engagement
- Cutaneous lymphoproliferative disorders research
- Family Dynamics and Relationships
The University of Texas MD Anderson Cancer Center
2020-2025
University of Iowa
2024
University of California, Riverside
2015-2023
Longevity Biotech (United States)
2023
University of California, Davis
1988-2019
University of Florida
2018-2019
Howard University
2019
Florida College
2018
Wilford Hall Ambulatory Surgical Center
2006
Brooke Army Medical Center
2005-2006
To determine the potential for mechanical stimulation of skeletal muscle to contribute reflex cardiovascular response static contraction (exercise reflex), we examined effects caused by either passive stretch or external pressure applied triceps surae muscles. First, were stretched an average developed tension 4.8 +/- 0.3 kg. This resulted in increases mean arterial (MAP) 28 7 mmHg, dP/dt 1,060 676 mmHg/s, and heart rate (HR) 6 2 beats/min (P less than 0.05). Additionally, increments 0.3,...
The Cornell Assessment for Pediatric Delirium (CAPD) was first proposed by the Acute Lung Injury and Sepsis Investigators Network-Stem Cell Transplantation Cancer Immunotherapy Subgroup MD Anderson CARTOX joint working committees, detection of immune effector cell associated neurotoxicity (ICANS) in pediatric patients receiving chimeric antigen receptor (CAR) T-cell therapy. It subsequently adopted American Society Cellular Therapy. utility CAPD as a screening tool early diagnosis ICANS has...
The use of Hypomethylating agents combined with Venetoclax (VH) for the treatment Acute Myeloid Leukemia (AML) has greatly improved outcomes in recent years. However not all patients benefit from VH regimen and a way to rationally select between Conventional Chemotherapy (CC) individual AML is needed. Here, we developed proteomic-based triaging strategy using Reverse-phase Protein Arrays (RPPA) optimize therapy selection. We evaluated expression 411 proteins 810 newly diagnosed adult...
Background: The incidence of gallstones increases with age and as the proportion population 65 years older continues to grow, increased demand for laparoscopic cholecystectomy (LC) in geriatric is likely. LC has advantages over open cholecystectomy, but comparative evaluation procedure elderly patients lacking. Methods: We performed a two-year review undergoing at our institution. Demographic information, diagnosis, operation performed, operative complications were recorded. Patients placed...
Abstract IL-23 receptor (IL-23R) is canonically a T cell surface cytokine known for its role in inflammatory diseases. In this study, we demonstrated that IL-23R localizes intracellularly AML where it regulates mitotic spindle formation. Differential gene expressions were analyzed samples compared to normal controls. Of the upregulated processes, ontology was most enriched. Analyzing all protein coding genes their correlation surprisingly returned as top hit. We confirmed expression 7 of...
The introduction of highly active antiretroviral therapy (HAART) has resulted in a significant increase life expectancy for HIV patients. Indeed, 2015, 45% the 1.2 million HIV+ individuals United States were 55 years age or older. Despite improvement diagnosis and treatments infection, geriatric patients suffer from higher incidence comorbidities compared to age-matched HIV- individuals. Both chronic inflammation dysbiosis gut microbiome are believed be major contributors this phenomenon,...
The survival of malignant leukemic cells is dependent on DNA damage repair (DDR) signaling. Reverse Phase Protein Array (RPPA) data sets were assembled using diagnostic samples from 810 adult and 500 pediatric acute myelogenous leukemia (AML) patients probed with 412 296 strictly validated antibodies, respectively, including those detecting the expression proteins directly involved in DDR. Unbiased hierarchical clustering identified strong recurrent DDR protein patterns both AML. Globally,...
Based on current AJCC-7 guidelines for staging cutaneous squamous cell carcinoma (cSCC), patients with T2 tumor represent a prognostically heterogeneous group. The new AJCC-8 seek to provide improved stratification by inclusion of independent risk factors in the T3 category. These features may be identified tissue stages during Mohs micrographic surgery (MMS). Thus, low-risk cSCC upstaged after MMS, impacting prognosis, additional evaluation, and adjuvant nonsurgical treatment.To examine...
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy that continues to have poor prognosis despite recent therapeutic advances. Venetoclax (Ven), a BCL2-inhibitor has shown high response rate in AML; however, relapse invariable due mitochondrial dysregulation includes upregulation of the antiapoptotic protein MCL1, central mechanism Ven resistance (Ven-res). We previously demonstrated transcription factor STAT3 upregulated AML hematopoietic stem and progenitor cells (HSPCs)...
Abstract Purpose The endoplasmic reticulum (ER) is the major site of protein synthesis and folding in cell. ER‐associated degradation (ERAD) unfolded response (UPR) are main mechanisms ER‐mediated cell stress adaptation. Targeting a promising therapeutic approach acute myeloid leukemia (AML). Experimental Design Protein expression levels valosin‐containing (VCP), chief element ERAD, were measured peripheral blood samples from 483 pediatric AML patients using reverse phase array methodology....
Abstract To identify novel biological vulnerabilities in AML, we searched for gene ontologies that were upregulated AML compared to normal hematopoietic cells. Of the processes, mitotic spindle ontology was a top hit. Unexpectedly, expression of IL-23 receptor (IL-23R) showed strong positive correlation with ontology. IL-23R is cell surface cytokine canonically expressed on T cells, but not known have role AML. In 7 tested lines and 15 20 primary patient samples, protein >2 fold...
DNA damage response (DNADR) recognition and repair (DDR) pathways affect carcinogenesis therapy responsiveness in cancers, including leukemia. We measured protein expression levels of 16 DNADR DDR proteins using the Reverse Phase Protein Array methodology acute myeloid (AML) (n = 1310), T-cell lymphoblastic leukemia (T-ALL) 361) chronic lymphocytic (CLL) 795) cases. Clustering analysis identified five clusters; three were unique compared to normal CD34+ cells. Individual differed by disease...
The use of flexible bronchoscopy (FB) with bronchoalveolar lavage (BAL) to diagnose and manage pulmonary complications has been shown be safe in adult cancer patients, but whether its is pediatric patients remains unclear. Thus, describe the landscape FB outcomes help define populations most likely benefit from procedure, we undertook a retrospective review FBs performed younger than 21 years treated at our institution 2002 2017. We found that greater volume total fluid instilled during BAL...
Introduction Immune effector cell associated neurotoxicity (ICANS) and cytokine release syndrome (CRS) are unique potentially life-threatening complications with immune (IEC) therapies. ICANS presents varying symptoms ranging from confusion to seizure cerebral edema. There is no consensus on the precise pathophysiology related ICANS. The incidence of this toxicity may vary based specific product, underlying diagnosis host factors. Here, we characterize in pediatric adult young adolescent...
Abstract INTRODUCTION Immune effector cell associated neurotoxicity (ICANS) and cytokine release syndrome (CRS) are potentially life-threatening complications with immune (IEC) therapies. We characterize ICANS in pediatric adult young adolescent (AYA) patients receiving IEC therapy at our institution. METHODS reviewed clinical characteristics severity (based on ASTCT Consensus Criteria) AYA who received products from 2018–2019 MDACC. RESULTS Nine patients, median age 15.5 (range: 3–25) years...
Intermediate‐conductance KCa3.1 and small‐conductance KCa2.3 channels are co‐expressed in vascular endothelium, where both contribute to endothelium‐derived hyperpolarization (EDH) vasodilator responses. However, despite having very similar biophysical properties, seem play different roles EDH. While predominantly localized endothelial cell projections activated by Ca 2+ released from the ER, co‐localize with TRP have been shown be involved sheer‐stress induced vasodilation. It therefore is...