A5047216250- Schizophrenia research and treatment
- Suicide and Self-Harm Studies
- Posttraumatic Stress Disorder Research
- Mental Health Treatment and Access
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Occupational Health and Performance
- Tryptophan and brain disorders
- Smoking Behavior and Cessation
- Agriculture and Farm Safety
- School Health and Nursing Education
- Mental Health and Psychiatry
- Treatment of Major Depression
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Functional Brain Connectivity Studies
- Resilience and Mental Health
- Chronic Disease Management Strategies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychosomatic Disorders and Their Treatments
- Migration, Health and Trauma
- Psychiatric care and mental health services
- Bipolar Disorder and Treatment
- Obsessive-Compulsive Spectrum Disorders
- Diet and metabolism studies
Walter Reed Army Institute of Research
2017-2024
Augusta University
2023
University of Georgia
2023
Johns Hopkins University
2011-2018
Clinical Research Management
2017
University of Maryland, Baltimore
2012-2016
Lancaster Bible College
2016
Geriatric Research Education and Clinical Center
2016
University of North Carolina at Chapel Hill
2015
William Carey University
2015
Objective This study assessed the association of perceptions traumatic experiences during psychiatric hospitalizations and treatment participation. Methods Participants (N=395) in Suffolk County Mental Health Project, who had been admitted for first time a psychotic disorder ten years earlier, were interviewed. The authors examined associations perceived trauma distressing or coercive past with patient characteristics Results Sixty-nine percent participants reported trauma. Perceived was...
Several lines of evidence have linked the endogenous neuromodulator kynurenic acid (KYNA) to schizophrenia. The pathophysiology schizophrenia is commonly associated with stress, and stress plays a key regulatory role in first, rate-limiting step kynurenine pathway, which produces KYNA.To determine whether level KYNA changes following psychological this change stress-related behavior.The was measured saliva samples taken at baseline 2 times laboratory-based challenge 128 participants (64...
Depression and negative symptoms can be difficult to distinguish in schizophrenia. Assessments for usually account the longitudinal nature of these symptoms, whereas instruments available measure depression mainly assess current or recent symptoms. This construct difference may confound comparison depressive schizophrenia because both domains have trait-like aspects. We developed an instrument "trait" as well "state" tested this (Maryland Trait State [MTSD] scale) a sample 98 individuals...
Background: Social network size and strength is an important determinant of overall health. Aims: This study describes the extent social among a sample individuals with serious mental illness (SMI) explores relationship between individual’s their experience internal stigma recovery attitudes. Methods: Over 2-year period, consecutive new patients SMI attending two community health clinics were recruited interviewed using comprehensive battery assessments including assessment internalized...
Objectives Although acute hypothalamic-pituitary-adrenal axis response to stress is often adaptive, prolonged responses may have detrimental effects. Many components of white matter structures are sensitive cortisol exposure. We aimed identify a behavioral laboratory assay for related brain pathophysiology in schizophrenia. hypothesized that an abnormally be linked abnormal integrity patients with Methods Acute and salivary was measured outside the scanner at pretest then 0, 20, 40 minutes...
Reduced speed of cerebral information processing is a cognitive deficit associated with schizophrenia. Normal (PS) requires intact white matter (WM) physiology to support transfer. In cohort 107 subjects (47/60 patients/controls), we demonstrate that PS deficits in schizophrenia patients are explained by reduced WM integrity, which measured using diffusion tensor imaging, mediated the mismatch WM/gray blood perfusion, and arterial spin labeling. Our findings specific PS, testing this...
Objective The study compared delays in seeking general medical care among adults with serious mental illness and a population sample. Associations of health status use emergency department services individuals were also assessed. Methods Data for 271 persons (clinic sample) 40,016 participants the National Health Interview Survey (NHIS compared. Results Fifty-three percent clinic sample 13% NHIS reported delays, most because difficulties accessing services. In sample, associated receipt...
The aim of this study was to examine whether there an association between tardive dyskinesia (TD) and number functional CYP2D6 genes.A Caucasian sample 70 patients recruited in 1996-1997 from South London Maudsley National Health Service (NHS) Foundation Trust, UK. Subjects had a DSM-IIIR diagnosis schizophrenia were treated with typical antipsychotics at doses equivalent least 100 mg chlorpromazine daily for 12 months prior assessment. All genotyped alleles*3-5, *41, amplifications the...
Abstract Introduction Diffusion weighted imaging (DWI) methods can noninvasively ascertain cerebral microstructure by examining pattern and directions of water diffusion in the brain. We calculated heritability for DWI parameters white (WM) gray matter (GM) to study genetic contribution signals across tissue boundaries. Methods Using Old Order Amish (OOA) population isolate with large family pedigrees high environmental homogeneity, we compared measures derived from three representative...
Abstract Aim The aim of the current study was to investigate psychometric properties BASC ‐2 (Behavior Assessment System for Children, Second Edition) Atypicality subscale in a sample adolescents receiving mental health services. Methods A large ( n = 1916) aged 12–20 years (median 14.7 years) completed ‐2. parent and teacher also measure each child. We analyzed internal consistency interrater reliabilities subscale, as well Depression Hyperactivity subscales comparison. Further analyses...
Tobacco use is a complex behavior. The Old Order Amish community offers unique advantages for the study of tobacco because homogenous ancestral background, sociocultural similarity, sex-specific social norms regarding use, and large family size. in almost exclusively confined to males. We examined characteristics familial aggregation among 1,216 males from cross-sectional prospectively collected data. Outcomes included ever using regularly, current quantity duration frequency use. Sixteen...
Objective: The study explored the association of delays in seeking general medical care with elevated blood pressure and metabolic abnormalities among individuals serious mental illness. Methods: Association pressure, serum hemoglobin A1c (HbA1C), lipids was assessed patients at two inner-city community health centers. Results: Of 271 participants, 62% reported due to attitudinal financial barriers. Care delay associated measured (adjusted odds ratio [AOR]=2.14, p=.029) HbA1c (AOR=3.18,...
Background: This study examined the prevalence and correlates of schizophrenia spectrum disorders (SSD) among a national sample 9006 children. Methods: Clinician‐assigned diagnoses were used to divide into two groups: children with SSD other Axis I disorders. Results: Three percent had diagnosis. African American (OR=1.71, 95% CI: 1.11, 2.65) Hispanic race/ethnicity (OR=1.96, 1.31, 2.94), greater number comorbid psychiatric (three diagnoses, OR=2.22, 1.49, 3.31), history attempting suicide...
ABSTRACT Introduction It is expected that future multi-domain operational (MDO) combat environments will be characterized by limited capabilities for immediate stress control support services soldiers or evacuation from theater. The requirements of the battlefield make it unlikely current models behavioral health (BH) treatment could implemented without significant adjustments. We conducted a qualitative study with Special Forces medics and operators who had deployed to austere conditions in...