A5010628907- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Metabolomics and Mass Spectrometry Studies
- Kruppel-like factors research
- Cancer, Lipids, and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Chemotherapy-induced organ toxicity mitigation
- Problem and Project Based Learning
- Plant-based Medicinal Research
- Radiation Dose and Imaging
- Estrogen and related hormone effects
- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Alcohol Consumption and Health Effects
- Innovative Teaching Methods
- Medicinal Plants and Bioactive Compounds
- Oral health in cancer treatment
- Digestive system and related health
- Traditional Chinese Medicine Studies
- Natural product bioactivities and synthesis
Chengdu Medical College
2020-2024
Gansu University of Traditional Chinese Medicine
2017-2019
With the continuous development of information technology, new teaching resources “micro-video class” and model “flipped classroom” have gradually attracted attention teachers. Whether how they can be applied in pharmacology has already become focus medical education research recent years. This paper explores application evaluation flipped classroom based on micro-video class our college. Students Class 1 2 majoring clinical medicine 2018 Chengdu Medical College were randomly divided into...
Cisplatin (CP) is one of the most effective antitumor drugs in clinic, but has serious adverse reactions, and its hepatotoxicity not been fully investigated. Licorice (GC), a traditional herbal medicine, commonly used as detoxifier for poisons drugs, may be an drug CP-induced hepatotoxicity. However, mechanism effector molecules remain ambiguous. Therefore, this study, network pharmacology proteomics-based approach was established, panoramic view detoxification GC on provided. The...
High intake of phytoestrogen has been reported to be associated with the prevention colorectal cancer (CRC). Calycosin belongs that shown suppress CRC cells in our previous study. However, its anticancer activity and molecular mechanisms have not elucidated. In this study, we analyzed effect calycosin on viability apoptosis human HCT116 SW480 via MTT assay, flow cytometry caspase-3/7 assay. The protein expressions estrogen receptor β (ERβ), PTEN, PI3K/Akt signal pathways were determined by...
Colorectal cancer (CRC) is one of the most common malignancies. Isoliquiritigenin (ISL), a flavonoid phytoestrogen, has shown anti-tumour activities against various cancers. However, its anti-CRC mechanism not been clarified. In this study, potential molecular ISL CRC was investigated through network pharmacological prediction and experimental validation. The results indicate that ESR2, PIK3CG GSK3β might be key targets CRC, which verified by docking, mechanisms related to oestrogen PI3K/AKT...
Alcoholic steatosis is one of the most prevalent forms liver disease, and appropriate insight application anti-steatosis drugs must be considered. Geniposide, major active constituent Gardenia jasminoides (Ellis) fruit, has been commonly used as a traditional herbal medicine for treatment diseases. However, its hepatoprotective effect on alcoholic not reported. Moreover, geniposide overdose-induced hepatotoxicity was demonstrated. Hence, therapeutic effects in rat models along with...
Abstract Functional dyspepsia (FD) is one of the most prevalent functional gastrointestinal disorders, and more multicomponent drugs represented by traditional Chinese medicines have provided a favorable therapeutic effect in its treatment. However, their precise localization clinic, as well corresponding mechanism, ambiguous, thus hindering widespread use. To meet this requirement, systematic approach based on restriction special disease-related molecules following network pharmacology...
Background To explore the value of dual-energy spectral CT in distinguishing solitary pulmonary tuberculosis (SP-TB) from lung adenocarcinoma (S-LUAD). Methods A total 246 patients confirmed SP-TB (n = 86) or S-LUAD 160) were retrospectively included. Spectral parameters include 40keV value, 70keV iodine concentration (IC), water (WC), effective atomic number (Zeff), and curve slope (λ ). Data measured during arterial phase (AP) venous (VP). Chi-square test was used to compare categorical...
5-fluorouracil (5-FU) is one of the most widely used chemotherapy drugs for malignant tumors. However, intestinal mucositis caused by 5-FU a severe dose-limiting toxic effect and even leads to treatment interruption. Isoliquiritigenin (ISL) main active compounds licorice, which traditional Chinese herbal medicine commonly in inflammation gastrointestinal diseases. It speculated that ISL have protective effects on mucositis. no such studies been reported. Therefore, investigate impact...
Noninvasively detecting epidermal growth factor receptor (
Acute blood stasis syndrome was induced in rats by adrenaline hydrochloride and ice water. Ultra performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF/MS) conducted on plasma metabolites of normal model rats. Principal component analysis (PCA), differentiation supervised partial least squares method (PLS-DA), orthogonal to discriminant (OPLS-DA) metabolomics data for multidimensional statistical were employed, the resulting biomarkers screened. Compared...
To filtrate the effective fermentation products of endophytes from Glycyrrhiza uralensis by comparing expectorant effects.Ninety Wistar rats with half males and females were randomly divided into 9 groups(n=10):including normal control group, model positive decoction 5 groups endophytes(JTZB005,JTZB006,JTZB043,JTZB060,JTZB063). The phlegm blocking in lung was induced inhaling SO2 for 30 minutes cold wind 10 twice per day ten days. Ten days later, ml/kg saline administrated group 0.08 mg/kg...