A5108058814- Nuclear Engineering Thermal-Hydraulics
- Nuclear reactor physics and engineering
- Nuclear Materials and Properties
- Pluripotent Stem Cells Research
- Risk and Safety Analysis
- CRISPR and Genetic Engineering
- Fault Detection and Control Systems
- 3D Printing in Biomedical Research
- Graphite, nuclear technology, radiation studies
- Heat Transfer and Boiling Studies
- Neuroscience and Neural Engineering
- Fluid Dynamics Simulations and Interactions
- Advanced Data Processing Techniques
- Mesenchymal stem cell research
- Fluid Dynamics and Mixing
- Probabilistic and Robust Engineering Design
- Cancer and Skin Lesions
- Heavy Metal Exposure and Toxicity
- Birth, Development, and Health
- Neurogenesis and neuroplasticity mechanisms
- Fluid Dynamics and Heat Transfer
- Marine and Coastal Research
- earthquake and tectonic studies
- Advanced Energy Technologies and Civil Engineering Innovations
- RNA Interference and Gene Delivery
Yueyang Hospital
2025
Shanghai University of Traditional Chinese Medicine
2025
China General Nuclear Power Corporation (China)
2021-2024
Shanghai Jiao Tong University
2023
The University of Texas at San Antonio
2020
The University of Texas Health Science Center at Houston
2017-2020
Design Science (United Kingdom)
2019
The University of Texas Health Science Center at San Antonio
2012-2019
South Texas Veterans Health Care System
2012-2015
Geriatric Research Education and Clinical Center
2012-2013
The skin is susceptible to different injuries and diseases. One major obstacle in tissue engineering how develop functional three-dimensional (3D) substitute for damaged skin. Previous studies have proved a 3D dynamic simulated microgravity (SMG) culture system as "stimulatory" environment the proliferation differentiation of stem cells. Here, we employed NASA-approved rotary bioreactor investigate human epidermal cells (hEpSCs). hEpSCs were isolated from children foreskins enriched by...
Intranasal administration is a promising route of delivery stem cells to the central nervous system (CNS). Reports on this mode cell have not yet focused across cribriform plate by which move from nasal cavity into CNS. In current experiments, human mesenchymal (MSCs) were isolated Wharton’s jelly umbilical cords and labeled with extremely bright quantum dots (QDs) in order track efficiently. At 2 h after intranasal immunodeficient mice, found under olfactory epithelium, crossing adjacent...
Estrogen dysregulation causes hair disorder. Clinical observations have demonstrated that estrogen raises the telogen/anagen ratio and inhibits shaft elongation of female scalp follicles. In spite these clinical insights, properties on follicles are poorly dissected. present study, we show induced apoptosis precortex cells caused premature catagen by up-regulation TGF β2. Immediately after catagen, expression anagen chalone BMP4 increased. The may further function to prevent transition...
Antibody class-switch DNA recombination (CSR) is initiated by AID-introduced DSBs in the switch (S) regions targeted for recombination, as effected Ku70/Ku86-mediated NHEJ. Ku-deficient B cells, however, undergo (reduced) CSR through an alternative(A)-NHEJ pathway, which introduces microhomologies S-S junctions. As microhomology-mediated end-joining requires annealing of single-strand ends, we addressed contribution factors HR Rad52 and translesion polymerase θ to CSR. Compared with their...
Among the various species from which induced pluripotent stem cells have been derived, nonhuman primates (NHPs) a unique role as preclinical models. Their relatedness to humans and similar physiology, including central nervous system, make them ideal for translational studies. We review here progress made in deriving characterizing iPS cell lines different NHP species. focus on marmoset, small several human disease states can be modeled. The marmoset serve model implementation of...
Estrogen contributes to females' strong antibody response microbial vaccines and proneness autoimmunity, particularly antibody-mediated systemic in females. We have hypothesized that this is due estrogen-mediated potentiation of class switch DNA recombination (CSR) somatic hypermutation (SHM). As we shown, estrogen boosts AID expression, which critical for both CSR SHM, through upregulation HoxC4, together with NF-κB critically mediates
Type 1 diabetes mellitus, characterized by loss of pancreatic beta-cells, can be ameliorated islet transplantation, but this treatment is restricted the scarcity tissue and allograft rejection.We isolated skin-derived precursors (SKPs)--an abundant source autologous cells--and developed an experimental strategy to convert them into insulin-producing cells (IPCs) in vitro within a short period time, through extracellular factor modification analyses IPCs reverse transcription-polymerase chain...
Introduction: The accurate prognosis of reactor accidents is essential for deploying effective strategies that prevent radioactive releases. However, research in the nuclear sector limited. This paper introduces a novel Temporal Fusion Transformer (TFT) model-based method accident incorporates multi-headed self-attention and gating mechanisms. Methods: Our proposed combines mechanisms TFT with multiple covariates to enhance prediction accuracy. Additionally, we employ quantile regression...
The marmoset is an important nonhuman primate model for regenerative medicine. For experimental autologous cell therapy based on induced pluripotent (iPS) cells in the marmoset, must be able to undergo robust and reliable directed differentiation that will not require customization each specific iPS clone. When were aggregated a hanging drop format 3 days, followed by exposure dual SMAD inhibitors retinoic acid monolayer culture we found substantial variability response of different clones....
Cell transplantation-based therapy could be an effective way for the treatment of many diseases. Among numerous somatic stem cells isolated and purified, skin-derived precursors (SKPs) are abundant autologous cells, providing a large reservoir therapeutic transplantation. Previous studies showed that SKPs differentiated into neural mesodermal progeny in vitro. In present study, we attempted to differentiate muscle progenitors After with combination growth factors, were expressing markers...
Induced pluripotent stem cells (iPS cells) are important for the future development of regenerative medicine involving autologous cell therapy. Before therapy can be applied to human patients, suitable animal models must developed, and in this context non-human primate critical. We previously characterized several lines marmoset iPS derived from newborn skin fibroblasts. In present studies, we explored methods directed differentiation neuroectodermal lineage. process used an iterative which...