A5056461124- Neonatal and fetal brain pathology
- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Meningioma and schwannoma management
- Infant Development and Preterm Care
- Fetal and Pediatric Neurological Disorders
- Cerebrospinal fluid and hydrocephalus
- Parkinson's Disease Mechanisms and Treatments
- Traumatic Brain Injury Research
- Advanced Neuroimaging Techniques and Applications
- Neonatal Respiratory Health Research
- Genetic Neurodegenerative Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Hypoxia, and Metabolism
- Advanced MRI Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Sleep and related disorders
- Spinal Dysraphism and Malformations
- Hedgehog Signaling Pathway Studies
- Soft Robotics and Applications
- Brain Metastases and Treatment
- Cancer Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Atomic and Subatomic Physics Research
- Botulinum Toxin and Related Neurological Disorders
University Hospital Dubrava
2017-2024
Catholic University of Croatia
2022-2024
University of Zagreb
2014-2022
Winthrop-University Hospital
2018
University Hospital Centre Zagreb
2013
The cerebral wall of the human fetal brain is composed transient cellular compartments, which show characteristic spatiotemporal relationships with intensity major neurogenic events (cell proliferation, migration, axonal growth, dendritic differentiation, synaptogenesis, cell death, and myelination). aim present study was to obtain new quantitative data describing volume, surface area, thickness compartments in cerebrum. Forty-four postmortem brains aged 13-40 postconceptional weeks (PCW)...
In this study, we aimed to identify major fiber pathways and their spatiotemporal relationships within transient fetal zones in the human brain by comparing postmortem high-angular resolution diffusion MR imaging (HARDI) combination with deterministic streamline tractography histology. Diffusion weighted was performed on brains [N = 9, age 18-34 post-conceptual weeks (PCW)] that were grossly normal no pathologic abnormalities. After HARDI performed, fibers reconstructed using Q-ball...
Disorders of consciousness (DoC), namely unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), represent severe conditions with significant consequences for patients their families. Several studies have reported the regaining in such using deep brain stimulation (DBS) subcortical structures or brainstem nuclei. Our study aims to present 10 years' experience a single center DBS as therapy on cohort DoC. Eighty Three consecutive were evaluated between 2011 2022; entry...
Background Cranial vault lymphomas (CVLs) are rare skull lesions, mostly caused by diffuse large B-cell lymphoma, a subtype of non-Hodgkin lymphoma (NHL). Chronic lymphocytic leukemia/small (CLL/SLL) extremely rarely causes cranial lesions. Herein, we report case CLL/SLL causing unique and extensive lesion with striking presentation helmet-shaped tumor, whose treatment ibrutinib led to full bone regeneration. Case Description A 63-year-old woman was admitted our hospital for the continuation...
Abstract Disorders of consciousness (DOC) are one the major consequences after anoxic or traumatic brain injury. So far, several studies have described regaining in DOC patients using deep stimulation (DBS). However, these often lack detailed data on structural and functional cerebral changes such treatment. The aim this study was to conduct a volumetric analysis specific cortical subcortical structures determine impact DBS recovery patients. Five underwent unilateral electrode implantation...
The aim of this study was to determine, by immunohistochemical methods, the expression nEGFR and markers cell proliferation (Ki-67), cycle (mEGFR, p53, cyclin D1), tumor stem cells (ABCG2) in 59 pathohistological samples healthy oral mucosa, 50 premalignant changes (leukoplakia erythroplakia), 52 squamous carcinomas (OSCC). An increase mEGFR found with development disease (p < 0.0001). In group patients leukoplakia erythroplakia, we a positive correlation between Ki67, D1, mEGFR, whereas...
Abstract Background We present a novel robotic neuronavigation system (RONNA G4), used for precise preoperative planning and frameless neuronavigation, developed by research group from the University of Zagreb neurosurgeons Hospital Dubrava, Zagreb, Croatia. The aim study is to provide comprehensive error measurement analysis brain biopsy. Methods Frameless stereotactic robot‐assisted biopsies were performed on 32 consecutive patients. Post‐operative CT MRI scans assessed precisely measure...
Epithelial to mesenchymal transition (EMT), which is characterized by the reduced expression of E-cadherin and increased N-cadherin, plays an important role in tumor invasion metastasis. Classical Wnt signaling pathway has a tight link with EMT it been shown that nuclear translocation β-catenin can induce EMT. This research showed genes are involved cadherin switch, CDH1 CDH2, play meningioma progression. Increased N-cadherin relation was recorded. In meningioma, transcription factors SNAIL,...
Introduction : Primary intracranial teratoma is a subtype of germ cell tumors, classified into three subtypes. They occur very rarely, with only several reported individual cases in adults. Case Description We present patient an intermittent headache the right frontal region. Magnetic resonance imaging (MRI) revealed sided high parasagittal mass that compressed falx, lateral ventricle, as well brain parenchyma. Patient underwent surgical treatment. Histopathological analysis described mature...
Abstract Mucoepidermoid carcinoma, a salivary gland tumor, rarely occurs in bronchial mucous glands. Brain metastases are seen which makes for challenging diagnosis and treatment approach. A 40-year-old woman presented with confusion, ataxia, accompanied by declining Glasgow Coma Score. computerized tomography revealed two hyperdense, postcontrast-enhanced infra- supratentorial lesions perifocal edema. First causing obstructive hydrocephalus. The initial surgery involved external ventricular...
Cognitive deficits after perinatal brain lesion in preterm infants are among the most common neurodevelopmental disturbances. The relationship between structural changes on at term magnetic resonance imaging (MRI) and cognitive preschool age should be a special focus due to timely intervention. aim of this study was correlate qualitative quantitative MRI parameters children, early neonatal follow up MRI, with general specific functions age. Twenty-one verified lesions based clinical...
Dystonia is the third most common pediatric movement disorder and often difficult to treat. Deep brain stimulation (DBS) of internal pallidum (GPi) has been demonstrated as a safe effective treatment for genetic dystonia in adolescents adults. The results DBS children are limited individual cases or case series, although it proven be an procedure carefully selected cohorts. aim our study was present outcome 7- 9-year-old patients with disabling monogenic isolated generalized DYT-THAP1...
The aim of this study was to perform for the first time intracranial volumetric analysis cerebrospinal fluid (CSF) and brain parenchyma in supratentorial infratentorial space a 30-year-old female patient with hydranencephaly macrocephaly. A head scan performed using 3T magnetic resonance followed by manual segmentation CSF on T2 coronal sections. volume measured separately space. total 3645.5 cm3. In space, 3375.2 cm3 80.3 101.3 88.7 there severe malacia almost all no visible remnants...
Preterm birth is associated with a wide range of adverse developmental outcomes, including sensory, motor, cognitive and language impairments, behavioral or attention problems. Subtle motor deficits that might emerge in premature infants no evident mild brain injury encompass qualitative quantitative aspects behavior. This prospective cohort study provided an evaluation the relationship between tissue volumes revealed by magnetic resonance imaging (MRI) at term-equivalent age behavior...
Primary central nervous system lymphoma and its subtype, primary dural lymphoma, are types of non-Hodgkin's that only occur in the without any dissemination. They extremely rare cases extra nodal lymphomas accounting for 1--5% intracranial tumors.We present a patient diagnosed with right frontal brain region who underwent surgical resection. Histopathological analysis revealed diffuse B-type large cell non-Hodgkin lymphoma. Patient four cycles R-CHOP intrathecal methotrexate protocol. Six...
Abstract Background The purpose of this study was to investigate the expression nuclear EGFR (nEGFR) and stem cell marker ABCG2 in oral leukoplakia (OL) erythroplakia (OE) assess their significance as prognostic biomarkers for malignant transformation. Methods In we included 50 patients with potentially disorders (OPMD), 31 OL 19 OE, whom examined nEGFR by immunohistochemical methods. Results Twenty‐one (42%) OE developed squamous carcinoma (OSCC). transformation increased 12,84‐fold (95%...