A5062255961- Fungal and yeast genetics research
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Microtubule and mitosis dynamics
- Chromosomal and Genetic Variations
- Microbial Metabolic Engineering and Bioproduction
- Cytokine Signaling Pathways and Interactions
- Fermentation and Sensory Analysis
- Antifungal resistance and susceptibility
- DNA Repair Mechanisms
- RNA modifications and cancer
- RNA regulation and disease
- Metabolism and Genetic Disorders
- Yeasts and Rust Fungi Studies
- Polyamine Metabolism and Applications
- Genomic variations and chromosomal abnormalities
- interferon and immune responses
The University of Texas Southwestern Medical Center
2007-2017
Southwestern Medical Center
2010
Comenius University Bratislava
2002-2005
UCLouvain
2002-2003
Mitochondrial DNA is organized as a nucleoprotein complex called the nucleoid. Its major protein components have been identified in different organisms, but it yet unknown whether nucleoids undergo any form of remodeling. Using an organello ChIP-on-chip assay, we demonstrate that DNA-bending Abf2 binds to most mitochondrial genome with preference for GC-rich gene sequences. Thus, bona fide DNA-packaging vivo. Nucleoids more open structure under respiring growth conditions which ratio...
Little is known about the regulation of ion transport across inner mitochondrial membrane in Saccharomyces cerevisiae. To approach this problem, we devised a screening procedure for facilitating identification proteins involved homeostasis. Taking advantage growth inhibition yeast cells by electroneutral K(+)/H(+) ionophore nigericin, screened genetic mutations that would render tolerant to drug when grown on nonfermentable carbon source and identified several candidate genes including...
Eukaryotic genomes are organized into chromosomes. In order to maintain genomic stability during cell proliferation, a series of elaborate processes is employed ensure that chromosomes duplicated and segregated equally daughter cells. Sister chromatid cohesion, tight association sister chromatids, allows their attachment the opposite centrosomes. cohesion depends on cohesin complex, proteinaceous ring entraps chromatids together. At metaphase-to-anaphase transition, protease called separase...