A5077427699- Occupational and environmental lung diseases
- Occupational exposure and asthma
- Air Quality and Health Impacts
- Occupational Health and Safety Research
- Pleural and Pulmonary Diseases
- Contact Dermatitis and Allergies
- Indoor Air Quality and Microbial Exposure
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Carcinogens and Genotoxicity Assessment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Smoking Behavior and Cessation
- Workplace Health and Well-being
- Influenza Virus Research Studies
- Head and Neck Cancer Studies
- Health, Medicine and Society
- Nutritional Studies and Diet
- Chemical Safety and Risk Management
- Pneumothorax, Barotrauma, Emphysema
- Sarcoidosis and Beryllium Toxicity Research
- Vaccine Coverage and Hesitancy
- Climate Change Communication and Perception
- Mass Spectrometry Techniques and Applications
- Neuroendocrine Tumor Research Advances
- Risk and Safety Analysis
- Telomeres, Telomerase, and Senescence
Hôpital Intercommunal de Créteil
2012-2024
Université Paris-Est Créteil
2004-2020
Inserm
2008-2020
Centre de recherche en Epidémiologie et Santé des Populations
2015-2020
Université Paris-Sud
2016-2020
Université de Versailles Saint-Quentin-en-Yvelines
2016-2020
Université Paris-Saclay
2016-2020
Faculty (United Kingdom)
2017
Assistance Publique – Hôpitaux de Paris
2017
Institut Gustave Roussy
2017
Telomere length is considered a marker for biological aging. Chronic obstructive pulmonary disease (COPD) may be associated with premature aging.To test the hypothesis that patients COPD experience accelerated telomere shortening and inflammation linked to this process.We measured length, using quantitative polymerase chain reaction-based method, plasma levels of various cytokines in 136 COPD, 113 age- sex-matched smokers, 42 nonsmokers normal lung function.Median (range) ratio was...
Abstract We describe a pertussis outbreak among adult patients in French general hospital following transmission from healthcare worker. This index case transmitted to other workers, who, turn, contaminated staff and two immuno-suppressed patients. raises questions about infection control.
Objectives: To assess the risk of lung cancer associated with occupations and industries. Methods: A French population-based case-control study included 2923 cases 3555 controls. Lifelong occupational history was collected. Two lists known (A) or suspected (B) to be were used. Occupations industries not in these also explored. Results: Among men, smoking-adjusted odds ratio 1.97 for list (attributable fraction: 12.3%), 1.4 B (due especially carpenters/joiners transport workers). unlisted...
<h3>Objectives</h3> We investigated the relationship between lung cancer and occupational exposure to welding activity in ICARE, a population-based case–control study. <h3>Methods</h3> Analyses were restricted men (2276 cases, 2780 controls). Welding was assessed through detailed questionnaires, including lifelong history. ORs computed using unconditional logistic regression, adjusted for cigarette smoking asbestos. <h3>Results</h3> Among regular welders, associated with risk of (OR=1.7, 95%...
Aims: To compare the prevalence and incidence of respiratory symptoms lung function values between hairdressing apprentices office apprentices. Methods: A total 322 277 (controls) were studied. Two cross sectional surveys conducted in 1994 1996/97 with longitudinal follow up for a subgroup (191 189 apprentices). Results: In initial phase, was significantly lower among than Lung test results showed higher Non-specific bronchial reactivity similar two groups. final similar. The not different...
<h3>Background</h3> The association between lung cancer and occupational exposure to organic solvents is discussed. Since different are often used <i>simultaneously</i>, it difficult assess the role of individual substances. <h3>Objectives</h3> present study focused on an in-depth investigation potential risk a large group solvents, taking into account well-known factors for cancer, tobacco smoking asbestos. <h3>Methods</h3> We analysed data from Investigation environmental causes...
Objectives: To assess the risk of lung cancer associated with exposure to mineral wools (MWs), while taking into account smoking, asbestos, and crystalline silica exposures. Methods: The analyses were restricted men (1350 cases 1912 controls). Lifelong occupational history was collected. MWs asbestos exposures assessed, using task-exposure matrices exposure, a job-exposure matrix. Results: We observed consistent not-significant increased risks same order magnitude among workers exposed high...
To investigate the role of occupational exposure to endotoxins in lung cancer a French population-based case-control study (ICARE (Investigation and environmental causes respiratory cancers)).Detailed information was collected on history smoking habits from 2926 patients with histologically confirmed 3555 matched controls. We evaluated each subject's endotoxin after cross referencing International Standard Classification Occupations (ISCO) codes (for job tasks) Nomenclature d'Activités...
<h3>Objective</h3> To investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology. <h3>Methods</h3> ICARE (Investigation and environmental CAuses REspiratory cancers) is a French, multicentre, population-based, case–control study. Information on lifelong work history 2926 cases 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed job-exposure matrices for five solvents. Solvents studied separately combinations....
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Lung cancer risk associated with occupational cleaning activities has been investigated in the population-based case-control study ICARE.Occupational history was collected by standardized interviews. Jobs were first defined according to International Standard Classification of Occupations (ISCO) codes and then categorized activity sectors. Adjusted odds ratios (ORs) estimated unconditional logistic regression, separately for women (619 cases 760 controls) men (2265 2780).Thirty percent 2.3%...
Abstract Background In the literature, criteria used to define pleural plaques (PP) and diffuse thickening (DPT) are very heterogeneous often imprecise. A multicenter restropective study was conducted assess relevance of two radiographic definitions DPT. Methods The population consisted 287 subjects with asbestos‐related thickening. Two were characterize DPT on postero‐anterior chest radiographs: definition 1: associated obliteration costophrenic angle; 2: at least 5 mm wide, extending for...
Objectives In a previous analysis of data from French population-based case–control study (the Investigation occupational and environmental CAuses REspiratory cancers (ICARE) study), ‘having ever worked’ in wood-related occupations was associated with excess lung cancer risk after adjusting for smoking but not factors. The present aimed to investigate the relationship between wood dust exposure exposures. Methods Data were obtained 2276 cases 2780 controls on habits lifelong history, using...
Background. In a French large population-based case-control study we investigated the dose-response relationship between lung cancer and occupational exposure to diesel motor exhaust (DME), taking into account asbestos exposure. Methods. Exposure DME was assessed by questionnaire. Asbestos taken through global indicator of carcinogens or specific JEM. Results. We found crude dose response with most indicators exposure, including cumulative index. All results were affected adjustment for The...
Abstract Background The number of cases pleural mesothelioma in France has varied substantially according to methods assessment. Materials and Methods We collected information from certifying physicians about 316 subjects who died between 1 July 1992 30 June 1993 three regions with a cause death coded as ICD‐9 category 163. ICD codes selected the for 178 deaths January 1987 31 December histologically confirmed diagnosed by an expert committee were examined. Finally, we used this estimate...
Background To investigate the association of lung cancer with occupational exposure to textile dust and specifically cotton in population‐based case‐control study ICARE. Methods Lifelong history 2926 cases 3555 controls was collected using standardized questionnaires, specific questions for exposure. Odds ratios (ORs) 95% confidence intervals (CI) were estimated unconditional logistic regression models controlling confounding factors including smoking asbestos Results An inverse between...
Leather dust is an established carcinogen of the sinonasal cavities; however, evidence lacking regarding its association with other head and neck cancers (HNC). To date, few studies have been conducted on between occupational leather exposure risk oral, pharyngeal, laryngeal cancers. The objective this study was to investigate HNC dust. Lifestyle habits history were collected for 2161 patients squamous cell carcinoma oral cavity, pharynx, larynx, 3555 controls, using a standardized...
Objective To investigate the association between occupational exposure to welding and risk of head neck cancer in a large French population-based case-control study, I nvestigation environmental CA uses RE spiratory cancers study. Methods Analyses were restricted men (2703 controls 1588 cases squamous-cell carcinoma oral cavity, oropharynx, hypopharynx larynx). Welding activity potential confounders assessed by detailed questionnaires. ORs CIs (95% CI) estimated unconditional logistic...
Abstract Since tumor growth factor beta (TGF- ) and its receptor are ubiquitously expressed because latent TGF- cannot bind to the cell surface receptor, ability of a activate upon secretion represents an important regulatory mechanism action. In vivo, protease plasm in is considered be one main enzymes operative proteolytic cleavage latency-associated peptide moiety from , which converts it into biologically active form. The response was characterized alveolar macrophages during pulmonary...
Although the neurological and cardiovascular effects of Freons have been extensively described, respiratory less well documented. We report four cases occupational asthma following accidental exposure to bromochlorodifluoromethane (Halon 1211) due release contents a fire extinguisher. All subjects developed an irritative reaction upper airways lower symptoms immediately after exposure. Non-specific bronchial hyperreactivity was present for at least two months in all still more than years one...
The hypothesis that asbestos exposure may have more specific associations with particular histological types of lung cancer remains controversial. aim this study was to analyze the relationships between and pulmonary carcinoid tumors. A retrospective case–control conducted in 28 cases undergoing surgery for tumors aged >40 years 56 controls a different type, matched gender age, from 1994 1999, recruited two hospitals region Paris. Asbestos assessed via expertise standardized occupational...