Abstract Induced pluripotent stem cell-derived neural cells (iNSCs) have significant potential as an autologous, multifunctional cell therapy for stroke, which is the primary cause of long term disability in United States and second leading death worldwide. Here we show that iNSC transplantation improves recovery through neuroprotective, regenerative, replacement mechanisms a novel ischemic pig stroke model. Longitudinal multiparametric magnetic resonance imaging (MRI) following demonstrated...

Efforts to develop stroke treatments have met with limited success despite an intense need produce novel treatments. The failed translation of many these therapies in clinical trials has lead a close examination the therapeutic development process. One major factors believed be limiting effective screening is absence animal model more predictive human responses pig may potentially fill this gap gyrencephalic brain that larger size similar gray-white matter composition humans than traditional...

Magnetic resonance (MR) imaging characteristics are commonly used to help predict intracranial disease categories in dogs, however, few large studies have objectively evaluated these characteristics. The purpose of this retrospective study was evaluate MR that been differentiate neoplastic, inflammatory, and vascular diseases a large, multi-institutional population dogs. Medical records from three veterinary teaching hospitals were searched over 6-year period for dogs had diagnostic quality...

ABSTRACT In this analytical cross‐sectional method comparison study, we evaluated brain MR images in 30 dogs and cats with without using a DICOM‐based deep‐learning (DL) denoising algorithm developed specifically for veterinary patients. Quantitative was performed by measuring signal‐to‐noise (SNR) contrast‐to‐noise ratios (CNR) on the same T2‐weighted (T2W), T2‐FLAIR, Gradient Echo (GRE) each patient (native after denoising) identical regions of interest. Qualitative comparisons were then...

The goal of this study was to establish an SPIO-based cell-tracking method in ovine model tendonitis and determine if may be useful for further cellular therapies vivo. Functional assays were performed on labeled unlabeled cells ensure that no significant changes induced by intracellular SPIOs. Following biosafety validation, tendon lesions mechanically (n = 4) or chemically four sheep scanned ex vivo at 7 14 days the presence distribution intralesional cells. Ovine MSCs with 50 µg SPIOs/mL...

Background Although Chiari‐like malformation ( CM ) and syringomyelia SM have been described in many small breed dogs, the prevalence clinical manifestations of this complex not documented a large cohort American Brussels Griffon ABG dogs. Objectives To characterize magnetic resonance imaging MRI features breed. Animals Eighty‐four Kennel Club registered dogs were recruited. Methods Prospective study. Complete histories neurologic examinations obtained before . Images blindly reviewed...

The purpose of this study was to investigate whether platelet-rich plasma (PRP) enhances osseous healing in conjunction with a high tibial osteotomy dogs.Randomized controlled trial.Sixty-four client-owned pet dogs naturally occurring rupture the anterior cruciate ligament and that were be treated (tibial plateau leveling osteotomy) randomized into treatment or control group. Dogs group received autologous activated calcium chloride bovine thrombin produce well-formed PRP gel placed at time...

Fourteen horses with septic arthritis underwent high‐field (1.5 T) magnetic resonance imaging (MRI). Septic was diagnosed based on results from historical and clinical findings, synovial fluid analyses culture, radiographic, ultrasonographic, arthroscopic, histopathologic findings. MR findings included diffuse hyperintensity within bone extracapsular tissue fat‐suppressed images in 14/14 (100%), joint effusion, proliferation, capsular thickening 13/14 (93%), sclerosis 11/14 (79%), evidence...

OBJECTIVE To compare the accuracy of ultrasonography and MRI for diagnosing medial meniscal lesions in dogs with cranial cruciate ligament (CCL) deficiency. DESIGN Diagnostic test evaluation. ANIMALS 26 (31 stifle joints) CCL PROCEDURES A single surgeon physically examined each dog performed arthroscopy affected joints to identify lesions. Video recordings arthroscopic procedure were saved subsequently reviewed by same a second working independently blinded results all examinations....

Abstract Objective To describe the clinical details, surgery, postoperative imaging, and short to mid‐term outcome after cranioplasty with titanium mesh in dogs large skull tumors. Study Design Case series. Animals Client‐owned tumors (n=5). Methods All were removed via craniectomy a sheet of was contoured reconstruct calvarial defect sutured surrounding musculature. Results Four had multilobular bone 1 dog soft tissue sarcoma invading cranial vault. Neurologic examination unchanged or...

Three bald eagles (Haliaeetus leucocephalus) found along highways and unable to fly were presented for evaluation. All exhibited sternal recumbency, as well flaccid hind limb tail paralysis. Vertebral column spinal cord trauma suspected the cause. One bird died, whereas remaining 2 birds stabilized diagnostic imaging studies. 3 evaluated by radiography magnetic resonance (MRI) diagnosis prognosis in live birds. Radiographic findings all inconclusive, MRI results showed extensive damage of...

A 5-year-old, spayed female cat was referred because of a mass in the cranial mediastinum noted on thoracic radiographs. thymoma diagnosed following ultrasound and biopsy mass. Treatment initiated with coarse-fraction radiation therapy using external-beam (four fractions 5 Gy). The responded, but granulocytopenia developed. Bone marrow examination showed myeloid to erythroid ratio approximately 1:1, left shift within line. These findings, as well lack toxic changes peripheral blood...

Abstract Magnetic resonance imaging (MRI) is a common test for dogs with suspected intradural spinal cord lesions, however studies on diagnostic performance this are lacking. Objectives of multi‐institutional, retrospective, case‐control study were to estimate sensitivity and specificity MRI (1) distinguishing between histopathologically confirmed disease versus degenerative myelopathy in dogs, (2) categorizing diseases as neoplastic, inflammatory, or vascular; (3) determining tumor type...

A 25-year-old, female eclectus parrot (Eclectus roratus) presented for dyspnea 3 weeks after anesthesia and surgery egg yolk coelomitis. Radiography, computed tomography, tracheoscopy revealed multiple tracheal strictures spanning a length of 2.6 cm in the mid to distal trachea. Histopathologic examination mild fibrosis, inflammation, hyperplasia consistent with acquired strictures. Tracheal resection was not considered possible because affected The were resected endoscopically, repeated...

O bjective : To describe the patterns of enhancement extradural intervertebral disc on chemically fat saturated gadolinium‐enhanced magnetic resonance images and to investigate clinical pathological associations with enhancement. M ethods Medical records were reviewed from 30 dogs histopathologically confirmed disease a T1‐weighted postcontrast sequence. R esults Median duration neurological signs was 4 days most common grade severity II, seen in 46·6% dogs. Homogeneous, heterogeneous...

A 9‐year‐old spayed female Scottish terrier presented with an 8‐day history of progressive paraparesis. Neurological examination suggested a painful T3‐L3 myelopathy. Multifocal uniform contrast‐enhancing masses involving the vertebral bodies, pedicles, laminae, and spinous processes two vertebrae compressing spinal cord were present on MRI. Fluoroscopic‐guided fine needle aspiration one lesions revealed predominantly lymphoblastic population cells compatible diagnosis lymphoma. To authors’...

Ultrasound‐guided intralesional injection of mesenchymal stem cells (MSCs) is held as the benchmark for cell delivery in tendonitis. The primary objective this study was to investigate immediate distribution following MSCs. Unilateral superficial digital flexor tendon (SDFT) lesions were created forelimb six horses and injected with 10 × 6 MSCs labeled superparamagnetic iron oxide nanoparticles (SPIOs) under ultrasound guidance. Assays performed confirm that there no significant changes...

A 5‐year‐old Chihuahua was examined for peracute pain and paraparesis. Neuroanatomic localization consistent with a symmetric T3‐L3 myelopathy. Computed tomography (CT) of the T9‐L5 vertebrae normal. Myelography disclosed attenuation subarachnoid space from T11 to L1, spinal cord swelling. CT following myelogram focal area intramedullary iodinated contrast medium at T13‐L1. At surgery, intervertebral disc material removed cord. Based on findings in this patient, herniation should be...

A 23-yr-old female spayed bobcat (Lynx rufus) presented with a 1-wk history of hypersalivation. On examination, the right mandible was markedly thickened, mandibular dental arcade missing, and oral mucosa over ulcerated thickened. Skull radiographs fine needle aspirate cytology were supportive squamous cell carcinoma. The euthanized as result its poor prognosis. Necropsy confirmed diagnosis carcinoma mandible. To authors' knowledge, this is first report in bobcat.

Abstract A 4‐month‐old intact female English Springer Spaniel presented to the University of Georgia Veterinary Teaching Hospital for evaluation unilateral, progressive exophthalmos oculus sinister (OS) 2 weeks’ duration. Complete ophthalmic examination revealed moderate OS and lateral globe deviation. No other abnormalities were noted on physical or examination, ocular ultrasound, complete bloodwork, thoracic radiography. Skull computed tomography (CT) a large, focal, smoothly irregular,...

Abstract Entotherapy an image‐guided drug‐eluting microcylinder platform, has the potential to bypass limitations of systemic chemotherapy use in treatment canine brain tumours. Gliomas, which are common dogs and also represent majority fatal tumours humans, can be amenable with temozolomide. Biopolymer microcylinders conjugated temozolomide gadolinium were implanted into partially resected four client‐owned gliomas. All presented generalized seizures had mild no neurologic deficits at time...