Introduction Lateral semicircular canal (LSCC) dysplasia is the most common inner ear malformation. The severity of can appear in various spectrums, from a short and broad LSCC with normal or small-sized central bony island (CBI) to single fluid-filled cavity confluent vestibule without CBI. However, reports on association between loss vestibular function are still lacking. In this study, results tests [caloric test video-head impulse (vHIT)] patients were analyzed compared groups Methods...

Cochlear implantation (CI) is a highly effective treatment for profound hearing loss in elderly individuals, including those with ARHL. However, factors influencing the success of CI population are not fully understood. Hence, we sought to investigate association regional cerebellar gray matter volume effectiveness elderly. This retrospective cross-sectional study included implantees and healthy controls aged ≥ 70 years. We used voxel-based morphometry associated speech perception outcome...

Abstract Objective Understanding the distinct subtypes of adhesive otitis media (AdOM) is crucial for appropriate treatment such as balloon Eustachian tuboplasty (BET), particularly in distinguishing between patulous and obstructive tube (ET) function. Nevertheless, AdOM caused by dysfunction (ETD) remains underexplored. This study aims to describe detailed characteristics define type associated with ETD (PET). Study Design A prospective cohort study. Setting total 62 ears patients diagnosed...

Cochlin is the most abundant protein in inner ear. The cleaved N-terminal domain of cochlin, known as LCCL and referred to CTP (cochlin tomoprotein) clinical biomarker usage, a perilymph-specific widely used detect perilymph leakage. However, little about secretion or presence middle ear, even though it can result false positives when using for We conducted translational research humans mice. A retrospective observational study was on human patients who underwent multiple tests after...

To investigate the pathophysiology of persistent geotropic direction-changing positional nystagmus (pGeo DCPN) by analyzing caloric responses and clinical course in patients with pGeo DCPN other variants lateral semicircular canal benign paroxysmal vertigo (LSCC BPPV). In this case-control prospective study, 101 diagnosed group, N=34), apogeotropic (pApo) (pApo N=40), or transient (tGeo) (tGeo N=27) involving LSCC were enrolled. The video head impulse test (vHIT) performed on day diagnosis....

It has been challenging to apply intravital imaging for monitoring the inner ear, as anatomical location and intricate structure hamper access of instruments ear live mice.By employing cochlea in mice with two-photon microscopy, we investigated neutrophil infiltration into tissue its characteristics under a lipopolysaccharide (LPS)-induced inflammatory state.Methods: Cochlea inflammation was induced by LPS injection middle ear.Using microscopy specifically designed surgical exteriorization...

Abstract Objectives/Hypothesis: To present the surgical technique and feasibility of robot‐assisted submandibular gland (SMG) resection via retroauricular approach. Study Design: Feasibility study case series. Methods: We performed SMG on five patients with benign tumors. The complications, operation time, amount bleeding, duration drainage, hospital stay were reviewed. Results: surgery was successful in all without any significant complications. mean time 62.4 ± 6.3 minutes, bleeding 10.4...

Background: The vestibular phenotypes of patients with genetic hearing loss are poorly understood. Methods: we performed testing including exome sequencing and function tests to investigate functions in loss. Results: Among 627 patients, 143 (22.8%) had symptoms. Genetic variations were confirmed 45 (31.5%) the patients. Nineteen deafness genes linked symptoms; most frequent autosomal dominant recessive individuals COCH SLC26A4, respectively. Vestibular symptoms mostly vertigo type,...

Cochlea macrophages regulate cochlea inflammation and may harbors the potentials to protect hearing function from injury, including acoustic overstimulation. macrophage numbers increase at 3-7 days after stimulation. However, exact timing of infiltration maturation inflammatory monocytes is unclear. Furthermore, neutrophils also be involved in this process. Therefore, study, we investigated time-dependent immune cell infiltration, transformation, neutrophil involvement following Flow...

Previous studies have reported that hearing loss (HL) is associated with dementia, although the mechanistic underpinnings remain elusive. This study aimed to evaluate changes in brain metabolism patients HL and different types of dementia.

This study investigated the synergistic effects of risk factors on age-related hearing loss (ARHL) using nationwide cross-sectional data 33,552 individuals from 2010‒2013 Korea National Health and Nutrition Examination Survey. Patients with ARHL were selected based their pure-tone audiometry results. Previously reported for analyzed logistic regression propensity score-matching, between score-matching. Of 12,570 aged 40-79 years, 2002 (15.9%) met criteria ARHL. Male sex, exposure to...

Neonatal hyperbilirubinemia is considered one of the most common causative factors hearing loss. Preterm infants are more vulnerable to neuronal damage caused by hyperbilirubinemia. This study aimed evaluate effect on threshold and auditory pathway in preterm serial brainstem response (ABR). In addition, we usefulness unconjugated bilirubin (UCB) level compared with total serum (TSB) bilirubin-induced loss.This was conducted 70 who failed universal newborn screening automated ABR. The...

Other SectionsABSTRACTINTRODUCTIONCOCHLIN: WHAT IS KNOWN?COCHLIN, THE DUAL-ARMED IMMUNE-REGULATOR OF INNER EARCONCLUSIONACKNOWLEDGEMENTSCONFLICTS INTERESTREFERENCES

Noise exposure leads to an increase in the macrophage population. This increment is thought be caused by transformation of infiltrated monocytes into macrophages rather than proliferation cochlear resident macrophages. However, studies on cochlea are scarce. Thus, we aimed investigate infiltration and their after noise exposure. In wild-type CX3CR1+/GFP C57/B6 mice, inflammatory were identified immunofluorescence mouse cells. The findings confirmed quantitated flow cytometry. One day...

Common cavity deformity is a rare congenital bony labyrinth malformation associated with profound hearing loss. Cochlear implants are widely used for rehabilitation common deformities; however, the reported prognosis poor. Due to deformed anatomical structure, it important consider position of electrodes maximize performance cochlear implant. The present study discusses impact electrode placement on outcomes.A retrospective medical chart review eight patients (10 implants) who received was...

Objectives. Resident macrophages are well known to be present in the cochlea, but exact patterns thereof spiral ligaments have not been discussed previous studies. We sought document distribution of intact cochleae using three-dimensional imaging.Methods. Cochleae were obtained from C-X3-C motif chemokine receptor 1<sup>+/GFP</sup> mice, and organ clearing was performed. Three-dimensional images cleared reconstructed two-photon microscopy. The locations individual investigated...

Abstract Introduction The modified nine‐step test is a classical method for evaluating Eustachian tube function. However, clinical interpretation of the increased maximal difference in middle ear pressure (mdMEP) unknown. We hypothesised that different reservoir effects mastoid cavity can bias results test. Methods A total 108 consecutive participants (216 ears) were retrospectively screened. Of these, 55 (82 who met inclusion/exclusion criteria enrolled. volumetric cavity, parameters...

Background: Endolymphatic sac tumor (ELST) is an extremely rare disease that does not have established clinical guidelines.Objective: To provide guidance for the diagnosis and management of ELSTs.Methods: We retrospectively reviewed medical records patients who were suspected to a lesion in location endolymphatic sac. Seven included. Histopathologic confirmed five ELSTs two other diseases.Results: All enrolled had hearing impairment. Facial palsy was found four out with ELST, whereas none...

Noise is one of the most common causes hearing loss in industrial countries. There are many studies about chemical agents to prevent noise-induced (NIHL). However, there no commercially available drug yet. Retinoic acid an active metabolite Vitamin A; it has anti-apoptic role NIHL. This study aims verify differences among selective agonists retinoic receptors (RARs) All-trans (ATRA), AM80 (selective receptor α agonist), AC261066 (Selective β1 and CD1530 λ agonist) were injected 6–7 weeks old...

Chemical labyrinthectomy using gentamicin is a popular method for treating intractable vertigo attacks in Meniere's disease. However, the risk of hearing loss remains major concern clinicians. We investigated effect simultaneous dexamethasone and application on preservation control patients with unilateral A single-institutional, prospective, single-blinded, randomized clinical trial was conducted. Gentamicin-soaked Gelfoam® directly applied oval window following middle ear exploration. On...

We investigated the clinical validity of and correlation between Eustachian Tube Dysfunction Questionnaire-7 (ETDQ-7) scores eustachian tube function test (ETFT) results in patients with a normal drum. The study included 49 (93 ears) unilateral or bilateral ear fullness over >3 months. All were administered ETDQ-7 survey underwent ETFT on same day. receiver operating characteristic (ROC) curve association statistically analyzed. not significantly correlated middle pressure. dysfunction (ETD)...