A5004469557- Oxidative Organic Chemistry Reactions
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Chemical synthesis and alkaloids
- Fluorine in Organic Chemistry
- Synthesis and Reactions of Organic Compounds
- Vanadium and Halogenation Chemistry
- Synthetic Organic Chemistry Methods
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Reactions
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- Inorganic and Organometallic Chemistry
- Asymmetric Hydrogenation and Catalysis
- Chemistry and Chemical Engineering
- Catalytic C–H Functionalization Methods
- Livestock and Poultry Management
- Cyclopropane Reaction Mechanisms
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Organic Chemistry Synthesis Methods
- Parathyroid Disorders and Treatments
- Metabolism and Genetic Disorders
- Molecular spectroscopy and chirality
- Chemical Reaction Mechanisms
- Synthesis and Catalytic Reactions
National Centre for Immunisation Research & Surveillance
2019
National Centre for Research
2019
The University of Sydney
2019
Research Triangle Park Foundation
2018
Park University
2014
Grupo Lederval (Spain)
2014
Institute of Molecular Biology and Biophysics
2014
Durham University
2005
Brigham and Women's Hospital
2002
Swansea University
1992-1998
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbonate extension. A versatile procedure for functionalization of acyclic homoallylic alcohols with moderate stereocontrolPaul A. Bartlett, James D. Meadows, Edward G. Brown, Akira Morimoto, and Karen K. JernstedtCite this: J. Org. Chem. 1982, 47, 21, 4013–4018Publication Date (Print):October 1, 1982Publication History Published online1 May 2002Published inissue 1 October...
Objective To estimate rates of respiratory syncytial virus (RSV)-associated hospitalisation across the age spectrum, and to identify groups at particular risk serious RSV-associated disease. Design, setting participants Retrospective review National Hospital Morbidity Database data for all hospitalisations in Australia, 2006–2015. Main outcomes measures RSV-coded by age, sex, Indigenous status, jurisdiction, seasonality (month year); hospital length stay; in-hospital deaths. Results During...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and structural analysis using 2-D NMR of sialyl Lewis X (SLex) (Lex) oligosaccharides: ligands related to E-selectin [ELAM-1] binding.Graham E. Ball, Roger A. O'Neill, Joanne Schultz, John B. Lowe, Brent W. Weston, Jon O. Nagy, Edward G. Brown, Christopher J. Hobbs, Mark D. BednarskiCite this: Am. Chem. Soc. 1992, 114, 13, 5449–5451Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June...
The pharmacological effects of antisense and siRNA oligonucleotides are hindered by the tendency these molecules to become entrapped in endomembrane compartments thus failing reach their targets cytosol or nucleus. We have previously used high throughput screening identify small that enhance escape from intracellular membrane termed such OECs (oligonucleotide enhancing compounds). Here, we report on structure-activity relationships a family analogs hit emerged our original screen. These...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDouble diastereoselection in the iodolactonization of 1,6-heptadiene-4-carboxylic acidsMark J. Kurth and Edward G. BrownCite this: Am. Chem. Soc. 1987, 109, 22, 6844–6845Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://pubs.acs.org/doi/10.1021/ja00256a045https://doi.org/10.1021/ja00256a045research-articleACS PublicationsRequest reuse permissionsArticle...
Sorting nexins (SNXs) are key regulators of the endosomal network. In designing an RNAi-mediated loss-of-function screen, we establish that 30 human SNXs only SNX3, SNX5, SNX9, SNX15 and SNX21 appear to regulate EGF receptor degradative sorting. Suppression results in a delay degradation arising from defect movement newly internalised EGF-receptor-labelled vesicles into early endosomes. Besides phosphatidylinositol 3-phosphate- PX-domain-dependent association endosomes, also associates with...
Abstract The synthesis of 5,10‐dideazaaminopterin by two independent routes is described. Condensation the piperidine enamine 4‐ p ‐carbomethoxyphenylbutyraldehyde ( 4 ) with ethoxymethylenemalononitrile followed treatment resultant arylethylenaminomalononitrile 5 methanolic ammonia produced 2‐amino‐3‐cyano‐5‐ ‐carbomethoxyphenethylpyridine 6 ). Cyclization aminocyanopyridine guanidine afforded 4‐amino‐4‐deoxy‐5,10‐dideazapteroic acid 8 Coupling pteroate intermediate glutamate yielded target...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSingle-step removal of the allyl ether protecting group with hydridotetrakis(triphenylphosphine)rhodium [(Ph3P)4RhH] and trifluoroacetic acidFrederick E. Ziegler, Edward G. Brown, Susan B. SobolovCite this: J. Org. Chem. 1990, 55, 11, 3691–3693Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 1990https://pubs.acs.org/doi/10.1021/jo00298a065https://doi.org/10.1021/jo00298a065research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselective synthesis of octahydro-3-oxospiro[benzofuran-2(3H),2'-[2H]pyran]systemsMark J. Kurth, Edward G. Brown, Estelita Hendra, and Hakon HopeCite this: Org. Chem. 1985, 50, 7, 1115–1117Publication Date (Print):April 1, 1985Publication History Published online1 May 2002Published inissue 1 April 1985https://pubs.acs.org/doi/10.1021/jo00207a039https://doi.org/10.1021/jo00207a039research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and antifolate properties of 10-alkyl-8,10-dideazaminopterinsJ. I. DeGraw, P. H. Christie, E. G. Brown, L. F. Kelly, R. Kisliuk, Y. Gaumont, M. SirotnakCite this: J. Med. Chem. 1984, 27, 3, 376–380Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/jm00369a024https://doi.org/10.1021/jm00369a024research-articleACS PublicationsRequest reuse...
The aza-Claisen rearrangement of ketene N-allyl-N,O-acetals has been applied to the diastereoselective construction precursors 2-quaternary 4-pentenoic acids (82-97% ds). Best yields are obtained when alkoxides used deprotonate intermediate oxazolinium salts.
Abstract
The discovery of a G-protein-coupled calcium-sensing receptor (CaR) almost decade ago has provided incontrovertible evidence the receptors role in critical maintenance systemic calcium homeostasis. Situated on chief cells parathyroid glands, CaR “senses” extracellular concentration and, turn, alters rate secretion hormone (PTH). is also functionally expressed bone, kidney, and gut-the three major organs involved Intracellular signal pathways to which couples include, but are not limited to,...
Quinizarin (3) has been converted in seven steps into the homochiral acetal (14) 69% overall yield, through a sequence involving reductive Claisen rearrangements of allyl ethers (8) and (20). The (15) four novel diastereomeric 9-chloroanthracyclines (31)-(34) by an unprecedented intramolecular acetal-alkene cyclization mediated tin(IV) chloride N,N-dimethylformamide.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN-Methyloxazolinium salts: diastereomer ratios by proton NMRMark J. Kurth, Edward G. Brown, and Owen H. W. DeckerCite this: Org. Chem. 1985, 50, 24, 4984–4986Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://pubs.acs.org/doi/10.1021/jo00224a073https://doi.org/10.1021/jo00224a073research-articleACS PublicationsRequest reuse permissionsArticle...
Journal Article The Children of the Sun: Mexican-Americans in Literature United States Get access States. By Rocard Marcienne. Translated by Edward G. Brown, Jr. (Tucson: University Arizona Press, 1989. xvii + 393 pp. Notes, bibliography, index. $45.00.) Yolanda Romero North Lake College, Irving, Texas Search for other works this author on: Oxford Academic Google Scholar Western Historical Quarterly, Volume 22, Issue 1, February 1991, Pages 85–86, https://doi.org/10.2307/968740 Published: 01 1991