A5052965972- Acute Myeloid Leukemia Research
- Genetic and phenotypic traits in livestock
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Meat and Animal Product Quality
- Synthesis and biological activity
- Retinoids in leukemia and cellular processes
- Blood disorders and treatments
- Plant Taxonomy and Phylogenetics
- Animal Behavior and Welfare Studies
- TGF-β signaling in diseases
- Immune cells in cancer
- Immune Response and Inflammation
- Cervical Cancer and HPV Research
- Inflammasome and immune disorders
- Protein Degradation and Inhibitors
- Cleft Lip and Palate Research
- Rabbits: Nutrition, Reproduction, Health
- Chronic Myeloid Leukemia Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Head and Neck Cancer Studies
- Acute Lymphoblastic Leukemia research
Albert Einstein College of Medicine
2019-2024
Sidney Kimmel Comprehensive Cancer Center
2023
Johns Hopkins University
2023
The University of Texas MD Anderson Cancer Center
2023
Montefiore Medical Center
2019-2021
University of Puerto Rico at Río Piedras
2016
Institut National de la Recherche Agronomique
2006-2011
Département Biologie et Amélioration des Plantes
2010
University of Puerto Rico System
2010
Abstract The BCL2-inhibitor, Venetoclax (VEN), has shown significant anti-leukemic efficacy in combination with the DNMT-inhibitor, Azacytidine (AZA). To explore mechanisms underlying selective sensitivity of mutant leukemia cells to VEN and AZA, we used cell-based isogenic models containing a common leukemia-associated mutation epigenetic regulator ASXL1 . KBM5 CRISPR/Cas9-mediated correction G710X showed reduced leukemic growth, increased myeloid differentiation, decreased HOXA BCL2 gene...
Summary Although the European rabbit ( Oryctolagus cuniculus ) is used both in agronomics and research, genomic resources for this species are still limited no microsatellite‐based genetic map has been reported. Our aim was to construct a with cytogenetically mapped microsatellites so as build an integrated cytogenetic map. A reference population of 187 rabbits comprising eight three‐generation families 10–25 offspring per family produced. One hundred ninety‐four 305 previously identified...
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy that continues to have poor prognosis despite recent therapeutic advances. Venetoclax (Ven), a BCL2-inhibitor has shown high response rate in AML; however, relapse invariable due mitochondrial dysregulation includes upregulation of the antiapoptotic protein MCL1, central mechanism Ven resistance (Ven-res). We previously demonstrated transcription factor STAT3 upregulated AML hematopoietic stem and progenitor cells (HSPCs)...
HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). has been established as risk factor for OPSCC, but infection may also reside in larynx and oral cavity. We evaluated status on OS Head Neck Squamous Cell Carcinoma (HNSCC) patients.HPV-16 was confirmed by amplification E6 E7 viral oncogenes through PCR assay IHC 185 HNSCC samples. Associations between clinicopathological parameters were performed using Fisher's exact test x(2). Survival analysis...
Overactivation of the Transforming Growth Factor Beta (TGF-β) pathway is implicated in pathogenesis cytopenias Myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML). IOA-359 IOA-360 are potent small molecule inhibitors TGF-beta Receptor type I kinase (TGF-βRI, also referred to as ALK5, activin receptor-like 5) that abrogate SMAD phosphorylation hematopoietic cell lines. Both were able inhibit TGF-β mediated gene transcription at specific doses. ALK5 abrogated growth inhibitory...
Abstract Gene polymorphism has been found to be associated with the susceptibility cancer or its severity as exemplified in CDKN2A gene. regulates G1 arrest and plays an important role head neck (HNSCC) carcinogenesis. Deregulated tumor expression of previously described association HNSCC clinical progression. Aberrant methylation is common gene silencing mechanism HNSCC. polymorphic, variant alleles G/A442, C/T 540, C/G 500 cancer. Previously we have shown that Puerto Rican population G/A...