A5009264963- Microtubule and mitosis dynamics
- Genetic and Kidney Cyst Diseases
- Renal and related cancers
- Medicinal Plants and Neuroprotection
- Drug-Induced Hepatotoxicity and Protection
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Cellular Mechanics and Interactions
- Fungal Biology and Applications
- Phytochemicals and Antioxidant Activities
- Adipokines, Inflammation, and Metabolic Diseases
- Phytochemistry and Bioactivity Studies
- Agricultural Systems and Practices
- Maternal and Neonatal Healthcare
- Complementary and Alternative Medicine Studies
- Child Nutrition and Water Access
- Alkaloids: synthesis and pharmacology
- Medicinal plant effects and applications
- Coconut Research and Applications
- Medicinal Plant Research
- Chemotherapy-induced organ toxicity mitigation
- Fisheries and Aquaculture Studies
- Phytochemistry and biological activity of medicinal plants
- Big Data and Digital Economy
Jahangirnagar University
2011-2024
International Islamic University Chittagong
2024
East West University
2023
University of Bristol
2022
Green University of Bangladesh
2022
Heidelberg University
2015-2020
DKFZ-ZMBH Alliance
2015-2020
Ministry of Health and Family Welfare
2018
Bangladesh Agricultural University
2017
German Cancer Research Center
2016-2017
Several types of organophosphorous and carbamate pesticides have been used extensively by the farmers in Bangladesh during last few decades. Twenty seven water samples collected from both paddy vegetable fields Savar Dhamrai Upazilas were analyzed to determine occurrence distribution organo-phosphorus (chlorpyrifos, malathion diazinon) (carbaryl carbofuran) pesticide residues. A high performance liquid chromatograph instrument equipped with a photodiode array detector was concentrations...
Significance Cell migration and adhesion play critical roles in animal development tumor metastasis are regulated by protein phosphorylation. Here we identified the human phosphatase hCDC14A (human cell-division cycle 14A) as F-actin binding at leading edge that regulates both processes. Loss of activity promotes cell mobility reduces adhesion. Importantly, cells devoid were more invasive a colony-forming assay. Database analysis indicates expression is frequently down-regulated cancer...
Background Increasing the level of birth preparedness and complication readiness (BP/CR) is one key interventions to promote optimal utilization skilled maternal health services. It therefore essential determine women's ability recognize danger signs BP/CR. This information can be used design more effective interventions. Objectives study was conducted knowledge in recognition complications, factors associated with BP/CR rural Matlab, Bangladesh. Methods A community-based cross-sectional...
CDC14 is an essential dual-specificity phosphatase that counteracts CDK1 activity during anaphase to promote mitotic exit in Saccharomyces cerevisiae Surprisingly, human CDC14A not for cell cycle progression. Instead, it regulates migration and adhesion. Little known about the substrates of hCDC14A counteracting kinases. Here, we combine phospho-proteome profiling proximity-dependent biotin identification identify substrates. Among these targets were actin regulators, including tumor...
Highly efficient genome editing can be achieved through targeting an endonuclease to specific locus of interest. Engineered zinc-finger nuclease (ZFN) and CRISPR-associated protein-9 (Cas9) offer such elegant approach for in vertebrate cells. In this study, we have utilized ZFN Cas9-catalyzed double strand break followed by homologous recombination-mediated incorporation premature stop codon selection marker target human cell division cycle 14A (hCDC14A) 14B (hCDC14B) genes. Targeting the...
We describe a novel set of domain-specific markers that can be used in genetic studies, and we two examples to show loss stem cells monopteros background. Multicellular organisms defined by their ability establish distinct cell identities, it is therefore critical importance distinguish types. One step leads identity specification activation unique sets transcripts. This property often exploited order infer identity; the availability good marker lines is, however, poor Arabidopsis embryo....
Aloe vera is a semi-tropical plant of Liliaceae family which has wide range applications in traditional medicine. In the present study, we sought to investigate heptaoprotective potential gel as diet supplement. To achieve this goal, have designed vitro and vivo experimental models chemical-induced liver damage using male Sprague-Dawley rat. model, its effect was evaluated on Fenton's reaction-induced lipid peroxidation. Co-incubation with significantly reduced generation peroxide (LPO)....
The in vitro oxidative stress induced by ethanol/Fentons reaction rat liver homogenates decreased significantly the presence of Syzygium cumini seed extract, suggesting protective effect extract against liver. To corroborate effects an vivo experiment, 24 rats were divided into four groups: control, S. seed-extract-administered (SE), 15% ethanol-fed (Alc) and Alc+SE rats. oral administration (400 mg/kg BW.day) for 7 weeks levels LPO rats, that not only obstructed free radical production...
The budding yeast phosphatase Cdc14 has a central role in mitotic exit and cytokinesis. Puzzlingly, uniform picture for the three human CDC14 paralogues CDC14A, CDC14B CDC14C cell cycle control not emerged to date. Redundant functions between phosphatases could explain this unclear picture. To address possibility of redundancy, we tested expression analysed progression cells with single double deletions genes. Our data suggest that is expressed RPE1 cells, excluding function line. Single-...
The primary cilium is a sensory organelle, receiving signals from the external environment and relaying them into cell. Mutations in proteins required for transport result ciliopathies, group of genetic disorders that commonly lead to malformation organs such as kidney, liver eyes skeletal dysplasias. motor dynein-2 kinesin-2 mediate retrograde anterograde transport, respectively, cilium. WDR34 (also known DYNC2I2), intermediate chain, maintenance cilia function. Here, we investigated...
Aminoglycosides are one of the categories antibiotics most frequently used in treating several cattle diseases at Central Cattle Breeding and Dairy Farm (CCBDF), Savar,Dhaka,Bangladesh. Untreated veterinary clinical healthcare waste (VCHW) diseased CCBDF which directly disposed to surrounding may contribute antibiotic resistant bacteria pollution (ARB) pollution. The investigation analyses role VCHW spreading ARB. Here we studied：1) data treatment history; 2) total counts fecal samples...
Ganoderma lucidum is a medicinal mushroom that has been used since ancient times. We studied whether chronic oral administration of G. extract withstands increases in levels proinflammatory TNF-α and lipid peroxide (LPO), an indicator oxidative stress, the gingival tissues periodontitis model rats. was initially examined for inhibition vitro produced by Fenton's reagents whole homogenates fresh gum from Prior to vivo experiments with rats, quantitatively tested its total polyphenol and/or...
The study is concentrated with the role of inherent antioxidants content selected mango varieties on quality and shelf life developed products. Three as gutti, ashina, langda two products; bar fruit drinks were used in this study. Antioxidant contents three pulp microbial loads assessed. All contained vitamin A, beta carotene, C an antioxidant their higher gutti variety than other varieties; Asina Langda. Antioxidants made effective to resist load No growth was observed within months...
Smoking of cigarettes worsens morbidity and mortality rates by prompting cancer, pulmonary, cardiovascular, oral diseases.Despite having all these severe risks smoking, the habit is unacceptably widespread, particularly among teenagers in many countries, including Bangladesh.In this investigation, acute effect cigarette smoking on oxidative stress inflammation (Tumor Necrosis Factor-TNF-) has been analyzed smoke (CS)-exposed rats.Exposure vivo significantly increased levels Lipid...
Abstract Lablab purpureus (L) bean is an undervalued or underutilized orphan crop in many tropical countries, where different forms of malnutrition are associated with stunting growth and cognitive deficiencies. We previously reported that L. contains ω‐3 α‐linolenic acid (ALA, C18:3, ω‐3), which can act as the precursor docosahexaenoic (DHA, C22:6, ω‐3). Inadequate level DHA impairs growth, development, performance. Therefore, we evaluated if supplementation seed flour (LPS) affects...