A5038960488- Skin and Cellular Biology Research
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- RNA regulation and disease
- Essential Oils and Antimicrobial Activity
- Silk-based biomaterials and applications
- Wound Healing and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Natural Antidiabetic Agents Studies
- Advanced Glycation End Products research
- Dermatologic Treatments and Research
- Skin Protection and Aging
- Bee Products Chemical Analysis
- Cellular transport and secretion
- CRISPR and Genetic Engineering
- Insect and Pesticide Research
University of Auckland
2016-2024
Abstract Gene therapy based on the CRISPR/Cas9 system has emerged as a promising strategy for treating monogenic fragile skin disorder recessive dystrophic epidermolysis bullosa (RDEB). With this approach problematic wounds could be grafted with gene edited, patient‐specific equivalents. Precise editing using homology‐directed repair (HDR) is ultimate goal, however low efficiencies have hindered progress. Reframing strategies highly efficient non‐homologous end joining (NHEJ) aimed at...
Ma̅nuka honey, made from the nectar of Leptospermum scoparium, has garnered scientific and economical interest due to its nonperoxide antibacterial activity. Biomarkers for genuine ma̅nuka honey are increasingly in demand presence counterfeit honey. This work reports identification a compound previously unreported by HPLC, determination structure as 3,6,7-trimethyllumazine using NMR, MS, IR, UV/vis spectroscopy. assignment was confirmed total synthesis. The natural product, renamed...
One of the key functions human skin is to provide a barrier, protecting body from surrounding environment and maintaining homeostasis internal environment. A mature, stratified epidermis critical achieve barrier function particularly important when producing grafts in vitro for wound treatment. For decades epidermal stratification has been achieved by culturing keratinocytes at an air-liquid interface, triggering proliferating basal differentiate form all layers. We show here that...