A5067372729- Acute Lymphoblastic Leukemia research
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Adsorption and biosorption for pollutant removal
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Pregnancy and Medication Impact
- Adrenal Hormones and Disorders
- Metastasis and carcinoma case studies
- Vitamin D Research Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- IL-33, ST2, and ILC Pathways
- Extracellular vesicles in disease
- Renal Transplantation Outcomes and Treatments
- Thyroid Disorders and Treatments
- Anesthesia and Sedative Agents
- Adsorption, diffusion, and thermodynamic properties of materials
- Anodic Oxide Films and Nanostructures
- Immune cells in cancer
- IgG4-Related and Inflammatory Diseases
- Silicon Nanostructures and Photoluminescence
- Intraoperative Neuromonitoring and Anesthetic Effects
First Affiliated Hospital of Zhengzhou University
2012-2025
Foshan University
2020-2022
Zhengzhou University
2012-2022
Shanghai Maritime University
2021
The First Affiliated Hospital, Sun Yat-sen University
2010-2015
Sun Yat-sen University
2010-2015
Shaoguan Railway Hospital
2010
Abstract Gastric cancer (GC), notorious for its poor prognosis, often advances to peritoneal dissemination, a crucial determinant of detrimental outcomes. This study intricately explores the role TGFβ-Smad-LIF axis within tumor microenvironment in propagating metastasis, with specific emphasis on molecular mechanism instigating Neutrophil Extracellular Traps (NETs) formation and encouraging GC cellular functions. Through blend bioinformatics analyses, utilizing TCGA GEO databases, meticulous...
Cancer cell-derived extracellular vesicles (EVs) have extensive application in the formation of their environment, including metastasis. This study explored ability gastric cancer (GC) EVs-mediated microRNA-129-5p/E2F transcription factor 7/mitogen-activated protein kinase/extracellular regulated kinase (miR-129-5p/E2F7/MAPK/ERK) axis to affect peritoneal metastasis GC by delivering lncRNA small nucleolar RNA host gene 12 (SNHG12). EV-derived and SNHG12/miR-129-5p/E2F7 network were...
To evaluate the safety and effectiveness of novel long transparent cap-assisted clip closure technique in closing gastrointestinal defects. A retrospective analysis was performed on clinical data patients who underwent endoscopic resection for gastric submucosal tumors at First Affiliated Hospital Zhengzhou University from January 2020 to November 2023. Patients were categorized into Long Transparent Cap-Assisted Clip Closure group (LTCCC group) Purse-String Suture (PSS based method wound...
To investigate the potential influence of 5-aminosalicylic acid (5-ASA) on induction myelotoxicity during thiopurine therapy in inflammatory bowel disease patients.(a) The retrospective study included patients treated with azathioprine (AZA)/6-mercaptopurine (6-MP). Thiopurine methyltransferase (TPMT) activity and 6-thioguanine nucleotide (6-TGN) levels were detected at stable medication points. (b) prospective was performed active patients: 4 weeks AZA 50 mg/day followed by concomitant...
Unmasking the complex regulatory pathways that mediate malignant phenotypes of cancer cells can provide novel targets for therapies could limit recurrence and metastasis gastric (GC). Herein, we intended to clarify role embryonic ectoderm development protein (EED), microRNA-228-5p (miR-338-5p), methyltransferase like 3 (METTL3) CUB domain containing 1 (CDCP1) in GC. Differentially expressed miRNAs their target genes were extracted by silico analysis. The studies revealed high expression EED...
Not all of the adverse effects to thiopurine therapy can be explained by methyltransferase (TPMT) polymorphisms. This study was intended evaluate value TPMT genotype and phenotype measurement during first year therapy.Consecutive patients with inflammatory bowel disease (IBD) who were receiving azathioprine or 6-mercaptopurine followed up for 12 months. genotypes phenotypes examined in IBD before unrelated healthy volunteers polymerase chain reaction high-performance liquid chromatography.A...
Thiopurine drugs are widely used in the treatment of inflammatory bowel disease (IBD). The polymorphic enzyme thiopurine S-methyltransferase (TPMT) is importance for metabolism and adverse events occurrence. role other thiopurine-metabolizing enzymes less well known. This study investigated effects TPMT hypoxanthine guanine phosphoribosyltransferase (HPRT) activities on 6-thioguanine nucleotides (6-TGNs) concentrations thiopurine-induced leukopenia patients with IBD. Clinical data blood...
Background:Xilei-san is a traditional Chinese herbal medicine that has proven to be of possible use in the treatment ulcerative proctitis (UP) pilot study. Objectives: This study was intended compare Xilei-san with dexamethasone enemas subjects mild-to-moderate active UP. Methods: A double-blind randomized performed 35 subjects. During initial 8 weeks, received an enema or at bedtime, then discontinued and were followed for 12 weeks. All 3 g/day oral mesalazine during entire The disease...
Up to approximately 40% 50% of patients discontinue thiopurine therapy during the course inflammatory bowel disease (IBD). We investigated role metabolite in IBD treatment. This was a prospective study. receiving azathioprine (AZA) were prospectively included. Thiopurine methyltransferase (TPMT) genotypes examined before therapy, and levels at weeks 2, 4, 8, 12, 24, 48. In total, 132 The frequency leucopenia increased 6-thioguanine nucleotide (6-TGN) ≥420 pmol/8 × 108 RBC (odds ratio [OR] =...
Azathioprine (AZA) is a thiopurine prodrug which widely used in patients with inflammatory bowel disease (IBD). However, the use limited one-third of because adverse drug reactions (ADRs) or lack clinical response. It has been considered that polymorphic enzyme S-methyltransferase (TPMT) plays an important role vivo process AZA and occurrence its myelotoxicity. Glutathione S-transferase (GST) mutation another pharmacogenetic polymorphism probably involved metabolism tolerance. The aim this...
To assess the factors associated with progression of isolated terminal ileal lesions (ITILs) at colonoscopy in Chinese patients.Patients diagnosed ITILs were enrolled. The ileoscopy was performed by two experienced gastroenterologists every 52 weeks. A logistic regression analysis used to elucidate Crohn's disease (CD) and mucosal healing. log rank test differences cumulative proportion CD healing different groups times.(1) total 34 patients included no patient had taken nonsteroidal...
Ulcerative colitis is a chronic inflammatory bowel disorder, which having higher mortality rate. The present report evaluates the protective effect of miR-199a-3p oligomer for treatment (UC). was induced by administration dextran sulfate sodium [DSS (3%)] with drinking water duration one week in mice and treated same duration. Effect determined estimating body weight, blood stool length colon UC mice. Inflammatory cytokines, oxidative stress parameters Treg/Th17 ratio serum, intestinal...
In order to improve the recognition and tracking ability of fully-convolutional siamese networks for object in complex scenes, this paper proposes an improved algorithm with channel attention mechanism Mish activation function. First, is introduced into model, different weights are assigned each network’s representation ability. At same time, function used replace ReLU network. The smooth can make better information enter network, thereby obtaining accuracy generalization. Finally, gradient...
Abstract Background and study aims To assess the diagnostic value of contrast-enhanced endoscopic ultrasound (CE-EUS) for autoimmune pancreatitis other solid pancreatic masses. Patients methods A systematic search PubMed, Embase, Web Science was performed from inception to October 2022. We calculated individual pooled sensitivities specificities determine ability CE-EUS. In addition, we I2 test heterogeneity explored source by meta-regression analysis. Results total 472 patients seven...
A 61-year-old man with a 6-month history of recurrent hematochezia was admitted to our hospital for the management symptomatic anemia. Upon admission, his hemoglobin level 60 g/L. Esophagogastroduodenoscopy and colonoscopy were performed but did not reveal cause Subsequently, single-balloon enteroscopy (SBE) conducted, which identified an actively bleeding angioectasia in distal jejunum, approximately 300 cm from incisors ([Fig. 1] a, [Video 1]). Hemostasis achieved using argon plasma...
To evaluate whether abdominal compression significantly increased the total enteroscopy rate in single-balloon (SBE).Consecutive patients who underwent SBE at 2 hospitals were prospectively included between June 1, 2020, and September 30, 2021. They randomly divided into an group a non-abdominal with use of sealed envelopes generated by computer. Total rates compared groups.The study 200 patients. The 73% 16% groups, respectively (relative risk, 13.55; 95% CI, 6.79 to 27.00; P<.001). was...
Xanthine oxidase (XO) competes with thiopurine S-methyltransferase (TPMT) and hypoxanthine guanine phosphoribosyltransferase (HPRT) to metabolize azathioprine (AZA)/6-mercaptopurine (6-MP) in vivo. A retrospective investigation was performed detect the activity of XO curative Chinese inflammatory bowel disease (IBD) patients. We also evaluated whether a relationship between incidence thiopurine-induced adverse effects (AEs) existed. Clinical data blood samples were collected from 140 IBD...