TP73 antisense RNA 1 (TP73-AS1), a novel long noncoding (lncRNA), has been suggested to be deregulated in various human cancers and serve as tumor suppressor or promoter, depending on types. The role of TP73-AS1 osteosarcoma is still unknown. In our results, was highly expressed tissue samples cell lines compared with matching adjacent nontumor specimens normal osteoblast line, respectively. Moreover, high expression statistically associated advanced Enneking stage, large size, present...

Sodium benzoate (SB), the sodium salt of benzoic acid, is widely used as a preservative in foods and drinks. The toxicity SB to human body attracted people’s attention due excessive use preservatives increased consumption processed fast modern society. can inhibit growth bacteria, fungi, yeast. However, less known effect on host commensal microbial community compositions their functions. In this study, we investigated development Drosophila melanogaster larvae whether affects We also...

This paper proposes a current balancing loop that is obtained using the threshold median adjustment (TMA-CBL) to achieve accurate of an interleaved constant frequency hysteresis (CFH) buck converter. The CFH control implemented with phase based on width (TWA-FPL). To ensure loop’s stability and minimize steady-state error, multi-phase, coupled, small-signal model (MPC-SSM) derived consideration coupling effect among multiple phases. Furthermore, error analyzed in detail, sensing resistance...

Li-ion battery is becoming the optimal choice for EV's power supply. In order to keep away from charging damage and prolong battery's life, we present evaluate here a special control strategy based on dynamic balanced point along with non-dissipative equalizer. The main focus of proposed insure that individual cell pack will be rapidly, efficiently simultaneously by adjusting equalizing current dynamically. this paper, model four series connected batteries has been established strategy....

This article presents an optimal duty ratio assisted pulse frequency modulation control for very high isolated class E dc–dc converter to achieve both continuous power flow and switch timing. The significantly reduces output ripple of the converter, while timing guarantees consistent zero-voltage-switching (ZVS) minimized reverse conduction loss. To pave way proposed control, a resonant fitting model is established deriving under dynamic switching frequency. calculated according...

Background: Gene therapy of human tumors with adenovirus vectors presents a clinical research challenge and potential opportunity in cancer therapy. One the challenges is that endpoints like tumor reduction, time to recurrence, survival do not provide information about whether therapeutic infects targeted cells or transferred gene functions induces cellular response. Therefore, flow cytometric approach was developed for wildtype, p53 encoding adenoviral vector (Ad-p53) provides (1) relative...

In this paper, a non-probabilistic Chebyshev convex method (CCM) for the transient dynamics of dual-disk rotor system with uncertain parameters is proposed. The dynamic equation derived by finite element (FEM), and deterministic response obtained. Then CCM used to obtain responses system. amplitude ranges characteristics are quite close calculation results Monte Carlo simulation (CMCS), which verifies accuracy validity CCM. experimental demonstrate that proposed has good performance in...

Power losses of switches and inductors are consistent challenges that hinder the development high-frequency power supply in package (PSiP). This paper investigates roadmap for loss optimizations PSiPs. Firstly, a size parallel quantity design method to reduce an integrated Si LDMOSFET is provided with comprehensive consideration switching frequency levels. Secondly, quality factors different air-core analyzed geometric parameters skin effect, which provides winding structure optimization...

This paper proposes a simple but effectual method to alleviate the voltage stress of rectifier and improves overall efficiency conventional PSFB converter. is based on such factor that equivalent circuit converter during oscillation period can be treated as fifth-order model, thus, amplitude ringing across retrain by adjusting value inductor in primary-side. Moreover with this method, it even possible remove RC snubber completely improve efficiency, stresses still limited an acceptable...

The microstructure of alloys is an important factor that affects their application. In this work, the Ag-1.5Cu-1.0Y were prepared by permanent magnet stirring method at different rates. secondary dendrite arm spacing, dendritic segregation, density, microhardness, electrical resistivity, and sulfuration corrosion resistance analyzed to investigate effects rotation speeds on microstructures properties alloy. results showed primary was refined spacing decreased with increase in rate magnets. a...

For very high frequency (VHF) class Φ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> inverter, conventional design method requires complex tuning for parameters. Without fully quantitative calculations, the highly depends on experience that cannot achieve optimal design. In this article, a target function strategy is proposed based harmonic weighting, which simplifies procedures and minimizes switch voltage stress. First, with minimized...

In this paper, a sample voltage dead-beat control based on differentiative prediction (DVP) and switching-cycle extension (SCE) is presented to achieve optimal transient response for DC-DC converters under discontinuous conduction mode (DCM) operation. Firstly, improve load response, DVP method proposed estimate the load. With estimated load, controller realizes current feedforward thus improves with wide range. Secondly, an SCE strategy enlarge output range slew rate, both of which have...

This paper proposes a gallium nitride (GaN)-based very-high-frequency (VHF) resonant flyback converter with integrated magnetics, which utilizes the parasitic inductance and capacitance to reduce passive components count volume of converter. Both primary leakage secondary transformer are utilized as resonance inductor, while power devices is capacitor. An analytical circuit model proposed determine electrical parameters so achieve zero voltage switching (ZVS) current (ZCS). Furthermore, an...

Lithium-ion battery voltage equalization is of great importance to maximize the capacity whole pack and keep cells away from over-charge or over-discharge damage.In this paper, analysis working principle circuit shows that speed lithium-ion can be accelerated with optimized parameters. Look- up table control strategy presented based on circuit. Finally, simulation performed illustrate validity parameters strategy.

Interrupted sampling repeater jamming (ISRJ) is a new type of coherent for wideband radar systems. By copying and repeatedly forwarding the transmitting signal slice by slice, ISRJ can generate series false targets in range direction, which significantly impairs radar's ability to detect track interest. Therefore, an advanced time-frequency (TF) filtering method suppression proposed this paper. Firstly, received echo transformed into TF domain through short-time Fourier transform (STFT)....

Abstract Corner rounding methods have been widely developed to pursue the smooth motions of machine tools. However, most corner methods, which adopt double inscribed transitions, still remain an inherent issue retaining large curvatures transition curves. Even for those circumscribed transitions-based with relatively small curvatures, they also constrain excessively lengths and are limited a low-order continuity, deteriorating feedrate jerk For addressing these problems, C3 continuous (DCCR)...

It has been recently recognized that the DNA sensing innate immune cGAS-STING pathway exerts an IFN-independent antiviral function; however, whether and how chicken STING (chSTING) such activity is still unknown. Here, we showed chSTING in HEK293 cells cells, independent of IFN production. was able to trigger cell apoptosis autophagy independently IFN, inhibitors, rather than could antagonize function chSTING, suggesting involvement function. In addition, lost its IRF7-knockout macrophages,...

For multi-phase voltage regulators (MPVR) with conventional phase shedding and transient clamping (TVC), response is limited by intrinsic error, reduced converter loop feedback delay. To address the issues, this paper proposes differentiation-triggered TVC (DTVC) quasi-zero-delay (QZDPS) schemes for joint enhancement of MPVR. eliminate DTVC scheme adopts a dv/dt circuit to detect output differentiation in advance. Besides, load accelerated saturated drive modulation synchrony current...

Existing current balancing strategy based on single threshold adjustment is not suitable for interleaved constant frequency hysteresis (CFH) buck converter with width (TWA). To address this issue, paper proposes a midpoint (TMA) circuit to achieve balancing. Firstly, comparison in the TWA linearized precisely design loop. Secondly, ensure steady-state accuracy and stability of TMA loop, multi-phase coupled small signal model (MPC-SSM) proposed consideration coupling effect among multiple...