Thyroid hormones are involved in the regulation of many physiological processes and regulate gene transcription by binding to their nuclear receptors TRα TRβ. In absence triiodothyronine (T3), unliganded (aporeceptors) do bind DNA repress target genes. The role thyroid hormone aporeceptors as repressors was observed hypothyroid adult mice, but its relevance nonpathological conditions remained be determined. Here we show that, normal mouse fetus, heart rate well expression TR β several genes...

<b>BACKGROUND AND PURPOSE:</b> Sparganosis is a rare parasitic infection in humans by larval cestode of the genus Spirometra. Preoperative diagnosis cerebral sparganosis past has been very difficult. Our objective was to evaluate CT and MR features order make definite diagnosis. <b>MATERIALS METHODS:</b> We retrospectively reviewed 25 patients (13 male 12 female; age range, 9–83 years) who proved have sparganosis. Fifteen underwent imaging: 2 had scanning, remaining 8 both scanning. focused...

Background: Heart failure (HF) represents the terminal stage of various cardiovascular diseases, including myocardial infarction (MI), with energy metabolism playing a crucial role in its progression. Fatty acid oxidation (FAO) constitutes primary pathway metabolism, providing 60%-90% cardiac through FAO. However, precise mechanisms regulating this process remain elusive.Methods: In study, we investigated Meteorin-like protein (Metrnl) MI-induced remodeling and dysfunction using rat models...

Two skeletally immature female dogs were each investigated for chronic weight-bearing thoracic limb lameness. The first patient was lame 2 months following a tumble whilst playing, and the second had been intermittently since 3 weeks of age. In both cases, radiographic examination shoulder revealed fissuring caudal humeral head consistent with an incomplete proximal Salter-Harris type IV fracture Enoki-mushroom-like appearance fragment, where two heads rise from common stem. There secondary...

ABSTRACT In this analytical cross‐sectional method comparison study, we evaluated brain MR images in 30 dogs and cats with without using a DICOM‐based deep‐learning (DL) denoising algorithm developed specifically for veterinary patients. Quantitative was performed by measuring signal‐to‐noise (SNR) contrast‐to‐noise ratios (CNR) on the same T2‐weighted (T2W), T2‐FLAIR, Gradient Echo (GRE) each patient (native after denoising) identical regions of interest. Qualitative comparisons were then...

Abstract Objective The aim of this study was to develop and describe pre‐ intra‐operative sentinel lymph node (SLN) mapping techniques in dogs with thyroid carcinoma. Study design A prospective, pilot clinical trial performed. Animals Six client‐owned unilateral carcinoma no overtly metastatic locoregional nodes (LNs) were enrolled. Methods All underwent preoperative indirect computed tomography (CT)‐lymphography (CTL) peritumoral iohexol injection intraoperative SLN a visible dye (methylene...

ABSTRACT A 9‐year‐old male neutered Labrador Retriever was referred for azotemia and bilateral renomegaly. An abdominal ultrasound revealed severe renomegaly with septated subcapsular cystic anechoic lesions, consistent renal lymphangiectasia. Despite conservative management, the patient died. Necropsy histopathology confirmed dilated vascular structures. Renal lymphangiectasia is a rare, benign dilation of lymphatics previously reported in human medicine. This case represents first...

The objectives of this study were to establish the sensitivity and negative predictive value radiography for acute spinal osseous lesions in canine trauma patient, evaluate interobserver variability radiographic assessment spine traumatized dogs. This was a retrospective multiple observer blinded study. population included 30 patients that presented following trauma, with clinical signs attributable column. Radiography computed tomography (CT) performed all cases. Radiographic interpretation...

Cerebrovascular accidents, or strokes, and gliomas are common intraaxial brain lesions in dogs. An accurate differentiation of these two is necessary for prognosis treatment decisions. The magnetic resonance (MR) imaging characteristics 21 dogs with a presumed cerebrovascular accident 17 glioma were compared. MR findings reviewed retrospectively by three observers unaware the final diagnosis. Statistically significant differences between appearance accidents identified based on lesion...

This article describes the findings in three dogs with histopathologically confirmed pancreatic insulinoma using dual-phase computed tomographic angiography (CTA). In all dogs, CTA identified lesions not seen on ultrasonography, including actual identification of primary neoplasm two dogs. were agreement surgical and histopathological findings. insulinomas found to have a strong enhancement during arterial phase study but at other phases, which stresses importance tomography for diagnosis...

To determine the sensitivity, positive predictive value, and interobserver variability of CT in detection bullae associated with spontaneous pneumothorax dogs.Retrospective case series.19 dogs caused by rupture bullae.Dogs that had for confirmed at surgery (median sternotomy) or necropsy were included. Patient signalment, protocols, bulla location, size, number obtained from medical records. Computed tomographic images reviewed 3 board-certified radiologists who reported on as well...

Abdominal lymph node enlargement is frequently noted sonographically. Certain sonographic features can be used to suggest whether lymphadenopathy more likely benign or malignant. Specific changes in size, shape, echogenicity, and Doppler flow patterns have an association with malignancy. In this retrospective case–control study, the between abdominal heterogeneity malignancy was evaluated. Twenty‐three canine 18 feline patients ultrasonographically heterogeneous nodes were evaluated for...

Odontogenic neoplasms are locally invasive oral tumors in dogs. The purpose of this retrospective study was to describe CT characteristics for varying histopathologic types canine odontogenic neoplasms. A board‐certified veterinary radiologist who unaware histologic findings reviewed and scored imaging studies. total 29 dogs were included the study. Twenty‐three these had concurrent dental radiographs. most common all tumor a direct association with or region multiple teeth 96.4% (27/28),...

Abstract One can acquire high‐resolution pulmonary and cardiac images in live rodents with MR microscopy by synchronizing the image acquisition to breathing cycle across multiple breaths, gating cycle. The precision which one synchronize motion defines ultimate resolution limit that be attained such studies. present work was performed evaluate how reliably structures return same position from breath beat prolonged period required for microscopy. Radiopaque beads were surgically glued...

Increased signal intensity in one of the collateral ligaments distal interphalangeal (DIP) joint sound horses images acquired using a low‐field magnet with vertical orientation magnetic field was investigated as possible manifestation magic angle effect. Three isolated equine digits were imaged following pulse sequences: (1) spin echo T1, (2) turbo proton density and T2, (3) 3D gradient different positions by mildly changing long axis digit, dorsal plane, relative to field. The ligament...

A prospective, cross-sectional study was performed to qualitatively and quantitatively compare the echogenicity of renal cortex relative liver in healthy dogs. Twenty-five normal adult dogs were examined ultrasonographically. Three standard B-mode images (8.0 MHz) three tissue harmonic cranial pole right kidney adjacent caudate lobe obtained. Renal hepatic echogenicities compared by two observers. Subsequently, regions interest (ROIs) drawn parenchyma at equal depths on each image, using...

Urethral obstruction is a life-threatening form of feline lower urinary tract disease. Ultrasonographic risk factors for reobstruction have not been previously reported. Purposes this retrospective cross-sectional study were to describe ultrasound findings in cats following acute urethral and determine whether associated with reobstruction. Inclusion criteria physical examination history consistent obstruction, an abdominal including full evaluation the system within 24 h hospitalization, no...

The vertebral heart score or size (VHS) measurement is routinely used to provide a more objective of cardiomegaly in dogs. However, breed body conformation can influence the VHS. To assess specific VHS for Australian Cattle Dog, left-to-right lateral, right-to-left dorsoventral and ventrodorsal thoracic radiographs from 20 individuals free cardiac pulmonary disease were obtained. mean was significantly higher Dog (10.5 ± 0.4 vertebrae), when compared with average 100 normal dogs different...

The purpose of this study was to investigate the association between renal hypoechoic subcapsular thickening observed ultrasonographically and presence lymphosarcoma in cats. ultrasonography database retrospectively searched for cats that underwent ultrasound examination guided needle aspirate, biopsy, or necropsy. One radiologist unaware final diagnosis evaluated images other abnormal findings. Fifty‐four met inclusion criteria. Hypoechoic found 21 which 17 had lymphosarcoma; remaining four...

Helical computed tomography angiography was used to evaluate the renal vascular anatomy of potential feline donors. One hundred and fourteen angiograms were reviewed. The vessels characterized as single without bifurcation, with double, or triple. Multiplicity most commonly seen for right vein (45/114 vs. 3/114 multiple left veins, 0/114 arteries, 8/114 arteries). kidney 13.3 times more likely than have veins. Additional variants included double caudal vena cava an accessory artery. For...

Contrast-enhanced multiphase magnetic resonance angiography (CE-MRA) was used in 17 dogs with a suspected congenital portal vascular anomaly. Portal anomalies were identified 16 of the dogs. Eleven had single intrahepatic portocaval shunt (two central divisional, three right and six left divisional), one dog double shunt, hepatic arteriovenous malformation, complex porto-caval shunt. Two an extrahepatic portosystemic no dog. Total imaging time <10 min image quality good to excellent all...