A5044306881- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Respiratory viral infections research
- Eosinophilic Esophagitis
- Allergic Rhinitis and Sensitization
- Gut microbiota and health
- Complement system in diseases
- Family and Disability Support Research
- Tracheal and airway disorders
- Down syndrome and intellectual disability research
- Urticaria and Related Conditions
- Viral-associated cancers and disorders
- SARS-CoV-2 and COVID-19 Research
- Lymphoma Diagnosis and Treatment
- Dermatology and Skin Diseases
- Probiotics and Fermented Foods
- Blood disorders and treatments
- Parasites and Host Interactions
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Ethics and Legal Issues in Pediatric Healthcare
- Child Nutrition and Feeding Issues
- Pneumocystis jirovecii pneumonia detection and treatment
Louisiana State University Health Sciences Center New Orleans
2015-2025
Louisiana State University
2013-2025
Children's Hospital of New Orleans
2018-2024
University of New Orleans
2013-2023
State Street (United States)
2020
ENT and Allergy
2020
National Blood Authority
2017
Abstract Purpose The safety and tolerability of elapegademase (elapegademase-lvlr; Revcovi ® ) a PEGylated recombinant adenosine deaminase (ADA), were demonstrated in two Phase 3 clinical trials the U.S. Japan patients with ADA-deficient severe combined immunodeficiency (ADA-SCID). Elapegademase replaced Adagen (pegademase, bovine ADA) 2018. This registry study (NCT03878069) was conducted as post-marketing requirement to bolster limited effectiveness data on ADA-SCID starting enzyme...
Food protein-induced allergic proctocolitis (FPIAP) is a non-IgE-mediated condition that presents with hematochezia in otherwise healthy infants. It most commonly induced by cow's milk protein via breast or formula. The prognosis for FPIAP generally considered favorable infants achieving symptomatic resolution after diet modification. Most go on to tolerate the offending foods 1–3 years of age. Over 8 at our institution, five patients were identified and noted have during infancy subsequent...
An 8-year-old male from south Louisiana was diagnosed with Loeffler syndrome of suspected Ascaris origin. Further investigation the farm recovered larvated, infective eggs soil in drains surrounding pens on family's small hog farm. Molecular analysis eggs, conjunction Ascaris-specific IgE, inadequate management and sanitation, behavioral risk factors indicate patient had an suum soil-transmitted infection.
Löffler syndrome, a fulminant eosinophilic pneumonitis associated with the larval migratory phase of human parasites, is rarely reported in United States. A previously healthy 8-year-old male was hospitalized tachypnea, cough, hypoxemia, and fever one week's duration. History revealed exposure to pigs on his family's farm southernmost Louisiana, where patient responsible for cleaning farm's pigpens. His fingernails were soiled extremely short, edge nail bed exposed secondary onychophagia....
In this study, the authors characterize fecal microbiomes to identify bacterial taxa and their products that may influence expression of food allergies in children adults.Participants included a cohort 18 twin pairs across broad age range, 13 which were discordant (one sibling had allergy other was healthy) 5 concordant (both siblings allergy).First, samples collected from who lived same household, they equally avoided foods affected found be allergic. 16S ribosomal RNA gene amplicon...
To determine the influence of a variety environmental and demographic factors on development challenge-confirmed egg allergy in infants.The study included 5276 infants presenting for their 12-month immunizations Melbourne, Australia, with focus 453 confirmed by oral food challenge.At time initial testing, parents completed questionnaire regarding exposures factors. Infants underwent skin-prick testing (SPT) to regardless history reaction. positive SPT then additional including...
To characterize clinical and laboratory aspects of p40phox deficiency, a unique autosomal recessive form chronic granulomatous disease (CGD) previously described in only 1 patient.The population included 24 patients with deficiency from 12 families 8 countries. Both male female are reported, age ranging to 47 years.Clinical history each case was collected, including autoinflammatory manifestations infection history. Laboratory analysis both gene sequencing numerous functional studies the...
Although informatics can be used to identify damaging variants, in this study, all variants were evaluated experimental vitro systems define the detrimental impact of variant identified on type-I IFN system.Thus, each LOF found a patient was proven through what is known as functional genomics, revealing an irrefutable association between and biological relevance. CONCLUSIONS:The initial hypothesis investigators regarding severe COVID-19 potentially representing expression IEI, especially...
K Beyer, O Eckermann, S Hompes, L Grabenhenrich, M Worm. Allergy. 2012;67(11):1451–1456 To assess the incidence of anaphylactic reactions in Berlin area, as well elicitors, symptoms, and emergency treatment. Emergency physicians throughout area (an urban ∼4 million people) were asked to complete questionnaires. A questionnaire was used gather following information on anaphylaxis cases: gender, age, reaction site, outcome, eliciting factors, applied drugs. Forms completed prospectively by...