A5024097466- Chemistry and Chemical Engineering
- Nicotinic Acetylcholine Receptors Study
- Chemical Synthesis and Analysis
- Receptor Mechanisms and Signaling
- Various Chemistry Research Topics
- Sustainability in Higher Education
- Energy, Environment, Economic Growth
- Environmental Education and Sustainability
- Innovation and Knowledge Management
- Ion channel regulation and function
- Management and Organizational Studies
- History and advancements in chemistry
- Neuroscience and Neuropharmacology Research
- Innovation Diffusion and Forecasting
- Biochemical and Structural Characterization
- Force Microscopy Techniques and Applications
- Cellular transport and secretion
- Advanced Electron Microscopy Techniques and Applications
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Lipid Membrane Structure and Behavior
- Microstructure and mechanical properties
- Nanotechnology research and applications
- Innovative Teaching and Learning Methods
- Cardiac electrophysiology and arrhythmias
University of Oregon
2000-2019
Institute of Molecular Biology
2000
Lawrence Berkeley National Laboratory
2000
University of California, Berkeley
2000
Howard Hughes Medical Institute
2000
University of North Carolina at Chapel Hill
1994
University of Utah
1989-1993
Recent advances in single molecule manipulation methods offer a novel approach to investigating the protein folding problem. These studies usually are done on molecules that naturally organized as linear arrays of globular domains. To extend these techniques study proteins normally exist monomers, we have developed method synthesizing polymers solid state. By introducing cysteines at locations where bacteriophage T4 lysozyme contact each other crystal and taking advantage alignment provided...
Abstract Many neuropathological and experimental studies suggest that the degeneration of dopaminergic terminals axons precedes demise neurons in substantia nigra, which finally results clinical symptoms Parkinson disease (PD). The mechanisms underlying this early axonal are, however, still poorly understood. Here, we examined effects overexpression human wildtype alpha-synuclein ( α Syn-WT), a protein associated with PD, its mutant variants Syn-A30P -A53T on neurite morphology functional...
We investigate the emergence and growth of “green chemistry”—an effort by chemists to encourage other reduce health, safety, environmental impacts chemical products processes—to explore how occupational members, absent external triggers for change, influence their peers do work. Using extensive interviews, archival data, observations, we find that advocates simultaneously advanced different frames specified utility making change: (1) a normalizing frame, positioning green chemistry as...
Conantokin-T, a 21-amino acid peptide which induces sleep-like symptoms in young mice was purified from the venom of fish-hunting cone snail, Conus tulipa. The amino sequence determined and verified by chemical synthesis. has 4 residues modified acid, gamma-carboxyglutamate (Gla). is: Gly-Glu-Gla-Gla-Tyr-Gln-Lys-Met-Leu-Gla-Asn-Leu-Arg-Gla-Ala-Glu-Val-Lys- Lys-Asn-Ala-NH2. Conantokin-T inhibits N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx central nervous system neurons. This...
This Feature summarizes the advances in green chemistry education during last 25 years and highlights some new strategies being developed to support curricular reform at undergraduate level. The infusion of into curriculum has enabled educators improve lab safety, address facilities limitations, modernize curriculum. Strategic partnerships investments rapid dissemination capacity building supported development early educational materials networks interested collaborative efforts transform...
What is the history and justification of claim that chemistry "the central science"? Are our students able to see appreciate such centrality knowledge in curriculum as well its broader interconnections with other fields study societal issues? In this editorial for special issue Reimagining Chemistry Education: Systems Thinking, Green Sustainable Chemistry, we, guest editors, highlight case made collective contributions systems thinking, including green sustainable chemistry, shows promise an...
ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTGoing Green: Lecture Assignments and Lab Experiences for the College CurriculumIrvin J. Levy , Julie A. Haack James E. Hutchison Mary M. Kirchhoff View Author Information Department of Chemistry, Gordon College, Wenham, MA 01984 University Oregon, Eugene, OR 97403 Materials Science Institute, Education Division, American Chemical Society, Washington, DC 20036Cite this: Chem. Educ. 2005, 82, 7, 974Publication Date (Web):July 1, 2005Publication...
The venoms of fish-hunting Conus contain paralytic conotoxins and an unprecedented variety other biologically-active peptides. Particularly noteworthy are peptides which inhibit calcium entry into neurons, the conantokins w-conotoxins target NMDA receptors voltage-sensitive Ca channels respectively.The at least four residues γ-carboxyglutamate (Gla), a post-translationally modified amino acid. Conantokins folded α-helical conformation bind acidic membranes in calcium-dependent manner. Upon...
This paper describes a collaborative project to design and teach general education science course, Chemistry of Sustainability. Our goal was show how chemistry plays central role in addressing the grand challenges protecting environment human health by developing knowledge tools that meet our basic needs for energy, clean water, consumer products. Course content designed using case-study approach illustrates chemical concepts including atomic structure, bonding, intermolecular forces,...