purpose. Squamous metaplasia occurs in ocular surface diseases like Sjögren’s syndrome (SS). It is a phenotypic change whereby epithelial cells initiate synthesis of squamous cell-specific proteins such as small proline-rich protein 1B (SPRR1B) that result pathologic keratin formation on the surface. The authors hypothesized inflammation key inducer keratinization and SPRR1B represents an analytical biomarker for study molecular mechanisms. methods. Real-time quantitative RT-PCR...

Combining both morphological and genetic data, we assessed the validity of Lycodon meridionalis. Based on examination newly collected specimens from several provinces in China, found that diagnostic characters proposed previous literature to distinguish between L. meridionalis flavozonatus were no longer reliable. The phylogenetic relationships inferred a single mitochondrial gene (cyt b) fragment revealed well-supported monophyletic clade formed by flavozonatus, distances populations...

Purpose. To explore non-invasive, protein-based, membrane array technology as a means to evaluate the global immune and angiogenic profile of tear proteins in patients with active ocular cicatricial pemphigoid (OCP). Methods. Forty-three consisting cytokines, angiogenic/growth factors, immunoinflammatory modulators were measured by samples four control OCP during disease after treatment. Results. Signals for several distinct consistent molecular entities upregulated all relative controls. In...

Objective: This research was aimed to explore the efficacy of narrow-band imaging (NBI) on distinguishing degree dysplasia vocal fold leukoplakia.Methods: Patients were examined by flexible endoscopy, under white light endoscopy (WLE) and NBI. 78 lesions divided into two groups according NBI classification. Group 1: non-dysplasia (ND), including squamous hyperplasia with hyperkeratosis or parakeratosis; 2: mild moderate (MD) severe (SD), carcinoma in situ (CIS).Results: The diagnostic...

Sinonasal mucosal malignant melanoma (SNMMM) is a rare disease. The aim of this study was to investigate the expressions HER4 and CD44 in human SNMMM tissues their relationship with clinicopathological features prognosis patients. In total, 64 paraffin-embedded samples treated our hospital from 29 December 1999 24 June 2011 were collected. detected by immunohistochemistry. differences evaluated matched parameters survival rate, respectively. positive rates 70.3 65.6%, respectively;...

Objective: To expound the clinical effect of a new operation by transplanting double segment triangular fibula flap with vascular pedicle to repair forefoot lateral bone defect, and study how improve method in following stage. Methods: The inclusion criteria: More than 2 phalangeal metatarsal bones defects forefoot, widespread skin soft tissue on pelma dorsal foot, destruction anterior aspect foot arch, which seriously affects function. There was one case application November 2014. repairing...

Objective To investigate the methods and effects of anterolateral thigh flap reconstruction complicated hip decubitus. Methods The study contained 24 cases grade Ⅳ decubitus reconstructed with anterograde pedicled flaps through May 2010 to July 2014. There were 13 males 11 females, aged 26-64 years (mean 54 years). Defects ranged in size from 12 cm×6 cm cm×12 cm. Dimensions harvested 14 cm×8 30 cm×14 Eighteen donor sites directly sutured six covered full thickness...

Objective To study the methods and effects of repairing composite tissue defects hand by transfering posterior tibial artery perforator bone(periosteum) flap.Methods Nine cases traumatic bone soft in underwent digital subtraction angiography (DSA) lower leg preoperatively.According to results anatomical characteristics, nutrient or osteoseptocutaneous vessel was selected as vascular pedicle harvest (periosteum) flap.The osteocutaneous flap transferrede repair defect hand.The volume harvested...

Chemotactic factors,a group of small molecule cytokines in body,can make leucocytes occur chemotactic movement.Belonging to CC family,which is one kind factors,CCL20s are activity-related chemokines. It has been generally considered CCL20 plays a significant role inflammation and immunoreaction.Smoking can cause chronic airway inflammation,irreversible expriatory airflow limitation lung function decline.Even after quit smoking,inflammation obstructive pulmonary disease (COPD) patients'...

Objective To investigate the methods to harvest dorsal forearm flaps when there exists variations of interosseous artery. Methods Variations artery were encountered in 9 cases during retrogredo transfer island flap pedicled on cover soft tissue defect dorsum hand. Several alternative used complete and transfer, including reverse radial branch artery, free posterior flow with proximal as pedicle, perforator based perforators Results Eight survived. Swelling, cyanosis blister distal portion...

Plasminogen activator inhibitor-1 (PAI-1) is one of the members family serine protease inhibitors,is fast,specific,effective physiological inhibitor plasminogen activator,can affect process fibrinolysis involved by tissue-type activator,as well as fibrinolysis,extracellular matrix loops,cell migration,tissue repair,tumor invasion and metastasis urokinasetype under pathological conditions. Key words: Plasminogen inhibitor-1; Pulmonary thromboembolism; Pulmonary fibrosis; Bronchial asthma