A5089601367- Circadian rhythm and melatonin
- Light effects on plants
- Photoreceptor and optogenetics research
- Dietary Effects on Health
- Sleep and Wakefulness Research
- Spaceflight effects on biology
- Genetics, Aging, and Longevity in Model Organisms
- Extracellular vesicles in disease
- Plant and Biological Electrophysiology Studies
- 3D Printing in Biomedical Research
- Hematopoietic Stem Cell Transplantation
- Cancer Cells and Metastasis
- Chronic Lymphocytic Leukemia Research
- Plant Molecular Biology Research
- Phagocytosis and Immune Regulation
- MicroRNA in disease regulation
- Gene Regulatory Network Analysis
- Photosynthetic Processes and Mechanisms
- Cellular Mechanics and Interactions
- Acute Myeloid Leukemia Research
University of California, San Francisco
2023-2025
Charité - Universitätsmedizin Berlin
2020-2025
Novo Nordisk (Denmark)
2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020-2022
Humboldt-Universität zu Berlin
2020-2022
Freie Universität Berlin
2020-2022
The circadian clock is an evolutionarily highly conserved endogenous timing program that structures physiology and behavior according to the time of day. Disruption rhythms associated with many common pathologies. emerging field medicine aims exploit mechanisms clock–disease interaction for clinical diagnosis, treatment, prevention. In this Essay, we outline principle approaches medicine, highlight development in selected areas, point out open questions challenges. Circadian has unambiguous...
Paracrine TGF-β signaling is crucial to maintain robust and coherent circadian rhythms of peripheral oscillator networks.
Abstract The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administration with the rhythm can enhance treatment efficacy minimize side effects. Yet, uncovering optimal timings remains challenging, limiting their widespread adoption. In this work, we introduce high-throughput approach integrating live-imaging data...
Abstract The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administration with the rhythm can enhance treatment efficacy minimize side effects. Yet, uncovering optimal timings remains challenging, limiting their widespread adoption. In this work, we introduce novel high-throughput approach integrating live-imaging...
A defining property of circadian clocks is temperature compensation, characterized by the resilience their near 24-hour free-running periods against changes in environmental within physiological range. While compensation evolutionary conserved across different taxa life and has been studied many model organisms, its molecular underpinnings remain elusive. Posttranscriptional regulations such as temperature-sensitive alternative splicing or phosphorylation have described underlying reactions....
Normal hematopoiesis requires constant prolific production of different blood cell lineages by multipotent hematopoietic stem cells (HSC). Stem- and progenitor- need to balance dormancy with proliferation. How genetic alterations impact frequency, lineage potential, metabolism HSC is largely unknown. Here, we compared induced expression KRAS
Abstract The pleiotropic roles of nSMase2-generated ceramide include regulation intracellular signaling and exosome biogenesis. We investigated the effects eliminating nSMase2 on early advanced PDA, including its influence microenvironment. Employing KPC mouse model pancreatic cancer, we demonstrate that epithelial ablation reduces neoplasia promotes a PDA subtype switch from aggressive basal-like to classical. elimination prolongs survival mice, hinders vasculature development, fosters...
ABSTRACT The pleiotropic roles of nSMase2-generated ceramide include regulation intracellular signaling and exosome biogenesis. We investigated the effects eliminating nSMase2 on early advanced PDA, including its influence microenvironment. Employing KPC mouse model pancreatic cancer, we demonstrate that epithelial ablation reduces neoplasia promotes a PDA subtype switch from aggressive basal-like to classical. elimination prolongs survival mice, hinders vasculature development, fosters...
Abstract A defining property of circadian clocks is temperature compensation, characterized by the resilience free-running periods against changes in environmental temperature. As an underlying mechanism, balance or critical reaction hypothesis have been proposed. While former supposes a temperature-dependent balancing reactions with opposite effects on period, latter assumes insensitivity certain period determining regulations upon changes. Posttranscriptional such as temperature-sensitive...