A5052416955- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Renal Transplantation Outcomes and Treatments
- CAR-T cell therapy research
- Transplantation: Methods and Outcomes
- Xenotransplantation and immune response
- Immunodeficiency and Autoimmune Disorders
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Diabetes and associated disorders
- Immunotherapy and Immune Responses
- HIV Research and Treatment
Vall d'Hebron Institut de Recerca
2018-2023
Banc de Sang i Teixits
2017-2023
Universitat Autònoma de Barcelona
2018-2023
CIBBIM-Nanomedicine
2019
Allele-level HLA compatibility in cord blood transplantation has been associated with better transplant outcomes and is recommended as a selection criterion. It also crucial aspect for other therapeutic applications involving blood-derived cells. Determination of high-resolution frequencies an important step towards improving the quality banks. We analyzed HLA-A, -B, -C, -DRB1, -DQB1 allele 5458 high-quality units from Barcelona Cord Blood Bank identified 275 class I 121 II alleles. A*02:01,...
Abstract Aims Cell therapy can be used to repair functionally impaired organs and tissues in humans. Although autologous cells have an immunological advantage, it is difficult obtain high cell numbers for therapy. Well‐characterized banks of with human leukocyte antigens (HLA) that are representative a given population thus needed. The present study investigates the HLA allele haplotype frequencies cohort heart failure (HF) patients. Methods results We carried out typing frequency analysis...
Graves' disease (GD) involves the presence of agonistic auto-antibodies against thyrotropin receptor (TSHR), which are responsible for clinical symptoms. While failure TSHR tolerance is central to GD pathogenesis, process leading this remains poorly understood. Two mechanisms intimately linked have been proposed explain association SNPs located in intron 1 GD: (1) differential alternative splicing thyroid; and (2) modulation expression thymus. To elucidate relative contribution these two we...
HLA‐DQB1*02:102 differs from DQB1*02:01:01 by a single‐nucleotide substitution resulting in an amino acid change.
HLA-B*57:91 differs from HLA-B*57:01:01 by a single nucleotide substitution resulting in an amino acid change.
During the first outbreak of an emergent virus, methods need to be developed rapidly establish suitable therapies for patients with high risk severe disease caused by pathogen. Considering importance T-cell response in controlling viral infections, adoptive cell therapy virus-specific T cells has been used as a safe and effective antiviral prophylaxis treatment immunocompromised patients. The main objective this study was method cryostore whole blood starting material adapt activation...