A5101967449- Fibromyalgia and Chronic Fatigue Syndrome Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Connective tissue disorders research
- Autophagy in Disease and Therapy
- Reproductive tract infections research
- Myofascial pain diagnosis and treatment
- Aortic aneurysm repair treatments
- Musculoskeletal pain and rehabilitation
- Coronary Interventions and Diagnostics
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Urinary Tract Infections Management
- Adipose Tissue and Metabolism
- Elasticity and Material Modeling
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Electric Power System Optimization
- ATP Synthase and ATPases Research
- Toxin Mechanisms and Immunotoxins
The University of Texas Health Science Center at San Antonio
2011-2025
The University of Texas Health Science Center at Houston
2006-2025
Yueyang Hospital
2025
Shanghai University of Traditional Chinese Medicine
2025
North China Electric Power University
2023
The University of Texas at San Antonio
2009-2022
Huazhong University of Science and Technology
2017
Tongji Hospital
2017
Audie L. Murphy Memorial VA Hospital
2017
Loudi Central Hospital
2013-2015
Highlights•Expression of Aire and self-antigen genes decreases with age in thymic B cells•B cell-intrinsic cell-extrinsic mechanisms contribute to this decline expression•The phenotype transcriptome cells change age•T-bet expression frequency IgG2a increase aged cellsSummaryAlthough autoimmune disorders are a significant source morbidity mortality older individuals, the governing age-associated increases susceptibility remain incompletely understood. Central T cell tolerance is mediated...
Both anti- and proapoptotic activities have been reported to occur during chlamydial infection. To reconcile the apparent controversy, we compared host cell apoptotic responses infection with 17 different serovars strains. None of caused any biologically significant apoptosis in infected cells. Host cells chlamydia-infected cultures can continue undergo DNA synthesis mitosis. Chlamydia-infected are resistant induction, although extent antiapoptotic ability varied between serovars. These...
We have previously correlated Chlamydia trachomatis antiapoptotic activity with the blockade of mitochondrial cytochrome c release and inhibition Bax Bak activation. now report that C. infection leads to degradation Bik, Puma, Bim, three upstream proapoptotic BH3-only proteins Bcl-2 family can transmit death signals mitochondria by inhibiting and/or activating members, such as Bak. This observation has provided new information on chlamydial antiapoptosis mechanisms.
The aberrant expression of microRNAs (miRNAs/miRs) has been found in numerous cancer types. miR-32 is an oncomiR prostate (PCa), however, the mechanisms by which functions as a regulator radiotherapy response and resistance PCa are largely unknown. In present study, it was that DAB2 interacting protein (DAB2IP), miR-32-dependent tumor-suppressor gene, downregulated induced autophagy inhibited radiotherapy-induced apoptosis cells. upregulated or overexpressed PCa, DAB2IP through direct...
We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. now report activation of both Bax Bak, two proapoptotic members the Bcl-2 family regulate release, was inhibited in chlamydia-infected cells. This observation has provided new information on mechanisms chlamydial antiapoptotic activity.
Avaliar os efeitos do treinamento aeróbico e alongamento sobre níveis séricos de serotonina (5-HT) seu principal metabólito ácido 5-hidroxiindolacético (5-HIAA). Foram randomizadas 22 mulheres com fibromialgia (FM) em uma duas modalidades exercício (exercício caminhada ou alongamento) a serem rea- lizadas três vezes por semana, 20 semanas. Os 5-HT 5-HIAA foram avaliados antes após o programa exercícios cromatografia líquida alta eficiência (CLAE) detecção colorimétrica. A análise grupo...
Objective. To determine the genotype frequencies of ß 2 -adrenergic receptor (ß AR) gene polymorphisms (Gly16Arg, Glu27Gln) in patients with fibromyalgia syndrome (FM) by comparison unrelated healthy controls. We sought any clinical association these and determined whether would associate a biologic guanosine protein-coupled stimulator (Gs) dysfunction FM. Methods. Study subjects included 97 clinically characterized FM 59 The AR at codons 16 27 were using polymerase chain...
Abstract Chlamydia trachomatis, an obligate intracellular bacterial species, is known to inhibit host cell apoptosis. However, the chlamydial antiapoptotic mechanism still not clear. Because NF-κB activation antiapoptotic, we tested potential role of in activity current study. First, no obvious was detected chlamydia-infected cells when these were resistant apoptosis induced via either intrinsic or extrinsic pathways. Second, inhibition with pharmacologic reagents failed block activity....
Thymic atrophy reduces naive T cell production and contributes to increased susceptibility viral infection with age. Expression of tissue-restricted antigen (TRA) genes also declines age has been thought increase autoimmune disease susceptibility. We find that diminished expression a model TRA gene in aged thymic stromal cells correlates impaired clonal deletion cognate recognizing an autoantigen involved atherosclerosis. Clonal the polyclonal thymocyte population is perturbed. Distinct...
Thymic stromal cells (TSCs) are critical regulators of T cell tolerance, but their basic biology has remained under-characterized because they relatively rare and difficult to isolate. Recent work revealed that constitutive autophagy in TSCs is required for self-antigen presentation central tolerance induction; however, the mechanisms regulating not well understood. Hydrogen peroxide been shown increase flux other tissues, we previously identified conspicuously low expression hydrogen...
Tortuous carotid arteries are often seen in aged populations and associated with atherosclerosis, but the underlying mechanisms to explain this preference unclear. Artery buckling has been suggested as one potential mechanism for development of tortuous arteries. The objective study, accordingly, was determine effect on cell proliferation NF-κB activation We developed a technique generate porcine using long artery segments organ culture without changing pressure, flow rate, axial stretch...
HMGB1, which acts as a DNA chaperone to help maintain nuclear homeostasis, was reported play prominent role in cancer progression, angiogenesis, invasion, and metastasis development. Increased expression of HMGB1 has been observed several tumor entities. However, the molecular mechanisms tumorigenesis bladder have rarely reported. In present study, real-time quantitative RT-PCR analysis revealed that human urothelial carcinoma (BUC) cells much higher than normal urethra epithelial cells....
To evaluate the effects of aerobic training and stretching on serum levels serotonin (5HT) its main metabolite 5-hydroxindolacetic acid (5HIAA). Twenty-two women with FM were randomized into one two exercise modalities (aero- bic walking or exercise) to be accomplished three times a week for 20 weeks. The 5HT 5HIAA evaluated before after program by high performance liquid chromatography (HPLC) colorimetric detection. Within group analysis (pre-post) showed that both changed significantly in...
Adiponectin is a multifunctional adipokine that has several oligomeric forms in the blood stream, which broadly regulates innate and acquired immunity. Therefore, this study, we aimed to observe differentiation of T helper (Th) cells expression costimulatory signaling molecules affected by adiponectin. The mRNA protein levels adiponectin its receptors oxidized low density lipoprotein cholesterol-treated endothelial were assayed real time PCR immunofluorescence. then treated with or without...