A5049218852- Immune Cell Function and Interaction
- Invertebrate Immune Response Mechanisms
- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- Immunotherapy and Immune Responses
- Neurobiology and Insect Physiology Research
- Dermatology and Skin Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant-Microbe Interactions and Immunity
- Immune cells in cancer
- Insect symbiosis and bacterial influences
- Mosquito-borne diseases and control
Boston University
2024-2025
Massachusetts General Hospital
2019-2020
Harvard University
2020
Some naïve T cell fates are sealed Tissue-resident memory (T RM ) cells constitute a subpopulation of that reside in tissues instead recirculating. CD8 + epithelial TRM (eT cells, which occupy the epithelium sites like skin, require transforming growth factor–β (TGF-β) for their development. Mani et al. found α V integrin–expressing dendritic activate and present TGF-β, key (see Perspective by Farber). Surprisingly, this interplay did not occur skin or draining lymph nodes during priming....
CD8+ tissue-resident memory T cells (TRM) persist at sites of previous infection, where they provide rapid local protection against pathogen challenge. TRM expressing the α1 chain (CD49a) integrin VLA-1 have been identified within resolved skin infection and in vitiligo lesions. We demonstrate that CD49a is expressed early following cell activation vivo, TGF-β IL-12 induce expression by vitro. Despite this expression, not required for generation a primary response to cutaneous herpes simplex...
The death and clearance of nurse cells is a consequential milestone in Drosophila melanogaster oogenesis. In preparation for oviposition, the germline-derived bequeath to developing oocyte all their cytoplasmic contents undergo programmed cell death. controlled non-autonomously precipitated by epithelial follicle somatic origin acquiring squamous morphology acidifying externally. Alternatively, stressors such as starvation can induce earlier mid-oogenesis, manifesting apoptosis signatures,...
Abstract The death and clearance of nurse cells is a consequential milestone in Drosophila melanogaster oogenesis. In preparation for oviposition, the germline-derived bequeath to developing oocyte all their cytoplasmic contents undergo programmed cell death. controlled non-autonomously precipitated by epithelial follicle somatic origin acquiring squamous morphology acidifying externally. Alternatively, stressors such as starvation can induce earlier mid-oogenesis, manifesting apoptosis...
Cell death is an important process in the body, as it occurs throughout every tissue during development, disease, and regeneration. Phagocytes are responsible for clearing away dying cells typically characterized either professional or nonprofessional phagocytes. Professional phagocytes, such macrophages, found nearly part of body while epithelial cells, type. However, there organs that considered “immune-privileged” they have little to no immune surveillance rely on phagocytes engulf cells....
Abstract Tissue resident memory CD8+ T cells (TRM) persist long-term in lymphoid and non-lymphoid tissues to provide rapid, local defense against pathogens tumors. cytokines drive the formation persistence of TRM. However, whether microenvironment can inhibit TRM is largely unknown. Individuals suffering from conditions associated with helper 2 (Th2)-type immune responses, such as atopic dermatitis, asthma, some cancers, present impaired anti-viral or anti-tumor responses. We hypothesize...
Abstract Resident memory CD8+ T cells (TRM) persist at sites of previous infection where they provide rapid local protection against pathogen challenge. TRM expressing the a1 chain (CD49a) integrin VLA-1 have been identified within resolved skin as well in vitiligo lesions. This study examines signals that regulate cell CD49a expression and its requirement for cutaneous formation response. We demonstrate was expressed early following activation vivo, TGF-b IL-12 induced by vitro. Despite...