A5055657708- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Health, psychology, and well-being
- Neural dynamics and brain function
- Mental Health Research Topics
- Mental Health and Psychiatry
- Phosphodiesterase function and regulation
- Nuclear Receptors and Signaling
- Resilience and Mental Health
- Stress Responses and Cortisol
- Mental Health and Patient Involvement
- Sleep and related disorders
- Psychiatry, Mental Health, Neuroscience
- Alcoholism and Thiamine Deficiency
- Neuroscience and Music Perception
- Advanced MRI Techniques and Applications
- Eicosanoids and Hypertension Pharmacology
- Posttraumatic Stress Disorder Research
- Family Caregiving in Mental Illness
- Nicotinic Acetylcholine Receptors Study
Consorzio Milano Ricerche
2022-2024
Federico II University Hospital
2013-2022
University of Naples Federico II
2014-2021
In this study, we investigated whether minocycline, a second-generation tetracycline proposed as an add-on to antipsychotics in treatment-resistant schizophrenia (TRS), may affect the expression of Homer and Arc postsynaptic density (PSD) transcripts, implicated synaptic regulation. Minocycline was administered alone or with haloperidol rats exposed not ketamine, mimicking acute glutamatergic psychosis naturalistic conditions, respectively. significantly reduced by minocycline compared...
In humans, glucocorticoid excess may cause neuropsychiatric symptoms, including psychosis and cognitive impairment, signaling hyperactivation sensitize to substance of abuse. The aim this work was evaluate whether exposure triggers molecular changes in dopaminergic opioidergic systems within relevant forebrain areas. We acutely exposed Sprague-Dawley rats dexamethasone, a analog, or vehicle evaluated the mRNA expression dopamine D1 D2 receptors enkephalin cortex, striatum, midbrain....
Psychosis has been associated with glucose metabolism impairment. Here, we explored the gene expression of hexokinase 1 (Hk1) and transporter 3 (GLUT3) after administration a subanesthetic or subconvulsant dose ketamine in rats, considered to provide an animal model psychosis. Indeed, Hk1 GLUT3 are crucially involved utilization brain tissues have also implicated pathophysiology Quantitative imaging transcripts was used evaluate mRNA rat regions related ketamine-induced behavioral...
To evaluate the effectiveness of Falloon Psychoeducational Family Intervention (PFI), originally developed for management schizophrenia, afterwards adapted early psychosis, in terms adherence to treatment, low relapse rate, improvement social functioning and stress management.
Managing health care for people suffering from mental illness is undergoing deep changes in recent years Italy. The purpose of this study to describe the progressive process overcoming Forensic Hospitals Italy (OPGs) and identify necessary rehabilitation pathways process, experience territorial service Salerno, Italy.An analysis laws related ongoing an epidemiological structural data referring time interval between 2010 2017 concerning OPGs/Residential Services Execution Security Measures...
Abstract Aim Inte.G.R.O. is a standardized Salutogenic-Psychoeducational intervention designed to help people with severe mental illness manage their life-stress and achieve personal recovery goals through the improvement of social functioning. The aim this study evaluate long-term outcome approach, characterized by health promotion rather than correction dysfunctional strategies. Methods 41 underwent an observational three time-point evaluation (t0, pre- treatment; t1, 12 months; t2, 36...
The covid-19 pandemic/lockdown had a great impact on Severe Mental Illnesses (SMI) the following variables: adherence to protective measures, infection, Covid-related psychopathology, stress related symptoms exacerbation, social relationship loss and higher mortality risk. InteGRO, new effective salutogenic-psychoeducational approach, has been designed help people with SMI manage their life-stress achieve personal recovery goals through improved functioning. Positive outcomes after in...
According to the NMDA-R hypofunction hypothesis of psychosis, administration certain antagonists at NMDA-R, such as ketamine, may exacerbate psychotic symptoms in humans and provide a preclinical model psychosis. Both ketamine antipsychotic drugs induce molecular changes genes post-synaptic density (PSD), involved glutamate signaling dopamine-glutamate interplay. Memantine, an antagonist/partial agonist NMDA-Rs with procognitive properties, has been proposed adjunctive treatment for...
Introduction Psychosocial factors are often underestimated in psychotic patients, although they may profoundly influence (and be influenced by) clinical presentation and effectiveness of therapeutic interventions these people. Objectives To investigate relevance, relationship with overall quality life multiple psychosocial patients. Aims evaluate whether knowledge about the illness utilization health services defective vs. non-psychotic patients correlates type symptoms, cognitive...