A5066017784- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Inflammatory Bowel Disease
- Digestive system and related health
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Liver Disease Diagnosis and Treatment
- Animal Virus Infections Studies
- Pancreatitis Pathology and Treatment
- Microscopic Colitis
- NF-κB Signaling Pathways
- Inflammasome and immune disorders
- Immune cells in cancer
- Dermatology and Skin Diseases
- CAR-T cell therapy research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Cells and Metastasis
- SARS-CoV-2 and COVID-19 Research
- Diet, Metabolism, and Disease
- IL-33, ST2, and ILC Pathways
- Pancreatic and Hepatic Oncology Research
- Plant Virus Research Studies
- Polyomavirus and related diseases
- Virus-based gene therapy research
Universitat Autònoma de Barcelona
2023-2024
Banc de Sang i Teixits
2023-2024
Vall d'Hebron Institut de Recerca
2023-2024
Massachusetts General Hospital
2019-2023
Harvard University
2019-2023
Moscow Research and Clinical Center for Neuropsychiatry
2020
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2012-2016
Hospital Clínic de Barcelona
2012-2016
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2015-2016
Centro de Investigación Biomédica en Red
2012
<h3>Objective</h3> Ulcerative colitis (UC) is a chronic condition characterised by the relapsing inflammation despite previous endoscopic and histological healing. Our objective was to identify molecular signature associated with UC remission. <h3>Design</h3> We performed whole-genome transcriptional analysis of colonic biopsies from patients histologically active inactive UC, non-inflammatory bowel disease (non-IBD) controls. Real-time reverse transcriptase-PCR immunostaining were used for...
Objective UC is a chronic inflammatory disease of the colonic mucosa. Growing evidence supports role for epithelial cell defects in driving pathology. Moreover, long-lasting changes barrier have been reported quiescent UC. Our aim was to investigate whether could originate from compartment imprinted by disease. Design Epithelial organoid cultures (EpOCs) were expanded ex vivo intestinal crypts non-IBD controls and patients with EpOCs induced differentiate (d-EpOCs), total RNA extracted...
Some naïve T cell fates are sealed Tissue-resident memory (T RM ) cells constitute a subpopulation of that reside in tissues instead recirculating. CD8 + epithelial TRM (eT cells, which occupy the epithelium sites like skin, require transforming growth factor–β (TGF-β) for their development. Mani et al. found α V integrin–expressing dendritic activate and present TGF-β, key (see Perspective by Farber). Surprisingly, this interplay did not occur skin or draining lymph nodes during priming....
CD8+ tissue-resident memory T cells (TRM) persist at sites of previous infection, where they provide rapid local protection against pathogen challenge. TRM expressing the α1 chain (CD49a) integrin VLA-1 have been identified within resolved skin infection and in vitiligo lesions. We demonstrate that CD49a is expressed early following cell activation vivo, TGF-β IL-12 induce expression by vitro. Despite this expression, not required for generation a primary response to cutaneous herpes simplex...
Crohn's disease (CD) has been associated with an altered immune response to commensal microbiota, mostly based on increased seroreactivity microbial proteins. Although T cells are believed contribute the development of CD, little is known about antigens involved. We investigated antigen-specificity isolated from patients CD.We peripheral blood mononuclear 65 CD and 45 healthy individuals (controls). T-cell reactivity using proliferation assays (based thymidine incorporation...
Ulcerative colitis (UC) is a chronic intestinal inflammatory disease that may undergo periods of activity followed by remission. We aimed to identify the endogenous regulatory mechanisms promote Transcriptional and protein analysis mucosa revealed IL-1 decoy receptor, interleukin-1 receptor type 2 (IL1R2), was upregulated in remission compared with active UC controls. identified epithelial cells as being responsible for increased IL-1R2 production during Expression IL1R2 negatively regulated...
Excessive fibroblast expansion and extracellular matrix (ECM) deposition are key events for the development of bowel stenosis in Crohn's disease (CD) patients. Tocotrienols vitamin E compounds with proven vitro antifibrogenic effects on rat pancreatic fibroblasts. We aimed at investigating tocotrienols human intestinal (HIF) proliferation, apoptosis, autophagy, synthesis ECM.HIF isolated from CD, ulcerative colitis (UC), normal intestine were treated tocotrienol-rich fraction (TRF) palm oil....
ABSTRACT BK polyomavirus infection is an important cause of graft loss in transplant patients, however, currently available therapies lack effectiveness against this pathogen. Identification immunological targets for potential treatments therefore necessary. The aim study was to predict candidates immunodominant epitopes within four virus proteins (VP1, VP2, VP3 and LTA) using PBMCs from 44 healthy donors. We used the ELISpot epitope mapping method evaluate T‐cell response, HLA‐peptide...
During the first outbreak of an emergent virus, methods need to be developed rapidly establish suitable therapies for patients with high risk severe disease caused by pathogen. Considering importance T-cell response in controlling viral infections, adoptive cell therapy virus-specific T cells has been used as a safe and effective antiviral prophylaxis treatment immunocompromised patients. The main objective this study was method cryostore whole blood starting material adapt activation...
Abstract Tissue resident memory CD8+ T cells (TRM) persist long-term in lymphoid and non-lymphoid tissues to provide rapid, local defense against pathogens tumors. cytokines drive the formation persistence of TRM. However, whether microenvironment can inhibit TRM is largely unknown. Individuals suffering from conditions associated with helper 2 (Th2)-type immune responses, such as atopic dermatitis, asthma, some cancers, present impaired anti-viral or anti-tumor responses. We hypothesize...
Abstract Resident memory CD8+ T cells (TRM) persist at sites of previous infection where they provide rapid local protection against pathogen challenge. TRM expressing the a1 chain (CD49a) integrin VLA-1 have been identified within resolved skin as well in vitiligo lesions. This study examines signals that regulate cell CD49a expression and its requirement for cutaneous formation response. We demonstrate was expressed early following activation vivo, TGF-b IL-12 induced by vitro. Despite...