A5101771690- Cytomegalovirus and herpesvirus research
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- CAR-T cell therapy research
- Hematological disorders and diagnostics
- Ocular Infections and Treatments
- HIV-related health complications and treatments
- Virus-based gene therapy research
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Surgical site infection prevention
- Musculoskeletal synovial abnormalities and treatments
- Wound Healing and Treatments
- Adenosine and Purinergic Signaling
- Bone health and treatments
Université de Montréal
2022-2023
Monash University
2018
Monash Health
2018
Peninsula Health
2018
Saint Joseph University
2004
Metabolic detoxification with enzyme replacement therapy (ERT) promotes immune recovery in patients adenosine deaminase (ADA)-deficient severe combined immunodeficiency (ADA-SCID). Elapegademase is a PEGylated recombinant bovine ADA ERT developed to replace the now-discontinued bovine-derived pegademase. This study was 1-way crossover from pegademase elapegademase 7 ADA-SCID assess efficacy and safety outcomes for elapegademase.After once-weekly dosage adjusted achieve therapeutic metabolic...
Background EXTL3 deficiency is associated with a neuro-immuno-skeletal dysplasia syndrome due to defective heparan sulfate synthesis. Patients can present SCID phenotype from inability generate early T cell progenitors in the bone marrow and impaired thymopoiesis thymic epithelial differentiation. There are limited data on success of allogeneic hematopoietic stem transplantation (HSCT) patients deficiency. We hypothesized that HSCT restore naïve immune reconstitution despite thymopoiesis....