A5032222110- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Cancer therapeutics and mechanisms
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Cholinesterase and Neurodegenerative Diseases
- Atherosclerosis and Cardiovascular Diseases
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Receptor Mechanisms and Signaling
- Hypothalamic control of reproductive hormones
- Phenothiazines and Benzothiazines Synthesis and Activities
- Monoclonal and Polyclonal Antibodies Research
- Drug Transport and Resistance Mechanisms
- Plant Pathogenic Bacteria Studies
- Aquaculture disease management and microbiota
- Phytoplasmas and Hemiptera pathogens
- Protein Interaction Studies and Fluorescence Analysis
- Synthesis and Reactivity of Heterocycles
- Microbial Metabolism and Applications
- Chromatography in Natural Products
- Bacteriophages and microbial interactions
- Machine Learning in Bioinformatics
D.Y. Patil University
2022-2024
Ajeenkya DY Patil University
2022-2024
International Centre for Genetic Engineering and Biotechnology
2017-2022
National Institute for Research in Reproductive Health
2020-2021
Bharathiar University
2013-2019
The newly synthesized hetero annulated carbazoles were prepared in good yields and structurally characterized by all spectral means. vitro cytotoxicity was evaluated for the compounds MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against HeLa MCF 7 compared with standard drug ellipticine. Compound 5b outperformed All showed moderate to potent activity cell lines. preliminary structure–activity relationships carried out. In order understand nature of interactions...
Aims: Rhizophora apiculata is a traditional medicine used to treat pain, ulcer, and inflammation in southeast coast of India without scientific evidence. Therefore, we aimed evaluate antinociceptive effect R. chemical thermal induced nociceptive models. Place Duration Study: Centre Advanced Study Marine Biology, Faculty Sciences, Annamalai University, Parangipettai, Tamil Nadu, India, between June 2012 September 2012. Methodology: Albino mice received 10, 15, 20, or 25 mg/kg alkaline...
A series of novel cyclopent[b]indole analogues that hold isoxazolo-, pyrido-templates were designed and synthesized in good yields. The vitro cytotoxicity was concerned for all the newly compounds by MTT assay against HeLa (cervix adeno carcinoma) MCF-7 (breast cancer). These further compared with standard drug ellipticine, 5-fluorouracil, cisplatin, methotrexate. heteroannulated found to show better cytotoxic activity primary structure relationship studies. To identify nature interactions...
An attempted synthesis of 5-aryl-6,7-dihydrodibenzo[b,j][1,10]phenanthroline derivatives from 2,3-dihydroacridin-4(1H)-ones with 2-aminocarboxylic acid in presence phosphorus oxychloride at 130˚C yielded a novel class quin[1,2-b]acridine derivatives. The newly synthesized compounds showed better cytotoxic activity against HeLa and MCF-7 cell lines during the structure–activity relationship (SAR) studies. To discover interactions these molecules, we carried out molecular docking studies using...
The alarming increase in multidrug resistance, which includes Bedaquiline and Delamanid, stumbles success Tuberculosis treatment outcome. Mycobacterium tuberculosis gains resistance to rifampicin, is one of the less toxic potent anti-TB drugs, through genetic mutations predominantly besides efflux pump mediated drug resistance. In recent decades, scientific interventions are being carried out overcome this hurdle using novel approaches save by combining it with other drugs/molecules or use...
Abstract The novel and efficient synthetic route to the title compounds involves a decarboxylation reaction leading atanine (IV) followed either by Prevost′s affording furoquinolines (II) or cyclization with few drops of conc.
Background: The chemokine receptor CCR5 acts as a co-receptor for HIV binding and it is considered an important target by antagonists. Entry inhibitor based microbicides gain much importance nowadays these drugs act at early stage of lifecycle thus hinder the viral replication process in humans. present study intends to identify antagonist which could be developed microbicide using computational approaches. Keywords: antagonists, docking, 3D-QSAR, microbicides, molecular dynamics, pharmacophore.
Successive oxidative stress and biochemical changes results in neuronal death neuritic plaques growth Alzheimer's disease (AD).Therefore, it is interest to analyze amyloid-βeta precursor protein (APP), beta-secretase 1 (BACE1), presenilin (PSEN1 PSEN2) genes from brain tissues gain insights.Development of potential inhibitors for these targets significance.EST sequences 2898 539 786 (PSEN1) 314 (PSEN2) were analyzed this study.A contig with APP (contigs 1-4), BACE1 5-7), PSEN1 8, 9, 10, 11),...
Globally, the pharmaceutical industry is continuously driven in search of new anticancer drugs due to increasing rate cancer patients. Clinical trials Cisplatin has been explored, however, usage as a drug limited its various side effects, hence, alternative platinum based complex and analogues are needed. Iridium complexes have attracted widespread interests by virtue their pharmacological photo-physical properties; however less number was reported literature. In this article, series novel...