Chen Kai-jie

ORCID: 0000-0001-9152-9337
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About
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Research Areas
  • Cancer-related molecular mechanisms research
  • Ophthalmology and Visual Impairment Studies
  • Corneal surgery and disorders
  • Wound Healing and Treatments
  • RNA Interference and Gene Delivery
  • MRI in cancer diagnosis
  • Bee Products Chemical Analysis
  • Seaweed-derived Bioactive Compounds
  • Growth Hormone and Insulin-like Growth Factors
  • Ferroptosis and cancer prognosis
  • Intraocular Surgery and Lenses
  • RNA modifications and cancer
  • Retinal Development and Disorders
  • Cytomegalovirus and herpesvirus research
  • Advanced Computational Techniques and Applications
  • Renal Transplantation Outcomes and Treatments
  • Cancer Research and Treatments
  • Biological and pharmacological studies of plants
  • Cancer, Hypoxia, and Metabolism
  • Medicinal Plant Pharmacodynamics Research

Affiliated Eye Hospital of Wenzhou Medical College
2022-2023

Wenzhou Medical University
2022-2023

Chinese Academy of Medical Sciences & Peking Union Medical College
2023

University of Shanghai for Science and Technology
2022

Shanghai University of Medicine and Health Sciences
2022

175th Hospital of People's Liberation Army
2017

Xiamen University
2017

Tianjin University of Science and Technology
2007

Guangdong Medical College
2005

Dopamine is a key neurotransmitter in the signaling cascade controlling ocular refractive development, but exact role and site of action dopamine D1 receptors (D1Rs) involved myopia remains unclear. Here, we determine whether retinal D1Rs exclusively mediate effects endogenous systemically delivered D1R agonist or antagonist mouse form deprivation (FDM) model. Male C57BL/6 mice subjected to unilateral FDM unobstructed vision were divided into following four groups: one noninjected three...

10.1523/jneurosci.1196-23.2023 article EN cc-by-nc-sa Journal of Neuroscience 2023-09-26

To learn more about the locations of dopamine D2 receptors (D2Rs) that regulate form-deprivation myopia (FDM), using different transgenic mouse models.One eye D2R-knockout (KO) mice and wild-type littermates was subjected to four weeks monocular FDM, whereas fellow served as control. Mice in both groups received daily intraperitoneal injections either D2R antagonist sulpiride (8 µg/g) or vehicle alone. FDM also induced retina- (Six3creD2Rfl/fl) fibroblast-specific (S100a4creD2Rfl/fl) D2R-KO...

10.1167/iovs.63.1.24 article EN cc-by-nc-nd Investigative Ophthalmology & Visual Science 2022-01-20

Recent studies have identified a role for ALKBH7 in the occurrence and progression of cancer, this protein is related to cellular immunity immune cell infiltration. However, prognostic immunotherapeutic value different cancers not been explored. In study, we observed high expression 17 low 5 compared paired normal tissues. Although did correlate relatively significantly with clinical parameters age (6/33), sex (3/33) stage (3/27) studied, results survival analysis reflect pan-cancer ALKBH7....

10.3389/fgene.2022.822261 article EN cc-by Frontiers in Genetics 2022-02-11

Currently, developing therapeutic strategies for chondrosarcoma (CS) remains important. Sennoside A (SA), a dianthrone glycoside from Senna and Rhubarb, is widely used as an irritant laxative, weight-loss agent, or dietary supplement, which possesses various bioactive properties such antiobesity, hypoglycemic activities. For the first time, our results suggested that cell proliferation metastasis were inhibited by SA in CS SW1353 cells. induced growth arrest inhibiting proliferation. The...

10.1155/2022/8063497 article EN Evidence-based Complementary and Alternative Medicine 2022-08-31

Oxytropis falcata has long been used to treat inflammation, sores, and bleeding in Tibet. However, the burn remedy underlying molecular mechanisms are not well understood. This study is aimed at assessing effect of falcate gel (OFG) on deep second-degree rats exploring its mechanism. Wistar with were treated OFG silver sulfadiazine. Immunohistochemical detections for EGF VEGF performed, ELISA EGF, VEGF, p38, IL-1β serum determined. Rats (25, 50 g/kg) consisted major...

10.1155/2017/3729547 article EN Evidence-based Complementary and Alternative Medicine 2017-01-01
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