Khaled Mukaddam

ORCID: 0000-0001-9137-1664
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About
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Research Areas
  • Dental Implant Techniques and Outcomes
  • Bone Tissue Engineering Materials
  • Dental Radiography and Imaging
  • Dental materials and restorations
  • Periodontal Regeneration and Treatments
  • Orthodontics and Dentofacial Orthopedics
  • Medical and Biological Ozone Research
  • Endodontics and Root Canal Treatments
  • Otolaryngology and Infectious Diseases
  • Travel-related health issues
  • Additive Manufacturing and 3D Printing Technologies
  • Fusion materials and technologies
  • Sinusitis and nasal conditions
  • Diabetes and associated disorders
  • Cytokine Signaling Pathways and Interactions
  • Bone Metabolism and Diseases
  • Mycobacterium research and diagnosis
  • Anatomy and Medical Technology
  • Oral and Maxillofacial Pathology
  • Dental Trauma and Treatments
  • Diabetes Treatment and Management
  • Oral and gingival health research
  • Sports injuries and prevention
  • Infrared Thermography in Medicine
  • 3D Printing in Biomedical Research

University of Basel
2014-2025

Medical University of Graz
2022-2023

Semmelweis University
2022

Universitäres Zentrum für Zahnmedizin Basel
2014-2020

Background: 3D printing is a rapidly developing technology in the healthcare industry and dentistry. Its application clearly shows that this area of digital dentistry has potential for everyday usage across all fields, including prosthodontics, orthodontics, maxillofacial surgery, oral implantology. However, despite gaining ground, there lack information about how specialists (dentists dental technicians) use additive technology. Our research group aimed to investigate impact social media on...

10.3390/ijerph19041921 article EN International Journal of Environmental Research and Public Health 2022-02-09

Abstract Objectives To compare the deviation of different systems for Guided Implant Surgery (GIS) related to specific tolerance between drills and sleeves. Material methods Four GIS their appropriate sleeves were used: Camlog Guide (CG), Straumann (SG), SIC (SIG), NobelGuide (NG). System‐appropriate metal inserted into plexiglass boxes, guided drilling procedure was performed (i) holding in most centric position (ii) applying forces eccentrically. Digital microscope images boxes taken axial...

10.1111/clr.12930 article EN Clinical Oral Implants Research 2016-07-27

Abstract Objectives The aim of this in vitro study was to compare the heat generation during guided osteotomy preparation (GOP) with that a conventional approach (CA) for single and sequential drilling protocol. Methods Temperature measurements were performed standardized preparations polyurethane foam blocks an infrared camera. four groups included without use surgical guide. In first group (single CA) second GOP), only final drills diameters applied once. third (sequential fourth two...

10.1111/clr.13398 article EN Clinical Oral Implants Research 2018-12-22

Dental implant therapy is a widely used clinical procedure for restoring missing teeth in patients. Zirconia implants were introduced as an alternative to titanium due their excellent biocompatibility and esthetic properties. The nuclear factor kappa B (NF-κB) signalling pathway responsible multiple aspects of innate adaptive immune functions serves significant crucial mediator inflammatory processes. dysregulation NF-κB activation induces pathological processes diseases. purpose this study...

10.3390/ma18040884 article EN Materials 2025-02-18

The aim of this study was to assess the antibacterial efficacy nanostructured dental implant surfaces against Porphyromonas gingivalis, a crucial bacterium in progression peri-implantitis. Additionally, evaluate possible effect modified surface on viability human gingival fibroblasts (HGnFs). As detailed prior research, helium ions sputtering used produce nanospiked titanium with height 1000 nm (Ti1000). Smooth machined (Ti machined) and SLA disks (TiSLA) served as controls. characteristics...

10.3290/j.qi.b5993849 article EN PubMed 2025-02-24

Abstract Introduction Since antimicrobial resistance, caused by various factors including antibiotic overuse and abuse, is a severe challenge, the necessity of perioperative prophylactic for surgical third molar removal remains contentious topic. This study determined whether prophylaxis can reduce site infections (SSIs), swelling, pain in case wisdom teeth. Material methods A randomized, double-blind, placebo-controlled clinical trial with split-mouth design. medication 2 g amoxicillin,...

10.1007/s00784-022-04597-5 article EN cc-by Clinical Oral Investigations 2022-07-06

Objectives: The transgingival part of titanium implants is either machined or polished. Cell-surface interactions as a result nano-modified surfaces could help gingival fibroblast adhesion and support antibacterial properties by means the physico-mechanical aspects surfaces. aim present study was to determine how nanocavity surface affects viability human fibroblasts (HGF-1). Additionally, its against Porphyromonas gingivalis were tested. Material Methods: Two different specimens evaluated:...

10.3390/ma14247686 article EN Materials 2021-12-13

Nano-modified surfaces for dental implants may improve gingival fibroblast adhesion and antibacterial characteristics through cell-surface interactions. The present study investigated how a nanocavity titanium surface impacts the viability of human fibroblasts (HGF-1) compared its response to Porphyromonas gingivalis with those marketed implant surfaces.Commercial zirconia disks, namely, sandblasted acid-etched (SLA), (ZLA), polished (PT) (ZrP), nanostructured disks (NTDs) were tested....

10.1007/s00784-023-05235-4 article EN cc-by Clinical Oral Investigations 2023-08-31

The aim of the study was to fabricate a nanospike surface on titanium alloy using newly established method low-energy helium ion bombardment. Various methods achieve formation have been introduced recently, and their antibacterial properties mainly investigated with respect Escherichia coli Staphylococcus aureus. Oral pathogens such as Porphyromonas gingivalis play an important role in development peri-implantitis. For that reason, novel, nanostructured against P. were assessed, possible...

10.3390/nano12071065 article EN cc-by Nanomaterials 2022-03-24

The purpose of this study was to evaluate whether fully digitally guided implant surgery may be performed with sufficient accuracy based on printing virtually designed templates after matching a surface scan the magnetic resonance imaging (MRI) dataset mimicking edentulous cases cadaver maxillae pigs.The palatal mucosa five young pig cadavers scanned an intraoral scanner. High-resolution MRI jaws performed, and images were exported as DICOM files uploaded into software for planning. Six...

10.11607/jomi.7076 article EN The International Journal of Oral & Maxillofacial Implants 2019-03-01

Background: Diabetes is a well-known predisposing factor for oral diseases, so prevention in an early age mandatory. Objective: To provide screening children living with type 1 diabetes. We aimed to investigate the and general health indexes of T1DM compare these data healthy siblings controls. Methods: In this cross-sectional study, 120 DM patients 78 siblings, thereafter 80 95 controls, took part. A detailed questionnaire, panoramic radiographs, lateral cephalograms were obtained every...

10.3390/ijerph19010545 article EN International Journal of Environmental Research and Public Health 2022-01-04

The aim of this prospective case series was to evaluate single-piece zirconia implants restored with lithium disilicate CAD/CAM crowns through a long-term follow-up.In trial, 20 one-piece were placed in patients. Implants (i) immediately provisionals, and (ii) permanently four months after surgery. Patients followed for 11 years. Clinical parameters radiological measurements the assessed. For statistical analysis, paired t-test applied.Four counted as implant failure due loss stability,...

10.3390/ma14226738 article EN Materials 2021-11-09

Abstract Objectives To compare the stability of a screw‐retained connection in novel two‐piece zirconia implant to conventional titanium‐based an vitro chewing simulation including artificial ageing. Material and methods Incisor (I) molar (M) shaped monolithic crowns were on either (test) or titanium (control) implants resulting 4 groups 8 samples (titanium with incisor‐shaped (T‐I), molar‐shaped (T‐M), (Z‐I) (Z‐M). These subjected ageing by thermal cycling (TC: 2 × 3000 5°C/55°C cycles min)...

10.1111/clr.13597 article EN Clinical Oral Implants Research 2020-03-17

Abstract This study investigates nanostructured titanium surfaces (Ti2 spikes) that promote the viability of osteoblasts and fibroblasts prevent bacterial colonisation. Helium ion irradiation was adopted to produce nanometric‐sized cones on titanium. Human (hFOB) human gingiva (hGF) were used for analysis. A a cytotoxicity assay conducted evaluate lactate dehydrogenase (LDH) activity assess cell damage in Ti2 spikes compared discs with sandblasted acid‐etched SLA) surface. The antibacterial...

10.1002/jbm.a.37768 article EN cc-by-nc Journal of Biomedical Materials Research Part A 2024-06-24

The aim of this study was to evaluate functional and esthetic clinical outcomes patient satisfaction with narrow-diameter implants in comparison standard-diameter the anterior zone maxilla a follow-up examination after 1 6 years.The designed as retrospective cohort investigation including 27 patients receiving 3.3-mm diameter single implant (NDI, n = 14) or 4.1-mm (SDI, 16). Descriptive analytical statistics were performed comparing both groups regard outcome, sulcus fluid flow-rate, crown...

10.3290/j.qi.b2887673 article EN PubMed 2022-05-11

Michael Kuster/Khaled Mukaddam, DMD/Nicola U. Zitzmann, DMD, PhD/Andreas Filippi, DMD/Sebastian Kühl, DMD: Purpose: The aim of this in vitro study was to evaluate the temperature development a novel, electropolished drill design during conventional and guided implant osteotomy comparison drills under standardized conditions. Materials Methods: Single sequential 12-mm-deep drilling protocols (guided unguided) with (control groups) novel (test were performed artificial bone blocks external...

10.11607/jomi.8583 article EN The International Journal of Oral & Maxillofacial Implants 2021-05-01

Simultaneous avulsion of four or more teeth is a rare event. This case report examines the dental care given to an adult who, during bicycle accident, experienced mandibular incisor as well all his maxillary incisors. In immediate aftermath out five incisors were located, promptly collected, and stored in tooth rescue box, within 20-min window. Replantation splinting performed on day accident. Endodontic treatment involved sequential intracanal dressing with antibiotic-corticosteroid paste...

10.1111/edt.12915 article EN Dental Traumatology 2023-11-30

Although titanium has been traditionally used as the gold standard for dental implants, recent years have seen widespread application of zirconia implants given their superiority with regards to reduced bacterial adhesion, inflammation and cellular-interaction in terms bio-compatibility. The JAK-STAT signaling pathway plays an important role bone remodeling formation. aim study was investigate activation through different cytokines osteoblast-like cells (MG-63) on comparison discs. IFN-γ...

10.3390/ma15165621 article EN Materials 2022-08-16

A status report of dental implantology in Switzerland has already been performed 1994 and 2006. The present study, based on these former surveys, aimed to update results for the year 2016. To this end, a questionnaire was sent all dentists who were members Swiss Dental Society (SSO) at time survey. asked personal background data obtained information about dentists' knowledge concepts when using implants, extent which they used implants specific implant systems, selected previous surveys. Out...

10.61872/sdj-2020-06-660 article EN cc-by-nc SWISS DENTAL JOURNAL SSO – Science and Clinical Topics 2020-06-15

Several properties of bio-inspired surfaces like chemical composition, surface topography, hydrophilicity and even charge could influence bacterial adhesion to implant materials. Therefore, a nanostructured is being investigated avoid colonization by their physico-mechanical aspects.Both smooth rough-surfaced titanium (PT, SLA) zirconia (M ZLA) were used as controls. Titanium SLA was modified two-step-etching create surface. Antibacterial the materials tested Porphyromonas gingivalis (ATCC...

10.1080/20002297.2017.1325241 article EN cc-by Journal of Oral Microbiology 2017-05-31

Surface patterning of bio-compatible titanium (Ti) shows a growing interest in the medical field. The engineering material surfaces can achieve bactericidal properties and osteointegration improvements order to develop implants. Spikes-like surface morphologies have already demonstrated development promising properties. A barely new method produce nanometric-sized cones on consists helium (He) ion irradiation using low energies (≈ 100 eV) temperatures comprised between 0.25 < T/Tm 0.5 (with...

10.1016/j.surfin.2022.102428 article EN cc-by Surfaces and Interfaces 2022-11-08
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