A5103157594- Acute Kidney Injury Research
- Liver Disease and Transplantation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Engineering Education and Pedagogy
- Immunodeficiency and Autoimmune Disorders
- Mechanical Circulatory Support Devices
- Innovations in Medical Education
- Cardiac Valve Diseases and Treatments
- Cardiac Ischemia and Reperfusion
- Organ Transplantation Techniques and Outcomes
- Engineering Education and Curriculum Development
- Career Development and Diversity
- Hemoglobinopathies and Related Disorders
- Kruppel-like factors research
- Biological Research and Disease Studies
- Learning Styles and Cognitive Differences
- Social Media in Health Education
- Renal Transplantation Outcomes and Treatments
- Cardiac Fibrosis and Remodeling
- Tuberous Sclerosis Complex Research
- Erythrocyte Function and Pathophysiology
- Electrolyte and hormonal disorders
- Nutrition and Health in Aging
- Muscle and Compartmental Disorders
- Allergic Rhinitis and Sensitization
University of Missouri–Kansas City
2024
Mercy Hospital
2023
Children's Mercy Hospital
2022
Indiana University – Purdue University Indianapolis
2001-2021
Indiana University School of Medicine
2019-2021
University of Leeds
1966-2017
University of Arizona
2003-2008
MedStar Franklin Square Medical Center
2005
VA Puget Sound Health Care System
2003
University of Washington
2003
In the rat, p53 promotes tubular apoptosis after ischemic AKI. Acute pharmacologic inhibition of is protective in this setting, but chronic enhances fibrosis, demonstrating that role AKI incompletely understood. Here, we investigated whether genetic absence also Surprisingly, p53-knockout mice (p53(-/-)) had worse kidney injury, compared with wild-type mice, and exhibited increased prolonged infiltration leukocytes ischemia. pifithrin-α mimicked observations p53(-/-) mice. Chimeric lacked...
This study was undertaken to determine if insulin resistance without and with obesity influences LDL response dietary cholesterol saturated fat.We fed 0, 2, 4 egg yolks per day 197 healthy subjects in a 4-week, double-blind, randomized, crossover design. Subjects were dichotomized on body mass index (<27.5 > or =27.5 kg/m2) sensitivity (insulin-sensitivity =4.2x1.0(-4) <4.2x1.0(-4) min(-1) microU/mL), yielding insulin-sensitive (IS, n=65), insulin-resistant (IR, n=75), obese (OIR, n=58)...
OBJECTIVES: Acute kidney injury (AKI) is a common complication in hospitalized patients with cirrhosis which contributes to morbidity and mortality. Improved prediction of AKI this population needed for prevention early intervention. We developed model identify at risk AKI. METHODS: Admission data from prospective cohort without on admission (n = 397) was used derivation. development the first week captured. Independent predictors multivariate logistic regression were develop model. External...
INTRODUCTION: In patients with cirrhosis, differences between acute kidney injury (AKI) at the time of hospital admission (community-acquired) and AKI occurring during hospitalization (hospital-acquired) have not been explored. We aimed to compare hospital-acquired (H-AKI) community-acquired (C-AKI) in a large, prospective study. METHODS: Hospitalized cirrhosis were enrolled (N = 519) followed for 90 days after discharge mortality. The primary outcome was mortality within days; secondary...
Abstract Background The CDC and ACIP recommend COVID-19 vaccination for patients with inborn errors of immunity (IEI). Not much is known about vaccine safety in IEI, whether attenuates infection severity IEI. Objective To estimate examine effect on outcomes Methods We built a secure registry database conjunction the US Immunodeficiency Network to frequency indicators effectiveness IEI patients. opened January 1, 2022, closed August 19, 2022. Results Physicians entered data 1245 from 24...
Background and Purpose —MRI is more sensitive than CT, but the significance of brain abnormalities seen on MR images obtained in older subjects with transient ischemic attack (TIA) not clear. We studied prevalence risk factors associated MRI-demonstrated infarcts elderly a history TIA. Methods —Participants Cardiovascular Health Study, aged 65 years or without prior stroke, were MRI (n=3456). The (≥3 mm) was determined cardiovascular clinical subclinical disease Results —Subjects TIA (n=100)...
Acute kidney injury (AKI) is a common complication in hospitalized patients with cirrhosis. Uromodulin, protein uniquely produced by the and released both urine circulation, has been shown to regulate AKI linked tubular reserve. Although low levels of uromodulin are associated after cardiac surgery, it unclear whether circulating can stratify risk AKI, particularly susceptible population such as Thus, we investigated plasma measured at time admission subsequent hospital-acquired (defined...
Karnofsky performance status (KPS), a measure of physical frailty, predicts pre-transplant and post-transplant outcomes in liver transplantation, but has not been assessed simultaneous liver-kidney transplantation (SLKT). We examined the association between KPS SLKT waitlist registrants recipients (2005-2018) UNOS database. was categorized into A (able to work), B provide self-care), C (unable self-care). Cox regression competing risk analysis were used assess groups outcomes. total 10,785...
Isoproterenol (Iso) was a clinical therapeutic that is now used as research means for the induction of cardiac hypertrophy. Currently, dobutamine (Dob) has replaced Iso preferred inotropic β-adrenergic agent to wean patients from cardiopulmonary bypass and sustain adequate function during postoperative period. We sought compare structural functional effects long-term administration (7days) with Dob at dose 40μg/mouse/day in 12-week-old C57BL/6 female mice. Cardiac determined transthoracic...
Guidelines recommend albumin as the plasma-expander of choice for acute kidney injury (AKI) in cirrhosis. However, impact these recommendations on patient outcomes remains unclear. We aimed to determine practice-patterns and associated with use a large, nationwide-US cohort hospitalized cirrhotics AKI.A retrospective study was performed AKI using Cerner-Health-Facts database from January 2009 March 2018. 6786 were included analysis albumin-practice-patterns, 4126 had available data....
Purpose: To understand clinicians' perspectives on dialysis care of undocumented immigrants. Methods: A 21-item Internet-based survey using Survey Monkey® was sent to 765 physicians and nurses at a safety-net hospital located in Indianapolis, IN. Moral distress thermometer score used assess moral (MD). Participants were asked rate their MD regarding five ethically challenging clinical situations: (1) frail patients with multiple comorbidities poor quality life, (2) dementia, (3) noncompliant...
Clenbuterol has recently been shown to reverse pathologic cardiac remodeling during left ventricular assist device (LVAD) support, leading restored function and explantation of LVAD devices. However, others have not able support these observations. Our hypothesis is that the beta(2)-adrenergic activity clenbuterol induces extracellular matrix (ECM) remodeling, resulting in increased interstitial fibrillar collagen content altered diastolic may account for conflicting reports. The intent this...
The author focuses on graduate career change women and the type of who are willing to try make difficult transition engineering able succeed. source their lack encouragement enter is examined. woman engineer compared with traditional US male in general characteristics. Lastly, preferred learning styles also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Multivalvular endocarditis of native cardiac valves due to streptococci in patients without any predisposing conditions has not been reported previously. Moreover, the effect exposure systemic steroids on outcome subacute bacterial (SBE) is well known. We describe 2 with SBE involving 3 valves, who were initially exposed steroid therapy under clinical impression 'rheumatologic disorders'.
A study was conducted that analyzed the relationship between various characteristics of preclinical curriculum and institutional performance on Part I examination National Board Medical Examiners (NBME) at a sample 85 U.S. medical schools. Total scheduled hours per week single characteristic having positive significant with NBME performance. However, when data were controlled by school selectivity in admissions policy taking examination, total failed to make contribution prediction The...
Some methods of the Cooper Union 1989 National Survey Women Engineers are presented. This survey, with 2077 respondents (a 52% survey return), included demographics working woman engineer, a career profile, gender issues in work place (including job satisfaction), personal and marriage family issues. The was used by permission on graduates Graduate Career Change Program (GCCP) Industrial Engineering at Arizona State University (ASU). A comparison these change women engineers surveyed...