A5071904144- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Blood disorders and treatments
- Food Allergy and Anaphylaxis Research
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Child and Adolescent Psychosocial and Emotional Development
- Respiratory and Cough-Related Research
- T-cell and B-cell Immunology
- Platelet Disorders and Treatments
- Cystic Fibrosis Research Advances
- Allergic Rhinitis and Sensitization
- Cytomegalovirus and herpesvirus research
- Viral Infections and Immunology Research
- Obesity, Physical Activity, Diet
- Stress Responses and Cortisol
- Blood groups and transfusion
- Respiratory viral infections research
- Diabetes and associated disorders
- Chronic Lymphocytic Leukemia Research
- Child Nutrition and Feeding Issues
- Sinusitis and nasal conditions
- Birth, Development, and Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
University at Buffalo, State University of New York
2015-2025
Jacobs Institute
2017-2025
Women & Children's Hospital of Buffalo
2010-2022
Island Institute
2016-2021
Jacobs (United States)
2020-2021
Buffalo State University
2012-2015
Johns Hopkins University
2010
Washington State University Vancouver
2010
University of Washington
2005
University of Minnesota
1992
Newborn screening for severe combined immunodeficiency (SCID) using assays to detect T-cell receptor excision circles (TRECs) began in Wisconsin 2008, and SCID was added the national recommended uniform panel newborn screened disorders 2010. Currently 23 states, District of Columbia, Navajo Nation conduct population-wide SCID. The incidence is estimated at 1 100,000 births.To present data from a spectrum programs, establish population-based other conditions with lymphopenia, document early...
Secondary hypogammaglobulinemia (SHG) is characterized by reduced immunoglobulin levels due to acquired causes of decreased antibody production or increased loss. Clarification regarding whether the secondary primary important because this has implications for evaluation and management. Prior receipt immunosuppressive medications and/or presence conditions associated with SHG development, including protein loss syndromes, are histories that raise suspicion SHG. In patients these histories, a...
The present objective was to estimate the association between childhood blood lead concentrations (BLC) and clinical diagnoses of influenza or pneumonia among a large, low-income, underrepresented cohort children using retrospective design. Medical records were pulled from Temple University Hospital System (TUHS) located in inner-city Philadelphia, PA 2010 2020. All ≤14 years age with an available value their medical included analysis (N = 14,217). Lead exposure measured via BLC as reported...
Abstract Purpose The safety and tolerability of elapegademase (elapegademase-lvlr; Revcovi ® ) a PEGylated recombinant adenosine deaminase (ADA), were demonstrated in two Phase 3 clinical trials the U.S. Japan patients with ADA-deficient severe combined immunodeficiency (ADA-SCID). Elapegademase replaced Adagen (pegademase, bovine ADA) 2018. This registry study (NCT03878069) was conducted as post-marketing requirement to bolster limited effectiveness data on ADA-SCID starting enzyme...
Metabolic detoxification with enzyme replacement therapy (ERT) promotes immune recovery in patients adenosine deaminase (ADA)-deficient severe combined immunodeficiency (ADA-SCID). Elapegademase is a PEGylated recombinant bovine ADA ERT developed to replace the now-discontinued bovine-derived pegademase. This study was 1-way crossover from pegademase elapegademase 7 ADA-SCID assess efficacy and safety outcomes for elapegademase.After once-weekly dosage adjusted achieve therapeutic metabolic...
Abstract Background The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, whether attenuates infection severity IEI. Objective To estimate examine effect on outcomes Methods We built a secure registry database conjunction the US Immunodeficiency Network to frequency indicators effectiveness IEI patients. opened January 1, 2022, closed August 19, 2022. Results Physicians entered data 1245 from 24...
Abstract The effect of a positive first‐time experience on adrenocortical activity was examined in 48 6‐ to 13‐month‐old infants who took part two sessions YMCA‐like mother–infant swim class. Experience manipulated by comparing Novice swimmers with previously had taken class, and examining responses first versus second class session. In addition, the effects temperamental fear novelty were maternal report prior Preswim Postswim cortisol levels compared measures obtained at same time day...