A5083099452- Ion channel regulation and function
- Erythrocyte Function and Pathophysiology
- Drug Transport and Resistance Mechanisms
- Neuroscience and Neuropharmacology Research
- Ginger and Zingiberaceae research
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Effects of Natural Compounds
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Ion Transport and Channel Regulation
- Protein Kinase Regulation and GTPase Signaling
- Natural product bioactivities and synthesis
- Complementary and Alternative Medicine Studies
- Ion Channels and Receptors
- ATP Synthase and ATPases Research
- Natural Antidiabetic Agents Studies
- Ginseng Biological Effects and Applications
- Computational Drug Discovery Methods
- Cellular transport and secretion
- Adipose Tissue and Metabolism
- Enzyme function and inhibition
- Receptor Mechanisms and Signaling
- Cardiac electrophysiology and arrhythmias
- Lipid Membrane Structure and Behavior
- Pharmacological Effects and Toxicity Studies
The University of Sydney
2011-2024
Western Sydney University
2017-2024
Royal Prince Alfred Hospital
2007
Brigham and Women's Hospital
2005
Harvard University
2005
Sydney Hospital
2005
St George Hospital
2005
UNSW Sydney
2005
Institut de Biologie Physico-Chimique
1994
University of British Columbia
1982-1991
Aim The aim of this study was to investigate the effect St John's wort and ginseng on pharmacokinetics pharmacodynamics warfarin. Methods This an open‐label, three‐way crossover randomized in 12 healthy male subjects, who received a single 25‐mg dose warfarin alone or after 14 days’ pretreatment with wort, 7 ginseng. Dosing continued for days administration dose. Platelet aggregation, international normalized ratio (INR) prothrombin time, enantiomer protein binding, concentrations plasma...
The aim of this study was to investigate the effect two common herbal medicines, ginkgo and ginger, on pharmacokinetics pharmacodynamics warfarin independent these herbs clotting status.
Gingerols, the pungent constituents of ginger, were synthesized and assessed as agonists capsaicin‐activated VR1 (vanilloid) receptor. [6]‐Gingerol [8]‐gingerol evoked capsaicin‐like intracellular Ca 2+ transients ion currents in cultured DRG neurones. These effects gingerols blocked by capsazepine, receptor antagonist. The potency increased with increasing size side chain overall hydrophobicity series. We conclude that represent a novel class naturally occurring may contribute to medicinal...
Important mechanisms that regulate inhibitory and facilitatory effects on TRPV1-mediated nociception are desensitization phosphorylation, respectively. Using Ca2+-imaging, we have previously shown of TRPV1 upon successive capsaicin applications was reversed by protein kinase C activation in dorsal root ganglion neurons CHO cells. Here, using both Ca2+-imaging patch-clamp methods, show PMA-induced PKCepsilon is essential for increased sensitivity desensitized TRPV1. has two putative...
Metabolic syndrome, including obesity, dyslipidaemia, hyperglycaemia and insulin resistance that predisposes type 2 diabetes is a major disease problem around the world plethora of herbal medicines are claimed to be effective in controlling these disorders. The rhizome Zingiber officinale (Zingiberaceae) commonly used as spice various foods beverages. Apart from its other traditional medical uses, Z. has been control dyslipidaemia. In present study, protective effects an ethanolic extract on...
In this study we investigate the active constituents of rhizome <i>Zingiber officinale</i>, Roscoe (ginger) and determine their activity on glucose uptake in cultured L6 myotubes molecular mechanism underlying action. Freeze-dried ginger powder was extracted with ethyl acetate (1 kg/3 L) to give total extract, which then separated into seven fractions, consisting nonpolar moderately polar compounds, using a short-column vacuum chromatographic method. The most fraction (F7) further purified...
Excess triglyceride (TG) accumulation and increased fatty acid (FA) oxidation in the diabetic heart contribute to cardiac dysfunction. Punica granatum flower (PGF) is a traditional antidiabetic medicine. Here, we investigated effects mechanisms of action PGF extract on abnormal lipid metabolism both vivo vitro. Long-term oral administration (500 mg kg(-1)) reduced TG content, accompanied by decrease plasma levels total cholesterol Zucker (ZDF) rats, indicating improvement hyperlipidemia this...