A5026953153- Lipid metabolism and biosynthesis
- Mechanisms of cancer metastasis
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Sleep and Wakefulness Research
- Metabolomics and Mass Spectrometry Studies
- Genetics, Aging, and Longevity in Model Organisms
- Metalloenzymes and iron-sulfur proteins
- Angiogenesis and VEGF in Cancer
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Enzyme Structure and Function
Albert Einstein College of Medicine
2018-2023
Yeshiva University
2018-2020
In search of redox mechanisms in breast cancer, we uncovered a striking role for glutathione peroxidase 2 (GPx2) oncogenic signaling and patient survival. GPx2 loss stimulates malignant progression due to reactive oxygen species/hypoxia inducible factor-α (HIF1α)/VEGFA (vascular endothelial growth factor A) signaling, causing poor perfusion hypoxia, which were reversed by reexpression or HIF1α inhibition. Ingenuity Pathway Analysis revealed link between loss, tumor angiogenesis, metabolic...
Storage of triglycerides in lipid droplets is governed by a set droplet-associated proteins. One these proteins, hypoxia-inducible (HILPDA), was found to impair droplet breakdown macrophages and cancer cells inhibiting adipose triglyceride lipase. Here, we aimed better characterize the role mechanism action HILPDA hepatocytes. We performed studies HILPDA-deficient HILPDA-overexpressing liver cells, slices, mice. The functional physical interactions were investigated using variety biochemical...
Abstract Fasting triggers diverse physiological adaptations including increases in circulating fatty acids and mitochondrial respiration to facilitate organismal survival. The mechanisms driving respiratory sufficiency during fasting remain incompletely understood. Here we show that or lipid availability stimulates mTORC2 activity. Activation of phosphorylation its downstream target NDRG1 at serine 336 sustains fission sufficiency. Time-lapse imaging shows NDRG1, but not the...
ABSTRACT Lipid droplets (LD) are dynamic organelles that can expand and shrink, driven by fluctuations in the rate of triglyceride synthesis degradation. Triglyceride synthesis, storage LD, degradation governed a complex set LD-associated proteins. One these proteins, hypoxia-inducible lipid droplet-associated (HILPDA), was found to impair LD breakdown inhibiting adipose lipase. Here we characterized physiological role mechanism action HILPDA hepatocytes. Expression induced fatty acids...
Mechanistic target of rapamycin (mTOR) senses amino acids; however, its role in lipid metabolism is less established. Organismal requirements are largely met through dietary intake. How nutrient sensing mechanisms gut interface with fat remains unclear. Here we reveal fundamental and cooperative roles for mTOR complexes 1 2 (mTORC1/2) absorption triglycerides. Dietary activates mTORC1/2 signaling gut. Hyperactivating mTORC1 by deleting Tsc1 sufficient to promote triglyceride metabolic...
Lipid droplets (LD) are dynamic organelles that can expand and shrink, driven by fluctuations in the rate of triglyceride synthesis degradation. Triglyceride synthesis, storage LD, degradation governed a complex set LD-associated proteins. One these proteins, hypoxia-inducible lipid droplet-associated (HILPDA), was found to impair LD breakdown inhibiting adipose lipase. Here we characterized physiological role mechanism action HILPDA hepatocytes. Expression induced fatty acids several...
Summary Fasting triggers diverse cellular and metabolic adaptations to facilitate organismal survival 1,2 . During nutrient deprivation, increases in circulating fatty acids support mitochondrial respiration 2 The mechanisms driving respiratory sufficiency during deprivation remain incompletely understood. Here we show that extended periods of fasting, or lipid availability stimulates mTORC2 activity. Activation phosphorylation its target NDRG1 3 at S336 sustains fission sufficiency....